Academic Journal
Prostaglandin E2 stimulates GLP-1 and GLP-2 secretion and reduces glucose absorption in the perfused rat small intestine.
| Τίτλος: | Prostaglandin E2 stimulates GLP-1 and GLP-2 secretion and reduces glucose absorption in the perfused rat small intestine. |
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| Συγγραφείς: | Friis J; Department of Biomedical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.; Department of Endocrinology, Hvidovre Hospital, Copenhagen University Hospital, Hvidovre DK-2650, Denmark., Modvig IM; Department of Biomedical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark., Cookson TA; Department of Biomedical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark., Abba V; Department of Biomedical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark., Juhl CB; Department of Diabetes, Endocrinology and Obesity, Esbjerg and Grindsted Hospital, University Hospital of Southern Denmark, Esbjerg DK-6700, Denmark., Hartmann B; Department of Biomedical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark., Holst JJ; Department of Biomedical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark., Veedfald S; Department of Biomedical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.; Department of Digestive Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen DK-2100, Denmark. |
| Πηγή: | Endocrinology [Endocrinology] 2026 Jul 08; Vol. 167 (8). |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375040 Publication Model: Print Cited Medium: Internet ISSN: 1945-7170 (Electronic) Linking ISSN: 00137227 NLM ISO Abbreviation: Endocrinology Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2017- : New York : Oxford University Press Original Publication: Los Angeles, Calif. : Association for the Study of Internal Secretions |
| Ιατρικοί όροι (MeSH): | Dinoprostone*/pharmacology , Glucagon-Like Peptide 2*/metabolism , Glucose*/metabolism , Glucagon-Like Peptide 1*/metabolism , Intestine, Small*/metabolism , Intestine, Small*/drug effects , Intestinal Absorption*/drug effects, Indomethacin/pharmacology ; Animals ; Male ; Rats ; Perfusion ; Rats, Wistar |
| Περίληψη: | Prostaglandins (PGs) are paracrine mediators derived from arachidonic acid. In the gut, they regulate mucosal integrity, epithelial function, and inflammation. Glucose and possibly also prostaglandin E2 (PGE2) stimulate the release of glucagon-like peptide 1 (GLP-1). As PGE2 has been reported to modulate intestinal glucose absorption, the aim of this study was to investigate the acute effect of PGE2 on GLP-1 and GLP-2 secretion as well as intestinal glucose absorption using a physiologically relevant experimental setup-the isolated perfused rat small intestine. Two protocols were employed: A, luminal glucose instillation before and during an intra-arterial infusion of PGE2 (10 µmol/L); and B, same as protocol A, but with the COX inhibitor indomethacin (10 µmol/L) included in the perfusion buffer to block endogenous PG production. Administration of PGE2 stimulated the release of GLP-1 (2.1-fold; P = .002) and GLP-2 (2.5-fold; P = .002) from the perfused intestine vs vehicle. Inclusion of indomethacin in the perfusion buffer neither affected GLP-1 and GLP-2 secretion nor responses to PGE2, consistent with minimal production of PGs in the noninflamed in situ-perfused intestine. We observed a decrease in glucose absorption during administration of PGE2 vs vehicle (P = .043). PGE2 stimulates the secretion of GLP-1 and GLP-2, adding to its established roles in intestinal physiology. Acute administration of PGE2 significantly attenuated small intestinal glucose absorption. Our data confirm that PGE2 stimulates gut hormone release, which could be responsible for some of the effects ascribed to PGE2 and might explain the adverse effects associated with the inhibition of PG synthesis with nonsteroidal anti-inflammatory drugs. (© The Author(s) 2026. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com. See the journal About page for additional terms.) |
| Grant Information: | 0072088 Novo Nordisk Foundation; 10.46540/3101-00127B Danmarks Frie Forskningsfond |
| Contributed Indexing: | Keywords: glucagon-like pepetide-2 (GLP-2); glucagon-like peptide-1 (GLP-1); glucose; hormone secretion; intestinal perfusion; prostaglandin E2 |
| Substance Nomenclature: | K7Q1JQR04M (Dinoprostone) 0 (Glucagon-Like Peptide 2) IY9XDZ35W2 (Glucose) 89750-14-1 (Glucagon-Like Peptide 1) XXE1CET956 (Indomethacin) |
| Entry Date(s): | Date Created: 20260421 Date Completed: 20260716 Latest Revision: 20260716 |
| Update Code: | 20260717 |
| DOI: | 10.1210/endocr/bqag033 |
| PMID: | 42011909 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1945-7170 |
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| DOI: | 10.1210/endocr/bqag033 |