Academic Journal
Links between parental internalizing disorder severity and default mode network connectivity in adolescent offspring.
| Τίτλος: | Links between parental internalizing disorder severity and default mode network connectivity in adolescent offspring. |
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| Συγγραφείς: | Tan SL; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada; Mathison Centre for Mental Health Research and Education, University of Calgary, Calgary, AB, Canada. Electronic address: sulynn.tan@ucalgary.ca., Pawlak M; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada; Alberta Children Hospital Research Institute (ACHRI), University of Calgary, Calgary, AB, Canada; Mathison Centre for Mental Health Research and Education, University of Calgary, Calgary, AB, Canada., Bray S; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada; Alberta Children Hospital Research Institute (ACHRI), University of Calgary, Calgary, AB, Canada; Mathison Centre for Mental Health Research and Education, University of Calgary, Calgary, AB, Canada; Child and Adolescent Imaging Research (CAIR) Program, University of Calgary, Calgary, AB, Canada; Department of Radiology, University of Calgary, Calgary, AB, Canada; Department of Pediatrics, University of Calgary, Calgary, AB, Canada., Kopala-Sibley DC; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada; Alberta Children Hospital Research Institute (ACHRI), University of Calgary, Calgary, AB, Canada; Mathison Centre for Mental Health Research and Education, University of Calgary, Calgary, AB, Canada; Department of Psychiatry, University of Calgary, Calgary, AB, Canada. |
| Πηγή: | Journal of psychiatric research [J Psychiatr Res] 2026 Aug; Vol. 199, pp. 195-204. Date of Electronic Publication: 2026 Apr 29. |
| Τύπος έκδοσης: | Journal Article; Research Support, Non-U.S. Gov't |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Pergamon Press Country of Publication: England NLM ID: 0376331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1379 (Electronic) Linking ISSN: 00223956 NLM ISO Abbreviation: J Psychiatr Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Oxford : Pergamon Press |
| Ιατρικοί όροι (MeSH): | Child of Impaired Parents*/psychology , Default Mode Network*/diagnostic imaging , Default Mode Network*/physiopathology , Depression*/physiopathology , Depression*/diagnostic imaging , Anxiety*/physiopathology , Anxiety*/diagnostic imaging , Parents*/psychology, Humans ; Female ; Male ; Magnetic Resonance Imaging ; Adolescent ; Child ; Brain Mapping ; Severity of Illness Index ; Psychiatric Status Rating Scales |
| Περίληψη: | Background: Internalizing disorders have been linked to alterations in default mode network (DMN) resting-state functional connectivity (RSFC). Given the increased risk of internalizing disorders in offspring of parents with a history of internalizing disorders, this study examined associations between parental depression and anxiety severity and adolescent DMN RSFC. Methods: Participants were 116 parent-adolescent dyads with youth between ages of 11-17 years. Structured diagnostic interviews and self-report questionnaires were completed by parents and adolescents to assess history and severity of internalizing disorders. Adolescents completed resting-state functional magnetic resonance imaging to determine the RSFC between regions of the DMN including the medial prefrontal cortex (mPFC), posterior cingulate cortex (PCC), and bilateral lateral parietal cortices (LPC). Analyses examined region-of-interest (ROI) to ROI RSFC, with bivariate correlations and linear regressions used to assess whether child age, sex, child internalizing symptoms, and parental internalizing symptoms were associated with child RSFC alterations. Results: After controlling for child age, sex, internalizing symptoms, and in-scanner motion, increased parental depressive severity was associated with increased child RSFC between the PCC and right LPC. Child internalizing symptoms were also linked to decreased RSFC between the right LPC and the mPFC. Limitations: This study is limited by its modest sample size relative to effect sizes for functional connectivity-phenotype associations, cross-sectional design, and a relatively homogeneous sample in terms of ethnicity, socioeconomic status, and parental sex. Conclusions: Results suggest that, among youth with a parental history of depression or anxiety, increased severity of parental depression is associated with altered offspring DMN RSFC. (Copyright © 2026 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Adolescents; Anxiety; Default mode network; Depression; Familial risk; Resting-state functional connectivity |
| Entry Date(s): | Date Created: 20260502 Date Completed: 20260716 Latest Revision: 20260811 |
| Update Code: | 20260812 |
| DOI: | 10.1016/j.jpsychires.2026.04.038 |
| PMID: | 42068654 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1879-1379 |
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| DOI: | 10.1016/j.jpsychires.2026.04.038 |