Academic Journal
Risk factors of renal complications in childhood-onset non-surgical hypoparathyroidism: a long-term follow-up study.
| Τίτλος: | Risk factors of renal complications in childhood-onset non-surgical hypoparathyroidism: a long-term follow-up study. |
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| Συγγραφείς: | Chen Y; Key Laboratory of Endocrinology, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan Wangfujing, Beijing, 100730, China., Gao Y; Key Laboratory of Endocrinology, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan Wangfujing, Beijing, 100730, China., Wang J; Key Laboratory of Endocrinology, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan Wangfujing, Beijing, 100730, China., Song A; Key Laboratory of Endocrinology, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan Wangfujing, Beijing, 100730, China., Jiang Y; Key Laboratory of Endocrinology, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan Wangfujing, Beijing, 100730, China., Li M; Key Laboratory of Endocrinology, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan Wangfujing, Beijing, 100730, China., Xia W; Key Laboratory of Endocrinology, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan Wangfujing, Beijing, 100730, China., Xing X; Key Laboratory of Endocrinology, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan Wangfujing, Beijing, 100730, China. xingxp@pumch.cn., Wang O; Key Laboratory of Endocrinology, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan Wangfujing, Beijing, 100730, China. wang_ou2010@126.com. |
| Πηγή: | Endocrine [Endocrine] 2026 May 04; Vol. 91 (1). Date of Electronic Publication: 2026 May 04. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Humana Press Country of Publication: United States NLM ID: 9434444 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-0100 (Electronic) Linking ISSN: 1355008X NLM ISO Abbreviation: Endocrine Subsets: MEDLINE |
| Imprint Name(s): | Publication: Feb. 1996- : Totowa, NJ : Humana Press Original Publication: Houndsmills, Basingstoke, Hants, UK : Macmillan Press, c1994- |
| Ιατρικοί όροι (MeSH): | Hypoparathyroidism*/complications , Hypoparathyroidism*/epidemiology , Kidney Diseases*/epidemiology , Kidney Diseases*/etiology, Hypercalciuria/epidemiology ; Hypercalciuria/etiology ; Humans ; Female ; Risk Factors ; Male ; Retrospective Studies ; Follow-Up Studies ; Child ; Child, Preschool ; Adolescent ; Age of Onset ; Prevalence |
| Περίληψη: | CONTEXT: It is unclear about the prevalence and risk factors of renal complications in childhood-onset patients with non-surgical hypoparathyroidism (ns-HP), which significantly hinders the clinical management and prognosis improvement. OBJECTIVE: To investigate the prevalence and risk factors of chronic renal complications in childhood-onset ns-HP patients receiving conventional therapy. DESIGN AND SETTING: A retrospective cohort in childhood-onset patients with ns-HP at a tertiary care center, between 1977 and 2022. PATIENTS AND METHODS: Childhood-onset ns-HP patients who received conventional treatment and were followed for at least 1 year were enrolled. Kaplan-Meier survival analysis and Cox regression were performed to identify the risk factors of renal complications. Time-dependent ROC curves were utilized to explore their optimal cutoff values. RESULTS: A total of 143 patients were enrolled in our cohort. Excluding 6 cases with pre-existed RC, 29/137 (21.17%) cases developed renal calcification (RC) during follow-up of 11.5 ± 8.5 years. Compared with patients without RC, they had a higher proportion of hypercalciuria (52.69 ± 32.8% vs. 35.64 ± 25.84%, P = 0.015) and renal insufficiency (RI) (17.24% vs. 3.70%, P = 0.021). Serum calcium-phosphate product (Ca×PO4) (HR = 1.205, P = 0.033) and hypercalciuria proportion (HR = 1.048, P = 0.043) were independent risk factors for RC, with optimal cutoffs of 41.96 mg²/dL² (AUC = 0.735) and 60% (AUC = 0.697), respectively. RI occurred in 6.29% (9/143) of patients, and the highest serum TCa during treatment (HR = 7.277, P = 0.019) was the risk factor of RI. CONCLUSION: To reduce RC risk in childhood-onset ns-HP patients on conventional treatment, it is essential to consistently control the serum Ca×PO₄ and urinary calcium excretion. Hypercalcemia during the treatment should be avoided to prevent RI. |
| Competing Interests: | Declarations. Conflict of interests: The authors declare no competing interests. |
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| Grant Information: | No. 82070817 Ou Wang |
| Contributed Indexing: | Keywords: Non-surgical hypoparathyroidism; childhood-onset; renal calcification; renal insufficiency |
| Entry Date(s): | Date Created: 20260504 Date Completed: 20260627 Latest Revision: 20261010 |
| Update Code: | 20261010 |
| DOI: | 10.1007/s12020-026-04633-4 |
| PMID: | 42081067 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1559-0100 |
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| DOI: | 10.1007/s12020-026-04633-4 |