Academic Journal
Diarylheptanoid derivatives with α-synuclein aggregation inhibitory activities from the rhizome of Alpinia officinarum.
| Τίτλος: | Diarylheptanoid derivatives with α-synuclein aggregation inhibitory activities from the rhizome of Alpinia officinarum. |
|---|---|
| Συγγραφείς: | Li XY; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, PR China; Guangdong-Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China., She JF; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, PR China; Guangdong-Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China., Lv QM; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, PR China; Guangdong-Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China., Min L; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, PR China; Guangdong-Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China., Zhang SQ; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, PR China; Guangdong-Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China., Shi L; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, PR China; Guangdong-Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China., Huang XJ; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, PR China; Guangdong-Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China., Wang Y; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, PR China; Guangdong-Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China., Wang L; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, PR China; Guangdong-Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China., Song JG; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, PR China; Guangdong-Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China. Electronic address: songjianguof403@126.com., Che CT; Department of Pharmaceutical Science, Retzky College of Pharmacy, University of Illinois Chicago, Chicago, IL 60612, United States., Ye WC; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, PR China; Guangdong-Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China. Electronic address: chywc@aliyun.com., Wu ZL; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, PR China; Guangdong-Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China. Electronic address: wuzhenlong@hotmail.com. |
| Πηγή: | Fitoterapia [Fitoterapia] 2026 Jun; Vol. 191, pp. 107250. Date of Electronic Publication: 2026 Apr 16. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia Subsets: MEDLINE |
| Imprint Name(s): | Publication: 1999- : [Amsterdam] : Elsevier Original Publication: Milano : Inverni & Della Beffa S.p.A. |
| Ιατρικοί όροι (MeSH): | Alpinia*/chemistry , Diarylheptanoids*/pharmacology , Diarylheptanoids*/chemistry , Diarylheptanoids*/isolation & purification , alpha-Synuclein*/metabolism , alpha-Synuclein*/antagonists & inhibitors , Rhizome*/chemistry , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/chemistry , Neuroprotective Agents*/isolation & purification , Plant Extracts*/pharmacology , Plant Extracts*/chemistry, Protein Aggregates/drug effects ; Humans ; Cell Line, Tumor ; Circular Dichroism |
| Περίληψη: | Seven undescribed diarylheptanoid derivatives, alpinins A - G (1-7), together with nine known ones (8-16), were isolated and identified from the rhizomes of Alpinia officinarum Hance. Architecturally, compounds 1-4 represent four unusual dimeric diarylheptanoids featuring distinct linkage patterns, while compounds 5 and 6 are newly identified adducts consisting of diarylheptanoid motifs with a sesquiterpene and a monoterpene unit, respectively. The structures and absolute configurations of these compounds were elucidated by comprehensive spectroscopic data, DFT-based DP4+ analysis, as well as electronic circular dichroism (ECD) calculations. Additionally, the α-synuclein aggregation inhibitory activities of these isolates were evaluated using native mass spectrometry and fluorescence-based assays. Among them, compounds 7, 10, 12, and 13 exhibited significant inhibitory effects on α-synuclein aggregation and showed potent neuroprotective activities against α-synuclein aggregate-induced cytotoxicity in SH-SY5Y cells. (Copyright © 2026 Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare no conflict of interest. |
| Contributed Indexing: | Keywords: Alpinia officinarum; Diarylheptanoid derivatives; Native mass spectrometry; Neuroprotective activity; Α-Synuclein aggregation |
| Substance Nomenclature: | 0 (Diarylheptanoids) 0 (alpha-Synuclein) 0 (Neuroprotective Agents) 0 (Protein Aggregates) 0 (Plant Extracts) |
| Entry Date(s): | Date Created: 20260418 Date Completed: 20260715 Latest Revision: 20260715 |
| Update Code: | 20260715 |
| DOI: | 10.1016/j.fitote.2026.107250 |
| PMID: | 42000082 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1873-6971 |
|---|---|
| DOI: | 10.1016/j.fitote.2026.107250 |