Academic Journal
Live birth rate after ART with donor semen in single women, lesbian couples and heterosexual couples: a systematic review and meta-analysis.
| Τίτλος: | Live birth rate after ART with donor semen in single women, lesbian couples and heterosexual couples: a systematic review and meta-analysis. |
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| Συγγραφείς: | Pont JC; Centre AMP NatiFiv - Groupe Inovie, Meaux, France., Begon E; Service de gynécologie et médecine de la reproduction, CHU Bordeaux, Hôpital Pellegrin, Bordeaux, France., Bouée S; Service de médecine et biologie de la reproduction, CHU Brest, Hôpital Morvan, Brest, France., Domin-Bernhard M; Département de gynécologie obstétrique et reproduction humaine, CHU de Rennes, Hôpital Sud, Rennes, France., Jaffré F; Clinique Mutualiste La Sagesse, Rennes, France., Languille S; Monitoring Force, Maisons-Laffitte, France., Simon V; Service de Médecine et Biologie de la Reproduction, Hôpital Jeanne de Flandre, CHU de Lille, Lille, France., Fréour T; Service de Médecine et Biologie de la Reproduction, Hôpital Mère et Enfant, CHU de Nantes, Nantes, France; Nantes Université, CHU Nantes, INSERM, Centre for Research in Transplantation and Translational Immunology, UMR 1064, Nantes, France; Association Nationale du Don D'Engendrement, Nancy, France. Electronic address: Thomas.freour@chu-nantes.fr. |
| Πηγή: | Reproductive biomedicine online [Reprod Biomed Online] 2026 Jul; Vol. 53 (1), pp. 105545. Date of Electronic Publication: 2026 Feb 06. |
| Τύπος έκδοσης: | Journal Article; Systematic Review; Meta-Analysis; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101122473 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1472-6491 (Electronic) Linking ISSN: 14726483 NLM ISO Abbreviation: Reprod Biomed Online Subsets: MEDLINE |
| Imprint Name(s): | Publication: <2009->: Amsterdam : Elsevier Original Publication: Cambridge, UK : Reproductive Healthcare Ltd. |
| Ιατρικοί όροι (MeSH): | Heterosexuality*/statistics & numerical data , Reproductive Techniques, Assisted*/statistics & numerical data , Live Birth*/epidemiology , Birth Rate* , Sexual and Gender Minorities* , Semen*, Humans ; Female ; Pregnancy ; Male ; Pregnancy Rate ; Fertilization in Vitro ; Insemination, Artificial, Heterologous |
| Περίληψη: | This systematic review and meta-analysis compared the live birth rate (LBR) after assisted reproductive technology (ART) with donor semen among single women, lesbian couples and heterosexual couples. Searches of PubMed, EMBASE and the Cochrane Library up to September 2025 identified seven eligible studies including 19,457 women. Separate analyses were performed for intrauterine insemination (IUI) and IVF. For IUI, single women had a significantly lower LBR than heterosexual couples [risk ratio (RR) = 0.70, 95% CI 0.66-0.74] and lesbian couples (RR = 0.67, 95% CI 0.63-0.72), whereas no significant difference was observed between heterosexual couples and lesbian couples. The clinical pregnancy rate was lower in single women compared with lesbian couples, but the pregnancy loss rate was similar across both groups. Sensitivity analyses confirmed these findings. Importantly, meta-regressions indicated that differences in LBR were no longer significant after adjusting for female age. Results from IVF studies were consistent with those from IUI analyses. Overall, single women using donor semen for ART showed lower success rates, largely explained by older maternal age. These findings highlight the importance of age adjustment, and provide evidence-based data for counselling individuals and couples considering ART with donor semen. (Copyright © 2026 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.) |
| Contributed Indexing: | Keywords: Donor semen; IUI; IVF; Lesbian couples; Live birth rate; Single women |
| Entry Date(s): | Date Created: 20260502 Date Completed: 20260711 Latest Revision: 20260711 |
| Update Code: | 20260712 |
| DOI: | 10.1016/j.rbmo.2026.105545 |
| PMID: | 42068970 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1472-6491 |
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| DOI: | 10.1016/j.rbmo.2026.105545 |