Academic Journal
A disrupted microbial network and an ecological shift towards anaerobes in NTM-infected cystic fibrosis patients.
| Τίτλος: | A disrupted microbial network and an ecological shift towards anaerobes in NTM-infected cystic fibrosis patients. |
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| Συγγραφείς: | Pailhoriès H; Univ Brest, INSERM, EFS, UMR 1078, GGB - Brest France., Velo-Suarez L; Univ Brest, INSERM, EFS, UMR 1078, GGB - Brest France; Brest Center for Microbiota Analysis (CBAM), Brest University Hospital - Brest France., Moalic Y; Brest Center for Microbiota Analysis (CBAM), Brest University Hospital - Brest France., Alcoforado-Diniz J; Univ Brest, INSERM, EFS, UMR 1078, GGB - Brest France., Gouriou S; Univ Brest, INSERM, EFS, UMR 1078, GGB - Brest France., Bessou A; French Cystic Fibrosis Registry, Vaincre la Mucoviscidose, Paris France., Cambau E; Université Paris Cité, IAME, Inserm UMR 1137, Service de mycobactériologie spécialisée et de référence, Laboratoire associé du CNR des mycobactéries et de la résistance des mycobactéries aux antituberculeux (CNR-MyRMA), AP-HP GHU Paris Nord, Hôpital Bichat, Paris, France., Burgel PR; Respiratory Medicine and National Cystic Fibrosis Reference Center, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris Cité, Institut Cochin, INSERM, CNRS, U1016 - Paris France., Herrmann JL; Univ Paris-Saclay, UVSQ, INSERM, Infection and Inflammation - Montigny-Le-Bretonneux France; AP-HP, Groupe Hospitalo-Universitaire Paris-Saclay, Hôpital Raymond Poincaré - Garches France., Héry-Arnaud G; Univ Brest, INSERM, EFS, UMR 1078, GGB - Brest France; Brest Center for Microbiota Analysis (CBAM), Brest University Hospital - Brest France; Department of Infectious Agents, Brest University Hospital - Brest France. Electronic address: hery@univ-brest.fr. |
| Συλλογικό Έργο: | CIMeNT Study Group |
| Πηγή: | Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society [J Cyst Fibros] 2026 Jul; Vol. 25 (4), pp. 655-663. Date of Electronic Publication: 2026 Apr 28. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101128966 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5010 (Electronic) Linking ISSN: 15691993 NLM ISO Abbreviation: J Cyst Fibros Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam ; New York : Elsevier, c2002- |
| Ιατρικοί όροι (MeSH): | Cystic Fibrosis*/microbiology , Cystic Fibrosis*/complications , Cystic Fibrosis*/physiopathology , Mycobacterium Infections, Nontuberculous*/microbiology , Mycobacterium Infections, Nontuberculous*/diagnosis , Bacteria, Anaerobic*/isolation & purification, Sputum/microbiology ; RNA, Ribosomal, 16S/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Humans ; Male ; Microbiota ; Female |
| Περίληψη: | Nontuberculous mycobacteria (NTM) are increasingly recognized as opportunistic pathogens in people with cystic fibrosis (pwCF), but the ecological factors shaping their presence remain poorly understood. This study characterized the airway microbiota associated with NTM-positive culture using 16S rRNA gene sequencing of sputum from 108 pwCF (36 NTM-positive and 72 NTM-negative), matched by age, sex at birth, and CFTR genotype. Analyses integrated diversity metrics, differential-abundance modeling, multivariate regression, and microbial network inference, while accounting for Pseudomonas aeruginosa colonization. NTM-positive individuals exhibited slightly higher α-diversity and enrichment in strictly anaerobic taxa such as Alloprevotella tannerae, Stomatobaculum spp., and Prevotella nanceiensis, alongside reduced network connectivity. P. aeruginosa remained the dominant ecological driver, strongly reducing community diversity and structure. Partial Least Squares regression revealed that CFTR modulators (lumacaftor/ivacaftor) use and lung function (FEV₁%) were associated with distinct, commensal-enriched communities. In contrast, NTM status was associated with a distinct axis, indicating an independent ecological niche. Overall, NTM-positive cultures were associated with an anaerobe-enriched but less structured microbiota, likely reflecting localized hypoxia and biofilm-associated microenvironments rather than a direct effect of disease severity or modulator therapy. These findings highlight the role of airway microecology in NTM presence and provide a framework for understanding host-microbe interactions in chronic CF airway infections. (Copyright © 2026 The Author(s). Published by Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare no conflict of interest regarding this article. |
| Contributed Indexing: | Keywords: Anaerobiosis / microbiology; Cystic Fibrosis / microbiology; Metagenomics / methods; Microbiota; Mycobacterium Infections, Nontuberculous / microbiology; Pseudomonas aeruginosa / physiology |
| Substance Nomenclature: | 0 (RNA, Ribosomal, 16S) 126880-72-6 (Cystic Fibrosis Transmembrane Conductance Regulator) |
| Entry Date(s): | Date Created: 20260428 Date Completed: 20260730 Latest Revision: 20260730 |
| Update Code: | 20260731 |
| DOI: | 10.1016/j.jcf.2026.04.005 |
| PMID: | 42049592 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1873-5010 |
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| DOI: | 10.1016/j.jcf.2026.04.005 |