Academic Journal
In silico modeling of transcatheter heart valve oversizing and ellipticity, Part I: Establishing credibility of an advanced model.
| Τίτλος: | In silico modeling of transcatheter heart valve oversizing and ellipticity, Part I: Establishing credibility of an advanced model. |
|---|---|
| Συγγραφείς: | Boxwell S; Mechanobiology and Medical Devices Research Group, Department of Biomedical Engineering, College of Science and Engineering, University of Galway, Galway, Ireland., Armfield D; School of Mechanical and Materials Engineering, University College Dublin, Dublin, Ireland; SFI I-Form Centre, University College Dublin, Dublin, Ireland., Cahalane RME; Mechanobiology and Medical Devices Research Group, Department of Biomedical Engineering, College of Science and Engineering, University of Galway, Galway, Ireland; Division of Cardiovascular Medicine, Department of Medicine, Centre for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston MA, USA., Hickey W; Structural Heart Division, Boston Scientific Corporation, Galway, Ireland., Cook S; Structural Heart Division, Boston Scientific Corporation, Galway, Ireland., Kelly P; Structural Heart Division, Boston Scientific Corporation, Galway, Ireland., Cardiff P; School of Mechanical and Materials Engineering, University College Dublin, Dublin, Ireland; SFI I-Form Centre, University College Dublin, Dublin, Ireland., McNamara LM; Mechanobiology and Medical Devices Research Group, Department of Biomedical Engineering, College of Science and Engineering, University of Galway, Galway, Ireland; CÚRAM, SFI Research Centre for Medical Devices, University of Galway, Galway, Ireland. Electronic address: laoise.mcnamara@universityofgalway.ie. |
| Πηγή: | Computer methods and programs in biomedicine [Comput Methods Programs Biomed] 2026 Aug 01; Vol. 282, pp. 109404. Date of Electronic Publication: 2026 Apr 24. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 8506513 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7565 (Electronic) Linking ISSN: 01692607 NLM ISO Abbreviation: Comput Methods Programs Biomed Subsets: MEDLINE |
| Imprint Name(s): | Publication: Limerick : Elsevier Scientific Publishers Original Publication: Amsterdam : Elsevier Science Publishers, c1984- |
| Ιατρικοί όροι (MeSH): | Computer Simulation* , Transcatheter Aortic Valve Replacement* , Heart Valve Prosthesis* , Models, Cardiovascular*, Humans ; Hemodynamics ; Stents ; Prosthesis Design ; Alloys ; Aortic Valve |
| Περίληψη: | Background and Objectives: Transcatheter aortic valve implantation (TAVI) is the most common modality of treatment for aortic stenosis. However, transcatheter heart valves (THVs) can be prone to early failure and an increase in thrombogenic events, yet the risk factors associated with these failure modes remain poorly understood. Computational modeling may be used to predict biomechanical and hemodynamic indices associated with degeneration and thrombogenicity, however existing models do not fully account for complex stent and leaflet material behavior, and establishing model credibility according to ASME VV-40 is required. Methods: In this study, we developed an advanced structural and hemodynamic in silico framework to predict the in vitro performance of a supra-annular, self-expanding THV across a range of clinically-relevant expansion and ellipticity indices. The THV was modelled by incorporating a novel 3-fiber material model for pericardium tissue leaflets and a super-elastic nitinol stent. Results: Calculation verification was conducted and, on this basis, we provide recommendations on mesh density, element integration and target time increment. Following verification, we validated our models with radial force, structural high-speed camera and hemodynamic particle image velocimetry testing across multiple THV deployment configurations. In the 'nominal sizing, circular' case, we predicted a similar geometric orifice area (4.35 vs 4.02 cm2), pinwheeling index (2.6% vs 2.7%), stent deflection (1.95 vs 1.76 mm) and flow velocity (1.33 vs 1.27 m/s) to in vitro data. Conclusion: We validated a novel structural and hemodynamic in silico framework for studying THVs, which will be applied to understand deployment factors contributing to structural degeneration and thrombogenicity. This framework also holds potential for guiding next-generation THV design and predictive procedural modeling. (Copyright © 2026 The Author(s). Published by Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: SB reports financial support was provided by Taighde Éireann – Research Ireland. DA reports a relationship with Boston Scientific Corporation that includes: funding grants. WH, SC and PK report a relationship with Boston Scientific Corporation that includes: employment. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Computational fluid dynamics; Finite element analysis; Transcatheter aortic valve implantation; Transcatheter heart valve; Validation; Verification |
| Substance Nomenclature: | 0 (Alloys) 2EWL73IJ7F (nitinol) |
| Entry Date(s): | Date Created: 20260501 Date Completed: 20260716 Latest Revision: 20260716 |
| Update Code: | 20260716 |
| DOI: | 10.1016/j.cmpb.2026.109404 |
| PMID: | 42066381 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1872-7565 |
|---|---|
| DOI: | 10.1016/j.cmpb.2026.109404 |