Academic Journal
Transient receptor potential channels in Flaviviridae infection: A comprehensive review.
| Τίτλος: | Transient receptor potential channels in Flaviviridae infection: A comprehensive review. |
|---|---|
| Συγγραφείς: | Jiang F; School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, China., Yao X; School of Biomedical Sciences and Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China., Zheng CB; School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, China.; Yunnan Key Laboratory of Cross-Border Infectious Disease Control and Prevention and Novel Drug Development, China. |
| Πηγή: | Channels (Austin, Tex.) [Channels (Austin)] 2026 Dec; Vol. 20 (1), pp. 2665540. Date of Electronic Publication: 2026 May 05. |
| Τύπος έκδοσης: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101321614 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1933-6969 (Electronic) Linking ISSN: 19336950 NLM ISO Abbreviation: Channels (Austin) Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2015- : Philadelphia, PA : Taylor & Francis Original Publication: Austin, Tex. : Landes Bioscience, c2007- |
| Ιατρικοί όροι (MeSH): | Transient Receptor Potential Channels*/metabolism , Flaviviridae Infections*/metabolism , Flaviviridae Infections*/virology , Flaviviridae*/physiology , Flaviviridae*/metabolism, Humans ; Animals |
| Περίληψη: | Diseases caused by Flaviviridae viruses exert profound global health and economic burdens due to their high incidence and associated mortality. Infection by the Flaviviridae family often leads to severe acute or chronic illnesses, including hemorrhagic systemic diseases caused by dengue virus (DENV) and yellow fever virus, neurological complications associated with West Nile virus and Zika virus (ZIKV) infection, as well as liver damage and hepatocellular carcinoma resulting from hepatitis C virus (HCV) infection. Accumulating evidence indicates that a hallmark of Flaviviridae infection is to hijack calcium (Ca2+) signaling of the host cells, consequently facilitating viral entry, RNA replication, viral assembly, and release. Transient receptor potential (TRP) channels, a superfamily of nonselective cation channels, are central regulators of intracellular Ca2+ homeostasis. Recent studies reveal that TRP channels are closely involved in Flaviviridae infection. This comprehensive review synthesizes current findings on the role of TRP channels (e.g. TRPC, TRPV, TRPA, TRPM, and TRPML) in the pathogenesis of Flaviviridae viruses such as DENV, ZIKV, HCV, and Japanese encephalitis virus. Moreover, this review summarizes virus-TRP channel interaction mechanisms and discusses the potential of targeting TRP channels for host-directed antiviral therapies. This review aims to establish a conceptual framework for understanding TRP channel biology in Flaviviridae infection and to guide future research on antiviral strategies. Future directions should highlight the potential utility of TRP channel research for advancing anti-Flaviviridae therapies and clarifying their underlying mechanisms. |
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| Contributed Indexing: | Keywords: Flaviviridae; calcium signaling; transient receptor potential channels; viral infection |
| Substance Nomenclature: | 0 (Transient Receptor Potential Channels) |
| Entry Date(s): | Date Created: 20260505 Date Completed: 20260716 Latest Revision: 20260813 |
| Update Code: | 20260813 |
| PubMed Central ID: | PMC13154987 |
| DOI: | 10.1080/19336950.2026.2665540 |
| PMID: | 42084851 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1933-6969 |
|---|---|
| DOI: | 10.1080/19336950.2026.2665540 |