Academic Journal
Quantifying 808 nm Laser Penetration in Live Mouse Brain: A Comparison of Photodiode and Fiber Probe Methods for Transcranial Photobiomodulation Dosimetry.
| Τίτλος: | Quantifying 808 nm Laser Penetration in Live Mouse Brain: A Comparison of Photodiode and Fiber Probe Methods for Transcranial Photobiomodulation Dosimetry. |
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| Συγγραφείς: | Wang Y; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China.; Department of Anesthesia Surgery, Xianyang Central Hospital of Shaanxi Province, Xianyang, China., Wang J; The Second Clinical Medical College of Shaanxi University of Traditional Chinese Medicine, Xianyang, China., Hu R; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China., Liu Y; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China., Mu L; Xi'an Lanji Medical Electronic Technology Co. Ltd., Xi'an, China., Xu X; Xijing Hospital, Fourth Military Medical University, Xi'an, China., He X; Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China., Liu J; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China. |
| Πηγή: | Lasers in surgery and medicine [Lasers Surg Med] 2026 Aug; Vol. 58 (6), pp. 499-508. Date of Electronic Publication: 2026 Apr 24. |
| Τύπος έκδοσης: | Journal Article; Comparative Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8007168 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-9101 (Electronic) Linking ISSN: 01968092 NLM ISO Abbreviation: Lasers Surg Med Subsets: MEDLINE |
| Imprint Name(s): | Publication: New York Ny : Wiley-Liss Original Publication: New York : Alan Liss |
| Ιατρικοί όροι (MeSH): | Low-Level Light Therapy*/methods , Low-Level Light Therapy*/instrumentation , Brain*/radiation effects , Fiber Optic Technology*/instrumentation , Radiometry*/instrumentation , Radiometry*/methods, Animals ; Mice ; Mice, Inbred C57BL ; Optical Fibers |
| Περίληψη: | Objective: Accurate dosimetry is critical for the safe and effective application of transcranial photobiomodulation (tPBM), particularly when targeting deep brain regions. This study quantitatively evaluates 808 nm light transmittance in mouse cranial tissue using direct photodiode detection and a fiber-optic probe coupled to a photodiode, and further assesses depth-resolved attenuation using a fiber-optic probe in the live mouse brain tissue. Methods: Detector-comparison experiments were conducted in freshly prepared mouse head specimens, and depth-resolved measurements were performed in vivo under physiologically preserved conditions using anesthetized C57BL/6 mice. Results: The photodiode detector collected an estimated 8.6-fold higher optical signal than the fiber optic probe under the present setup. This difference is attributed to the fiber's limited numerical aperture and reduced acceptance angle in tissue. Additional depth-resolved measurements revealed an exponential decline in transmittance, with significant attenuation observed in deep brain regions. Conclusions: These findings emphasize the need for calibration when using fiber-based detection and provide essential parameters for optimizing tPBM treatment protocols. This work contributes to improving transcranial PBM dose accuracy for mouse models. (© 2026 Wiley Periodicals LLC.) |
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| Grant Information: | [2022JM-572] Natural Science Basic Research Project of Science and Technology Department of Shaanxi Province |
| Contributed Indexing: | Keywords: 808 nm laser; fiber optic probe; photodiode detector; pulsed laser; transcranial photobiomodulation; transmittance |
| Entry Date(s): | Date Created: 20260424 Date Completed: 20260715 Latest Revision: 20260813 |
| Update Code: | 20260813 |
| PubMed Central ID: | PMC13371782 |
| DOI: | 10.1002/lsm.70140 |
| PMID: | 42027001 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1096-9101 |
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| DOI: | 10.1002/lsm.70140 |