Academic Journal
From laboratory to real-world exposure: correlating cosmetic patch test results with large-scale consumer safety data from e-commerce platforms.
| Title: | From laboratory to real-world exposure: correlating cosmetic patch test results with large-scale consumer safety data from e-commerce platforms. |
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| Authors: | Yang K; Shanghai Jiyan Biomedical Development Co., Ltd., Shanghai, China.; Yunnan Botanee Bio-technology Group Co., Ltd., Yunnan, China., Zhang Q; Shanghai Jiyan Biomedical Development Co., Ltd., Shanghai, China.; Yunnan Botanee Bio-technology Group Co., Ltd., Yunnan, China., Cheng D; Shanghai Jiyan Biomedical Development Co., Ltd., Shanghai, China.; Yunnan Botanee Bio-technology Group Co., Ltd., Yunnan, China., Wang F; Yunnan Botanee Bio-technology Group Co., Ltd., Yunnan, China.; Yunnan Yunke Characteristic Plant Extraction Laboratory Co., Ltd., Yunnan, China. |
| Source: | Frontiers in public health [Front Public Health] 2026 Apr 08; Vol. 14, pp. 1791667. Date of Electronic Publication: 2026 Apr 08 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Frontiers Editorial Office Country of Publication: Switzerland NLM ID: 101616579 Publication Model: eCollection Cited Medium: Internet ISSN: 2296-2565 (Electronic) Linking ISSN: 22962565 NLM ISO Abbreviation: Front Public Health Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Lausanne : Frontiers Editorial Office |
| MeSH Terms: | Cosmetics*/adverse effects , Patch Tests* , Consumer Product Safety*, Humans |
| Abstract: | Background: Limited research exists on revealing the correlation between laboratory safety tests and real-world safety feedback from consumers of cosmetics. Objective: To establish cosmetovigilance by associating patch test results with consumer-reported adverse reaction (CRARs) feedback form e-commerce feedback for cosmetics targeting sensitive skin. Methods: Patch tests were performed on a cohort of sensitive-skin cosmetics, and CRARs were extracted from e-commerce comments. A generalized linear model was utilized to analyze the association between patch test results and CRARs, considering functional claims and application modes. Results: Among the patch test results of 64 cosmetics, 42 exhibited negative reactions, 21 showed doubtful reactions, and one cosmetic demonstrated a weak positive reaction. The model established with a warning threshold of two doubtful reactions proved to be optimal. Patch test results were associated with sensitization-related and pain-related CRARs, but not with acnegenic-related CRARs. Brightening and acne treatment cosmetics exhibited higher acnegenic and pain rates, while leave-on cosmetics had a higher sensitization rate. Conclusion: The data-driven results show that cosmetics with 2 or more doubtful reactions in patch test have a significantly correlation with real-world CRARs, which reminds relevant practitioners to be more cautious about doubtful reactions in patch test. (Copyright © 2026 Yang, Zhang, Cheng and Wang.) |
| Competing Interests: | KY, QZ and DC were employed by Shanghai Jiyan Biomedical Development Co., Ltd. KY, QZ, DC and FW were employed by Yunnan Botanee Bio-technology Group Co., Ltd. FW was employed by Yunnan Yunke Characteristic Plant Extraction Laboratory Co., Ltd. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. |
| Contributed Indexing: | Keywords: adverse reaction; cosmetics; cosmetovigilance; patch test; sensitive skin |
| Substance Nomenclature: | 0 (Cosmetics) |
| Entry Date(s): | Date Created: 20260424 Date Completed: 20260715 Latest Revision: 20260715 |
| Update Code: | 20260716 |
| PubMed Central ID: | PMC13100906 |
| DOI: | 10.3389/fpubh.2026.1791667 |
| PMID: | 42027913 |
| Database: | MEDLINE |
| ISSN: | 2296-2565 |
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| DOI: | 10.3389/fpubh.2026.1791667 |