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Factors Associated With Menopause Symptoms: A Systematic Review and Meta-Analysis.

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Τίτλος: Factors Associated With Menopause Symptoms: A Systematic Review and Meta-Analysis.
Συγγραφείς: Hoang J; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.; Cancer Division, Leeds Institute of Clinical Trial Research, University of Leeds, Leeds, UK., Halliday K; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Allen D; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Mtika WM; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Tranter E; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Glover G; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Tatnell L; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Hippisley-Cox J; Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Coupland C; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.; Faculty of Medicine & Health Sciences, University of Nottingham, Nottingham, UK., Hillman S; Department of Applied Health, School of Health Sciences, University of Birmingham, Birmingham, UK., Hirst J; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Πηγή: BJOG : an international journal of obstetrics and gynaecology [BJOG] 2026 Oct; Vol. 133 (11), pp. 1967-1985. Date of Electronic Publication: 2026 May 06.
Τύπος έκδοσης: Journal Article; Systematic Review; Meta-Analysis
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 100935741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-0528 (Electronic) Linking ISSN: 14700328 NLM ISO Abbreviation: BJOG Subsets: MEDLINE
Imprint Name(s): Publication: : Oxford : Wiley-Blackwell
Original Publication: Oxford [England] : Blackwell Science, [2000]-
Ιατρικοί όροι (MeSH): Menopause*/physiology , Menopause*/ethnology , Hot Flashes*/etiology , Hot Flashes*/epidemiology, Vaginal Diseases/epidemiology ; Vasomotor System/physiopathology ; Humans ; Female ; Risk Factors ; Severity of Illness Index ; Middle Aged
Περίληψη: Background: Menopause, marked by hormonal decline and menstrual cessation, is associated with various symptoms. Socio-demographic and behavioural factors may influence symptom type and severity. Understanding these associations can inform better symptom management.
Objectives: To identify factors associated with the presence and severity of menopausal symptoms through systematic review and meta-analysis.
Search Strategy: We searched Medline, Embase, CINAHL and Cochrane for studies on demographic, behavioural, or health factors linked to vasomotor, vaginal dryness and joint symptoms in women aged 40-60.
Selection Criteria: Studies reporting odds ratios or raw numbers for symptom presence or severity were included.
Data Collection and Analysis: Studies were combined for meta-analysis, reporting odds ratios and 95% confidence intervals. Quality assessment was performed to quantify the risk of bias.
Results: Of 9228 screened articles, 61 were meta-analysed. Compared with White women, Black women had higher odds of vasomotor symptom presence (OR 1.65, 1.41-1.94) and severity (OR 1.91, 1.10-3.29), and vaginal dryness presence (OR 1.27, 1.10-1.47), while Asian had lower vasomotor symptom presence and severity (OR 0.40, 0.22-0.72; OR 0.55, 0.53-0.56). Higher education (OR 1.31, 1.09-1.56), high income (OR 1.41, 1.01-1.97) and depression (OR 2.36, 1.51-3.70) were associated with increased presence of vasomotor symptoms. Smoking and obesity were associated with both presence (OR 1.63, 1.30-2.04 and 1.35, 1.02-1.78) and severity (OR 1.56, 1.07-2.27 and 1.42, 1.11-1.83) of vasomotor symptoms.
Conclusion: Socio-demographic and behavioural factors, including ethnicity, education, income, smoking, obesity and depression, influence menopausal symptoms, highlighting the need for personalised care.
Trial Registration: PROSPERO number: CRD42023459154.
(© 2026 The Author(s). BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd.)
References: BMC Womens Health. 2024 Sep 4;24(1):487. (PMID: 39232712)
Menopause. 2024 Jun 1;31(6):476-483. (PMID: 38652870)
Maturitas. 2005 Nov-Dec;52(3-4):181-9. (PMID: 16257609)
J Womens Health (Larchmt). 2025 Jan;34(2):176-186. (PMID: 39589798)
Menopause. 2017 Jun;24(6):645-652. (PMID: 28118294)
Iran Red Crescent Med J. 2011 Mar;13(3):192-8. (PMID: 22737462)
Br J Gen Pract. 2025 Nov 27;75(761):e816-e823. (PMID: 40628417)
J Womens Health Gend Based Med. 2001 Jan-Feb;10(1):67-76. (PMID: 11224946)
Climacteric. 2023 Dec;26(6):537-549. (PMID: 37751852)
Cureus. 2022 Jun 20;14(6):e26122. (PMID: 35875302)
Menopause. 2005 May-Jun;12(3):258-66. (PMID: 15879914)
J Obstet Gynaecol Res. 2021 Oct;47(10):3677-3690. (PMID: 34278662)
Curr Diab Rep. 2023 Dec;23(12):361-370. (PMID: 37999882)
Ann Hum Biol. 2006 Jan-Feb;33(1):4-16. (PMID: 16500807)
Rev Bras Ginecol Obstet. 2022 Jun;44(6):586-592. (PMID: 35820423)
J Midlife Health. 2017 Jan-Mar;8(1):21-27. (PMID: 28458476)
Nutrients. 2022 May 29;14(11):. (PMID: 35684078)
Asian J Psychiatr. 2016 Oct;23:56-63. (PMID: 27969080)
J Transcult Nurs. 2010 Apr;21(2):123-33. (PMID: 20220032)
Am J Obstet Gynecol. 2003 Dec;189(6):1646-53. (PMID: 14710092)
Ann Hum Biol. 2019 Feb;46(1):46-55. (PMID: 30822155)
Maturitas. 2022 Feb;156:1-11. (PMID: 35033227)
Obstet Gynecol. 2003 Feb;101(2):264-72. (PMID: 12576249)
Womens Health (Lond). 2009 Mar;5(2):127-33. (PMID: 19245351)
J Pak Med Assoc. 2015 Apr;65(4):409-13. (PMID: 25976577)
Menopause. 2016 Jul;23(7):731-9. (PMID: 26926325)
Maturitas. 2004 Dec 10;49(4):292-303. (PMID: 15531125)
Ann Epidemiol. 2019 Sep;37:10-16. (PMID: 31447292)
Am J Med. 2006 Sep;119(9 Suppl 1):S52-60. (PMID: 16949389)
Gynecol Endocrinol. 2020 Nov;36(11):991-996. (PMID: 32573286)
Nutrition. 2018 Nov;55-56:161-167. (PMID: 30086485)
Health Care Women Int. 2009 Apr;30(4):339-55. (PMID: 19255887)
Menopause. 2024 Jun 1;31(6):484-493. (PMID: 38595299)
Menopause. 2009 Mar-Apr;16(2):286-92. (PMID: 19002015)
BMJ. 2012 Feb 08;344:e402. (PMID: 22318435)
Menopause. 2014 Aug;21(8):855-60. (PMID: 24398410)
BMC Womens Health. 2017 Dec 08;17(1):126. (PMID: 29216853)
BMJ Med. 2025 Sep 25;4(1):e001349. (PMID: 41035437)
J Coll Physicians Surg Pak. 2019 Sep;29(9):823-827. (PMID: 31455475)
JAMA. 2023 Oct 3;330(13):1278-1279. (PMID: 37713186)
Int J Cosmet Sci. 2012 Aug;34(4):332-7. (PMID: 22515333)
Womens Midlife Health. 2022 Feb 8;8(1):3. (PMID: 35130984)
Endocrinol Metab Clin North Am. 2015 Sep;44(3):497-515. (PMID: 26316239)
West J Nurs Res. 2010 Jun;32(4):540-65. (PMID: 20685910)
Am J Epidemiol. 2004 Jun 15;159(12):1189-99. (PMID: 15191936)
East Mediterr Health J. 2017 Oct 30;23(8):527-533. (PMID: 29105043)
Menopause. 2018 Nov;25(11):1331-1338. (PMID: 30358730)
Menopause. 2010 Jan-Feb;17(1):121-6. (PMID: 19574936)
Menopause. 2008 Sep-Oct;15(5):841-7. (PMID: 18521049)
Climacteric. 2006 Feb;9(1):13-22. (PMID: 16428121)
West J Nurs Res. 2019 Feb;41(2):217-237. (PMID: 29606085)
Menopause. 2020 Oct 05;28(2):126-134. (PMID: 33038144)
Sleep. 2021 Feb 12;44(2):. (PMID: 32918472)
Am J Obstet Gynecol. 2004 Dec;191(6):1979-88. (PMID: 15592280)
Menopause. 2014 Feb;21(2):182-7. (PMID: 23736861)
J Womens Health (Larchmt). 2010 May;19(5):975-85. (PMID: 20380577)
Maturitas. 2007 Jul 20;57(3):271-8. (PMID: 17329046)
Menopause. 2014 Feb;21(2):153-8. (PMID: 23760434)
J Midlife Health. 2021 Jul-Sep;12(3):199-205. (PMID: 34759701)
Med Care. 2003 Nov;41(11):1262-76. (PMID: 14583689)
JAMA Intern Med. 2015 Apr;175(4):531-9. (PMID: 25686030)
Am J Epidemiol. 2000 Sep 1;152(5):463-73. (PMID: 10981461)
Womens Health Rep (New Rochelle). 2021 Mar 16;2(1):44-52. (PMID: 33786530)
Reprod Sci. 2021 Sep;28(9):2661-2671. (PMID: 33751500)
Menopause. 2012 Sep;19(9):980-8. (PMID: 22781782)
Maturitas. 2013 Jun;75(2):152-8. (PMID: 23562010)
Climacteric. 2010 Aug;13(4):385-94. (PMID: 19731118)
Climacteric. 2018 Dec;21(6):586-593. (PMID: 30145921)
Medicina (Kaunas). 2019 Aug 11;55(8):. (PMID: 31405242)
Mayo Clin Proc. 2023 May;98(5):701-712. (PMID: 37137642)
Menopause. 2015 Oct;22(10):1098-107. (PMID: 25783472)
Menopause. 2016 Apr;23(4):433-40. (PMID: 26645818)
Menopause. 2007 Jan-Feb;14(1):150-6. (PMID: 17075431)
PLoS One. 2020 Mar 24;15(3):e0230515. (PMID: 32208445)
Climacteric. 2020 Feb;23(1):9-16. (PMID: 31533486)
BMJ. 2025 Sep 29;390:r2038. (PMID: 41022484)
Arch Intern Med. 2008 Apr 28;168(8):840-6. (PMID: 18443259)
J Public Health (Oxf). 2009 Jun;31(2):258-77. (PMID: 19208688)
Am J Obstet Gynecol. 2020 May;222(5):478.e1-478.e17. (PMID: 31705884)
Maturitas. 2013 Sep;76(1):64-9. (PMID: 23810489)
Asia Pac J Public Health. 2021 Jan;33(1):60-66. (PMID: 32975428)
J Midlife Health. 2020 Jul-Sep;11(3):137-143. (PMID: 33384536)
Maturitas. 1996 Aug;25(1):1-10. (PMID: 8887303)
Menopause. 2009 Jul-Aug;16(4):822-30. (PMID: 19242385)
Menopause. 2019 Oct;26(10):1178-1184. (PMID: 31408021)
BJOG. 2026 Jan 22;:. (PMID: 41572583)
Ann Intern Med. 2013 Feb 19;158(4):280-6. (PMID: 23420236)
J Womens Health. 1998 Nov;7(9):1149-55. (PMID: 9861592)
Menopause. 2016 Sep;23(9):942-9. (PMID: 27433864)
Maturitas. 2008 Dec 20;61(4):323-9. (PMID: 19010618)
Cad Saude Publica. 2005 Mar-Apr;21(2):469-81. (PMID: 15905909)
BMC Womens Health. 2023 May 25;23(1):287. (PMID: 37231489)
J Womens Health (Larchmt). 2007 Jan-Feb;16(1):124-33. (PMID: 17324103)
BMC Womens Health. 2021 May 7;21(1):192. (PMID: 33962601)
Maturitas. 2008 Feb 20;59(2):182-90. (PMID: 18234460)
Women Health. 2014;54(5):389-401. (PMID: 24791809)
Psychol Med. 2019 Jan;49(2):250-259. (PMID: 29622056)
Fertil Steril. 2014 Apr;101(4):1110-6. (PMID: 24491454)
Am Fam Physician. 2022 Apr 1;105(4):430-431. (PMID: 35426647)
Maturitas. 2020 Oct;140:41-48. (PMID: 32972634)
Menopause. 2014 Sep;21(9):924-32. (PMID: 24473530)
Int J Reprod Biomed. 2021 Oct 10;19(9):789-800. (PMID: 34723058)
Menopause. 2005 May-Jun;12(3):308-17. (PMID: 15879920)
J Sex Med. 2023 Feb 27;20(3):313-323. (PMID: 36763958)
Rural Remote Health. 2021 May;21(2):6457. (PMID: 33940925)
Menopause. 2009 Sep-Oct;16(5):870-6. (PMID: 19367185)
J Sex Med. 2017 May;14(5):675-686. (PMID: 28499520)
Am J Public Health. 2006 Jul;96(7):1226-35. (PMID: 16735636)
Climacteric. 2001 Dec;4(4):267-72. (PMID: 11770182)
Front Endocrinol (Lausanne). 2022 Apr 26;13:814872. (PMID: 35557846)
Grant Information: National Institute for Health and Care Research
Contributed Indexing: Keywords: disparities; menopause; meta‐analysis; symptoms; systematic review
Entry Date(s): Date Created: 20260506 Date Completed: 20260913 Latest Revision: 20260923
Update Code: 20260924
PubMed Central ID: PMC13571893
DOI: 10.1111/1471-0528.70257
PMID: 42087841
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1471-0528
DOI:10.1111/1471-0528.70257