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Green-synthesized ZnO nanoparticles utilizing Garcinia mangostana leaves enhance performance, carcass traits, meat quality, antioxidant status, and insuline-like growth factor-1 gene expression in broiler chickens.

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Τίτλος: Green-synthesized ZnO nanoparticles utilizing Garcinia mangostana leaves enhance performance, carcass traits, meat quality, antioxidant status, and insuline-like growth factor-1 gene expression in broiler chickens.
Συγγραφείς: Rusli RK; Department of Nutrition and Feed Technology, Faculty of Animal Science, Universitas Andalas, Padang, 25175, Indonesia. ridhokurniawanrusli@ansci.unand.ac.id., Amizar R; Department of Nutrition and Feed Technology, Faculty of Animal Science, Universitas Andalas, Padang, 25175, Indonesia., Suci DM; Department of Animal Nutrition and Feed Technology, Faculty of Animal Science, IPB University, Bogor, 16680, Indonesia., Tanjung JT; Animal Science Bachelor Program, Faculty of Animal Science, Universitas Andalas, Padang, 25175, Indonesia., Nadia R; Department of Animal Nutrition and Feed Technology, Faculty of Animal Science, IPB University, Bogor, 16680, Indonesia., Hidayat C; Research Center for Animal Husbandry, The National Research and Innovation Agency, Jakarta, 10340, Indonesia., Zurmiati; Department of Nutrition and Feed Technology, Faculty of Animal Science, Universitas Andalas, Padang, 25175, Indonesia., Darmawan A; Department of Animal Nutrition and Feed Technology, Faculty of Animal Science, IPB University, Bogor, 16680, Indonesia., Reski S; Department of Nutrition and Feed Technology, Faculty of Animal Science, Universitas Andalas, Padang, 25175, Indonesia., Hilmi M; Study Program of Livestock Product Processing Technology, Politeknik Negeri Banyuwangi, Banyuwangi, 68461, Indonesia., Mahata ME; Department of Nutrition and Feed Technology, Faculty of Animal Science, Universitas Andalas, Padang, 25175, Indonesia., Gunawan A; Department of Animal Production and Technology, Faculty of Animal Science, IPB University, Bogor, 16680, Indonesia., Yuniza A; Department of Nutrition and Feed Technology, Faculty of Animal Science, Universitas Andalas, Padang, 25175, Indonesia., Mutia R; Department of Animal Nutrition and Feed Technology, Faculty of Animal Science, IPB University, Bogor, 16680, Indonesia.
Πηγή: Tropical animal health and production [Trop Anim Health Prod] 2026 May 05; Vol. 58 (4). Date of Electronic Publication: 2026 May 05.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Springer Country of Publication: United States NLM ID: 1277355 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-7438 (Electronic) Linking ISSN: 00494747 NLM ISO Abbreviation: Trop Anim Health Prod Subsets: MEDLINE
Imprint Name(s): Publication: 2005- : Heidelberg : Springer
Original Publication: Edinburgh, Livingstone.
Ιατρικοί όροι (MeSH): Zinc Oxide*/administration & dosage , Zinc Oxide*/metabolism , Zinc Oxide*/chemistry , Zinc Oxide*/pharmacology , Chickens*/growth & development , Chickens*/physiology , Chickens*/genetics , Antioxidants*/metabolism , Insulin-Like Growth Factor I*/genetics , Insulin-Like Growth Factor I*/metabolism , Meat*/analysis , Metal Nanoparticles*/administration & dosage, Animal Feed/analysis ; Dietary Supplements/analysis ; Diet/veterinary ; Plant Leaves/chemistry ; Nanoparticles/chemistry ; Gene Expression/drug effects ; Animals ; Male
Περίληψη: The study aimed to evaluate the impact of Zinc oxide nanoparticles (ZnO-NPs) on growth performance, carcass traits, meat color, antioxidant activity, and insuline-like growth factor-1 (IGF-1) gene expression in broiler chickens. This study used 200 Cobb500 broiler chicks aged two days. The observation was conducted for 5 weeks and used a completely randomized design with 4 treatments and 5 replications (10 chicks, each replicates). The treatment were: Control (basal diet); ZnO-NPs 50 (control + 50 mg Zn/kg); ZnO-NPs 75 (control + 75 mg Zn/kg); ZnO-NPs 100 (control + 100 mg Zn/kg). Performance, carcass traits, Zn content and antioxidant activity, meat color, and IGF-1 gene expression were observed. Supplementation of ZnO-NPs (d 1-14) significantly (P < 0.05) increased body weight and improved feed-to-gain ratio, whereas no effects (P > 0.05) were observed on average daily gain, average daily feed intake, or feed-to-gain ratio during days 15-35. Zinc oxide nanoparticles (ZnO-NPs) also significantly (P < 0.05) increased the hue (h*) value while reducing the lightness (L*) and redness (a*) of the breast. Supplementation enhanced Zn deposition and SOD enzyme activity, accompanied by a decrease in MDA concentration in the breast. However, ZnO-NPs did not affect (P > 0.05) carcass traits (percentage of breast, back, thigh, and drumstick meat), nor did the yellowness (b*) and chromaticity (c*) of breast meat and IGF-1 gene expression in the small intestine. Overall, the addition of ZnO-NPs at levels up to 100 mg Zn/kg in broiler chicken feed during the growth phase leads to optimal improvements in performance parameters. Mechanistically, ZnO-NPs function as redox modulators rather than direct antioxidants, eliciting dose-dependent pro-oxidant and antioxidant responses in broiler chickens. This modulatory effect contributes to enhanced antioxidant status, a tendency to support the IGF-1 gene expression profile, and a reduction in oxidative stress. Furthermore, breast meat derived from chickens supplemented with ZnO-NPs demonstrates potential as a functional food with added health benefits.
(© 2026. The Author(s), under exclusive licence to Springer Nature B.V.)
Competing Interests: Declarations. Ethical approval: All research procedures involving animals were carried out in accordance with ethical guidelines and regulations of the Ethics Committee of the Faculty of Medicine Universitas Andalas, with number 434/UN.16.2/KEP-FK/2025. Conflict of interest: The authors declare that they have no competing interests.
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Grant Information: 060/C3/DT.05.00/PL/2025 Fiscal Year 2025 Direktorat Jenderal Penguatan Riset dan Pengembangan
Contributed Indexing: Keywords: Antioxidant; Broiler; Insulin-like growth factor 1; Meat quality; Nanoparticles
Substance Nomenclature: SOI2LOH54Z (Zinc Oxide)
0 (Antioxidants)
67763-96-6 (Insulin-Like Growth Factor I)
Entry Date(s): Date Created: 20260505 Date Completed: 20260716 Latest Revision: 20260716
Update Code: 20260716
DOI: 10.1007/s11250-026-05055-0
PMID: 42084680
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1573-7438
DOI:10.1007/s11250-026-05055-0