[Observational and genetic epidemiological study on the association of alcohol consumption and chronic obstructive pulmonary disease in adults in 10 areas of China].

Bibliographic Details
Title:	[Observational and genetic epidemiological study on the association of alcohol consumption and chronic obstructive pulmonary disease in adults in 10 areas of China].
Authors:	Zeng ZQ; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China., Wen QR; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China., Sun DJY; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing 100191, China., Pei P; Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China., Guo Y; Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing 100037, China., Du HD; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, United Kingdom., Chen JS; China National Center for Food Safety Risk Assessment, Beijing 100022, China., Chen ZM; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, United Kingdom., Lyu J; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing 100191, China State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing 100191, China., Li LM; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing 100191, China., Yu CQ; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing 100191, China.
Source:	Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi [Zhonghua Liu Xing Bing Xue Za Zhi] 2026 Apr 10; Vol. 47 (4), pp. 595-602.
Publication Type:	Journal Article; Observational Study; English Abstract
Language:	Chinese
Journal Info:	Publisher: Zhonghua yi xue hui; Zhongguo yi xue ke xue yuan Liu xing bing xue wei sheng wu xue yan jiu suo Country of Publication: China NLM ID: 8208604 Publication Model: Print Cited Medium: Print ISSN: 0254-6450 (Print) Linking ISSN: 02546450 NLM ISO Abbreviation: Zhonghua Liu Xing Bing Xue Za Zhi Subsets: MEDLINE
Imprint Name(s):	Publication: Beijing : Zhonghua yi xue hui; Zhongguo yi xue ke xue yuan Liu xing bing xue wei sheng wu xue yan jiu suo Original Publication: [Beijing] : Zhonghua yi xue hui; Zhongguo yi xue ke xue yuan Liu xing bing xue wei sheng wu xue yan jiu suo, [1981-
MeSH Terms:	Pulmonary Disease, Chronic Obstructive/epidemiology , Pulmonary Disease, Chronic Obstructive/genetics , Alcohol Drinking*/epidemiology, China/epidemiology ; Alcohol Dehydrogenase/genetics ; Aldehyde Dehydrogenase/genetics ; Humans ; Male ; Middle Aged ; Female ; Genotype ; Aged ; Risk Factors ; Adult ; Aldehyde Dehydrogenase, Mitochondrial ; Surveys and Questionnaires
Abstract:	Objective: To investigate the associations between alcohol intake and risks of chronic obstructive pulmonary disease (COPD) using self-reported alcohol intake and genetically predicted mean alcohol intake in adults in 10 areas of China. Methods: This study used baseline data collected in 2004-2008 from the China Kadoorie Biobank, and the COPD outcome was determined through long-term follow-up. After excluding participants with cancer, coronary heart disease, stroke or transient ischemic attack, asthma, tuberculosis, or COPD at baseline, 445 523 participants were included in the observational analysis. A total of 133 168 participants with complete genotyping data were included in the genetic analysis, after the same exclusion criteria were applied. Alcohol consumption patterns were obtained through a baseline questionnaire. The mean alcohol intake of male non-abstainers was calculated based on the combination of ALDH2-rs671 and ADH1B-rs1229984 genotypes and the study region, and all participants were divided into six groups (C1-C6) accordingly. Cox proportional hazards regression models were used to estimate the associations between exposure factors and risk of incident COPD. Results: In the observational analysis, 11 825 incident cases of COPD were identified during an average follow-up period of (11.8±2.1) years. After adjusting for potential confounders, occasional and current drinking was associated with lower risk of incident COPD in males, with HRs (95%CIs) of 0.80 (0.74-0.86), 0.75 (0.68-0.83), 0.84 (0.76-0.93), 0.86 (0.76-0.97) and 0.84 (0.75-0.94) for occasional and current drinkers consuming pure alcohol <140.0, 140.0-, 280.0-, ≥420.0 g/week respectively, while there was no significant association between abstainers and risk of COPD. In females, compared with non-drinkers, the risk of COPD reduced in all groups except for current drinkers consuming pure alcohol 70.0-139.9 g/week, with HRs (95%CIs) of 0.81 (0.68-0.96), 0.87 (0.82-0.93), 0.78 (0.62-0.99) and 0.77 (0.62-0.96) for abstainers, occasional and current drinkers consuming pure alcohol <70.0, 70.0-, ≥140.0 g/week respectively. In the genetic analysis, the risk of COPD in the C2-C6 groups was similar to that of males in the C1 group. In females, only the C4 group had a lower COPD risk compared to the C1 group (HR=0.79, 95% CI: 0.63-0.99). Conclusion: The study does not support a causal association between alcohol consumption and the risk of COPD.
Grant Information:	2023ZD0510101, 2023ZD0510100 Noncommunicable Chronic Diseases-National Science and Technology Major Project; 82192901, 82192904, 82192900, 82388102 National Natural Science Foundation of China; 212946/Z/18/Z, 202922/Z/16/Z, 104085/Z/14/Z, 088158/Z/09/Z Wellcome Trust in the United Kingdom; Kadoorie Charitable Foundation in Hong Kong of China
Contributed Indexing:	Local Abstract: [Publisher, Chinese] 目的：评估中国10个地区成年人自报饮酒状况及基因预测的酒精摄入量与慢性阻塞性肺疾病（COPD）发病风险的关联。方法：利用中国慢性病前瞻性研究2004-2008年开展的基线调查数据，并通过长期随访确定COPD结局。观察性分析中剔除基线自报患有恶性肿瘤、冠心病、中风/小卒中发作、哮喘、肺结核或COPD的研究对象，最终纳入445 523例研究对象。在遗传分析中，采取相同的纳入排除标准，共纳入133 168例有完整基因分型数据的研究对象。饮酒信息通过基线问卷获取。按照ALDH2-rs671和ADH1B-rs1229984基因型组合及研究地区计算男性非戒酒者的平均纯酒精摄入量，并据此将所有研究对象分为6组（C1~C6）。采用Cox比例风险回归模型分析暴露因素与新发COPD结局风险间的关联。结果：观察性分析中，研究对象随访（11.8±2.1）年，共记录11 825例新发COPD事件。调整潜在的混杂因素后，男性中偶尔饮酒者及经常饮酒者COPD发病风险均有所降低，偶尔饮、经常饮<140.0、140.0~、280.0~和≥420.0 g/周的研究对象HR值（95%CI）分别为0.80（0.74~0.86）、0.75（0.68~0.83）、0.84（0.76~0.93）、0.86（0.76~0.97）和0.84（0.75~0.94），而戒酒与COPD发病风险无统计学关联；在女性中，与从不饮酒者相比，除经常饮酒70~ g/周与COPD发病风险无统计学关联外，其余各组发病风险均下降，已戒、偶尔饮、经常饮<70.0和≥140.0 g/周的研究对象HR值（95%CI）分别为0.81（0.68~0.96）、0.87（0.82~0.93）、0.78（0.62~0.99）和0.77（0.62~0.96）。遗传分析结果显示，与C1组研究对象相比，C2~C6组的男性COPD发病风险均无显著改变；在女性中，仅C4组COPD发病风险相较参照组有所降低（HR=0.79，95%CI：0.63~0.99）。结论：本研究结果不支持饮酒与COPD发病风险间的因果关联。.
Substance Nomenclature:	EC 1.1.1.1 (Alcohol Dehydrogenase) EC 1.2.1.3 (ALDH2 protein, human) EC 1.2.1.3 (Aldehyde Dehydrogenase, Mitochondrial) EC 1.1.1.1 (ADH1B protein, human) EC 1.2.1.3 (Aldehyde Dehydrogenase)
Entry Date(s):	Date Created: 20260422 Date Completed: 20260715 Latest Revision: 20260715
Update Code:	20260716
DOI:	10.3760/cma.j.cn112338-20251029-00770
PMID:	42020159
Database:	MEDLINE

Description
ISSN:	0254-6450
DOI:	10.3760/cma.j.cn112338-20251029-00770