Academic Journal
Efficacy of red light for myopia control from age 2 to 24 with diverse treatment periods: A real-world study.
| Τίτλος: | Efficacy of red light for myopia control from age 2 to 24 with diverse treatment periods: A real-world study. |
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| Συγγραφείς: | Chen Y; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China; School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China; Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Hong Kong, China., Wu Y; School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China., Wang L; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China., Zhu Z; Centre for Eye Research Australia, Ophthalmology, University of Melbourne, Melbourne, VIC, Australia., Shang X; School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China; Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Hong Kong, China., Li J; Centre for Eye and Vision Research (CEVR), 17 W Hong Kong Science Park, Hong Kong, China., Ni Y; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China., Chen Y; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China., Jiang F; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China., Xiong R; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China., Yang X; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China., He M; School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China; Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Hong Kong, China; Centre for Eye and Vision Research (CEVR), 17 W Hong Kong Science Park, Hong Kong, China. Electronic address: mingguang.he@polyu.edu.hk., Zeng J; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China. Electronic address: zeng_zoc@163.com. |
| Πηγή: | Photodiagnosis and photodynamic therapy [Photodiagnosis Photodyn Ther] 2026 Jun; Vol. 59, pp. 105481. Date of Electronic Publication: 2026 Apr 18. |
| Τύπος έκδοσης: | Journal Article; Multicenter Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101226123 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1597 (Electronic) Linking ISSN: 15721000 NLM ISO Abbreviation: Photodiagnosis Photodyn Ther Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam ; Boston : Elsevier, c2004- |
| Ιατρικοί όροι (MeSH): | Myopia*/therapy , Myopia*/drug therapy , Myopia*/radiotherapy , Low-Level Light Therapy*/methods , Low-Level Light Therapy*/adverse effects , Red Light*, Humans ; Prospective Studies ; Child ; Child, Preschool ; Adolescent ; Male ; Female ; Visual Acuity ; Treatment Outcome ; China ; Refraction, Ocular ; Axial Length, Eye |
| Περίληψη: | Purpose: To explore the age-specific efficacy, long-term outcomes and safety of RLRL therapy in real-world clinical settings. Methods: In the prospective, multi-center, real-world cohort, 2825 participants who underwent low-level red light (RLRL) therapy for myopia control were recruited from 20 hospitals in China. Axial length (AL), spherical equivalent refraction (SER), best-corrected visual acuity (BCVA), compliance, and adverse events were recorded at baseline and each visit. Follow-up duration was stratified into four periods (≤ 6, 7-12, 13-24, and 25-36 months). Efficacy was estimated as the annual changes of AL using longitudinal linear mixed-effect model. Results: AL increased slightly in children aged 2-7 and 8-12 years, but remained stable in those aged 13-24 years. During the first 6 months, annual axial length (AL) changes reached -0.18, -0.29, and -0.72 mm for the 2-7, 8-12, and 13-24 group, and shifted to 0.14, 0.06, and -0.01 mm with 25-36 months of treatment. Multivariable analyses identified larger baseline AL (β = 0.72, p < 0.001) and the oldest age group (β = 0.82, p = 0.009) as independent predictors of AL shortening, while combining orthokeratology offered no additional benefit (p > 0.05). Adverse events were infrequent (0.21%). Conclusions: RLRL therapy is an effective and well-tolerated approach for myopia control across a broad age range and up to 36 months, showing sustained efficacy and favorable safety in real-world clinical settings. (Copyright © 2026 The Author(s). Published by Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The author(s) have made the following disclosure(s): Z.Z.: Patent of red light therapy titled “Method for increasing blood flow and metabolic rate of eye fundus” (US11420072; CN201910490186.6; AU2020233703C1). Z.Z.: Clinical Director of Eyerising International Pty Ltd. M.H.: Patent of red light therapy titled “Method for increasing blood flow and metabolic rate of eye fundus” (US11420072; CN201910490186.6; AU2020233703C1). He is also the director and shareholder of Eyerising International Pty Ltd. |
| Contributed Indexing: | Keywords: Axial length; Myopia progression; Real world study; Red light |
| Entry Date(s): | Date Created: 20260420 Date Completed: 20260613 Latest Revision: 20260615 |
| Update Code: | 20260616 |
| DOI: | 10.1016/j.pdpdt.2026.105481 |
| PMID: | 42009154 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1873-1597 |
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| DOI: | 10.1016/j.pdpdt.2026.105481 |