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From laboratory to real-world exposure: correlating cosmetic patch test results with large-scale consumer safety data from e-commerce platforms.

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Τίτλος: From laboratory to real-world exposure: correlating cosmetic patch test results with large-scale consumer safety data from e-commerce platforms.
Συγγραφείς: Yang K; Shanghai Jiyan Biomedical Development Co., Ltd., Shanghai, China.; Yunnan Botanee Bio-technology Group Co., Ltd., Yunnan, China., Zhang Q; Shanghai Jiyan Biomedical Development Co., Ltd., Shanghai, China.; Yunnan Botanee Bio-technology Group Co., Ltd., Yunnan, China., Cheng D; Shanghai Jiyan Biomedical Development Co., Ltd., Shanghai, China.; Yunnan Botanee Bio-technology Group Co., Ltd., Yunnan, China., Wang F; Yunnan Botanee Bio-technology Group Co., Ltd., Yunnan, China.; Yunnan Yunke Characteristic Plant Extraction Laboratory Co., Ltd., Yunnan, China.
Πηγή: Frontiers in public health [Front Public Health] 2026 Apr 08; Vol. 14, pp. 1791667. Date of Electronic Publication: 2026 Apr 08 (Print Publication: 2026).
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Frontiers Editorial Office Country of Publication: Switzerland NLM ID: 101616579 Publication Model: eCollection Cited Medium: Internet ISSN: 2296-2565 (Electronic) Linking ISSN: 22962565 NLM ISO Abbreviation: Front Public Health Subsets: MEDLINE
Imprint Name(s): Original Publication: Lausanne : Frontiers Editorial Office
Ιατρικοί όροι (MeSH): Cosmetics*/adverse effects , Patch Tests* , Consumer Product Safety*, Humans
Περίληψη: Background: Limited research exists on revealing the correlation between laboratory safety tests and real-world safety feedback from consumers of cosmetics.
Objective: To establish cosmetovigilance by associating patch test results with consumer-reported adverse reaction (CRARs) feedback form e-commerce feedback for cosmetics targeting sensitive skin.
Methods: Patch tests were performed on a cohort of sensitive-skin cosmetics, and CRARs were extracted from e-commerce comments. A generalized linear model was utilized to analyze the association between patch test results and CRARs, considering functional claims and application modes.
Results: Among the patch test results of 64 cosmetics, 42 exhibited negative reactions, 21 showed doubtful reactions, and one cosmetic demonstrated a weak positive reaction. The model established with a warning threshold of two doubtful reactions proved to be optimal. Patch test results were associated with sensitization-related and pain-related CRARs, but not with acnegenic-related CRARs. Brightening and acne treatment cosmetics exhibited higher acnegenic and pain rates, while leave-on cosmetics had a higher sensitization rate.
Conclusion: The data-driven results show that cosmetics with 2 or more doubtful reactions in patch test have a significantly correlation with real-world CRARs, which reminds relevant practitioners to be more cautious about doubtful reactions in patch test.
(Copyright © 2026 Yang, Zhang, Cheng and Wang.)
Competing Interests: KY, QZ and DC were employed by Shanghai Jiyan Biomedical Development Co., Ltd. KY, QZ, DC and FW were employed by Yunnan Botanee Bio-technology Group Co., Ltd. FW was employed by Yunnan Yunke Characteristic Plant Extraction Laboratory Co., Ltd. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Contributed Indexing: Keywords: adverse reaction; cosmetics; cosmetovigilance; patch test; sensitive skin
Substance Nomenclature: 0 (Cosmetics)
Entry Date(s): Date Created: 20260424 Date Completed: 20260715 Latest Revision: 20260715
Update Code: 20260716
PubMed Central ID: PMC13100906
DOI: 10.3389/fpubh.2026.1791667
PMID: 42027913
Βάση Δεδομένων: MEDLINE
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  Data: From laboratory to real-world exposure: correlating cosmetic patch test results with large-scale consumer safety data from e-commerce platforms.
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  Data: <searchLink fieldCode="AU" term="%22Yang+K%22">Yang K</searchLink>; Shanghai Jiyan Biomedical Development Co., Ltd., Shanghai, China.; Yunnan Botanee Bio-technology Group Co., Ltd., Yunnan, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Q%22">Zhang Q</searchLink>; Shanghai Jiyan Biomedical Development Co., Ltd., Shanghai, China.; Yunnan Botanee Bio-technology Group Co., Ltd., Yunnan, China.<br /><searchLink fieldCode="AU" term="%22Cheng+D%22">Cheng D</searchLink>; Shanghai Jiyan Biomedical Development Co., Ltd., Shanghai, China.; Yunnan Botanee Bio-technology Group Co., Ltd., Yunnan, China.<br /><searchLink fieldCode="AU" term="%22Wang+F%22">Wang F</searchLink>; Yunnan Botanee Bio-technology Group Co., Ltd., Yunnan, China.; Yunnan Yunke Characteristic Plant Extraction Laboratory Co., Ltd., Yunnan, China.
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  Data: Background: Limited research exists on revealing the correlation between laboratory safety tests and real-world safety feedback from consumers of cosmetics.<br />Objective: To establish cosmetovigilance by associating patch test results with consumer-reported adverse reaction (CRARs) feedback form e-commerce feedback for cosmetics targeting sensitive skin.<br />Methods: Patch tests were performed on a cohort of sensitive-skin cosmetics, and CRARs were extracted from e-commerce comments. A generalized linear model was utilized to analyze the association between patch test results and CRARs, considering functional claims and application modes.<br />Results: Among the patch test results of 64 cosmetics, 42 exhibited negative reactions, 21 showed doubtful reactions, and one cosmetic demonstrated a weak positive reaction. The model established with a warning threshold of two doubtful reactions proved to be optimal. Patch test results were associated with sensitization-related and pain-related CRARs, but not with acnegenic-related CRARs. Brightening and acne treatment cosmetics exhibited higher acnegenic and pain rates, while leave-on cosmetics had a higher sensitization rate.<br />Conclusion: The data-driven results show that cosmetics with 2 or more doubtful reactions in patch test have a significantly correlation with real-world CRARs, which reminds relevant practitioners to be more cautious about doubtful reactions in patch test.<br /> (Copyright © 2026 Yang, Zhang, Cheng and Wang.)
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  Data: KY, QZ and DC were employed by Shanghai Jiyan Biomedical Development Co., Ltd. KY, QZ, DC and FW were employed by Yunnan Botanee Bio-technology Group Co., Ltd. FW was employed by Yunnan Yunke Characteristic Plant Extraction Laboratory Co., Ltd. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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