Academic Journal
Dual role of spreading depolarization in an epileptic focus.
| Τίτλος: | Dual role of spreading depolarization in an epileptic focus. |
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| Συγγραφείς: | Vinokurova D; Laboratory of Neurobiology, Kazan Federal University, Kazan, Russia., Tukhvatullina K; Laboratory of Neurobiology, Kazan Federal University, Kazan, Russia., Khazipov R; Laboratory of Neurobiology, Kazan Federal University, Kazan, Russia.; Aix-Marseille University, L'Institut de Neurobiologie de la Méditerranée (INMED), Institut national de la santé et de la recherche médicale (Inserm), Marseille, France., Nasretdinov A; Laboratory of Neurobiology, Kazan Federal University, Kazan, Russia. |
| Πηγή: | Epilepsia [Epilepsia] 2026 Jul; Vol. 67 (7), pp. 3815-3828. Date of Electronic Publication: 2026 Apr 15. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Blackwell Science Country of Publication: United States NLM ID: 2983306R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1167 (Electronic) Linking ISSN: 00139580 NLM ISO Abbreviation: Epilepsia Subsets: MEDLINE |
| Imprint Name(s): | Publication: Malden, MA : Blackwell Science Original Publication: Copenhagen : Munskgaard |
| Ιατρικοί όροι (MeSH): | Cortical Spreading Depression*/physiology , Epilepsy*/physiopathology , Parietal Lobe*/physiopathology , Parietal Lobe*/drug effects, Seizures/physiopathology ; Potassium Channel Blockers/pharmacology ; Animals ; Electrocorticography ; Rats ; Male ; Rats, Sprague-Dawley ; 4-Aminopyridine |
| Περίληψη: | Objective: Spreading depolarizations (SDs) are often associated with epileptic discharges. Although SDs are traditionally thought to contribute to postictal depression and termination of epileptic discharges, seizures may also occur during SDs or may even follow SDs, suggesting that interactions between SD and seizures are more complex. Here, we examined the interactions between SD and epileptic activity by spatially separating the epileptic focus and the site of SD initiation. Methods: Subdural electrocorticographic arrays (6 × 10 electrodes) and intracortical silicon probes were used to record SDs and epileptic activity in the rat parietal cortex. An epileptic focus was induced by local intracortical injection of the potassium channel blocker 4-aminopyridine combined with the γ-aminobutyric acid type A receptor antagonist gabazine, whereas extrinsic SDs were evoked by distal high-potassium solution application. Results: We found that extrinsic SDs exerted a biphasic effect; they initially promoted seizurelike events (SLEs) when the SD wave approached the epileptic focus, which was then followed by suppression of epileptic activity after the SD spread through the focus. The timing of SLEs relative to SDs varied at different recording sites, with SLEs occurring before, during, or after SD arrival depending on electrode position along the trajectory of SD propagation between the SD initiation site and the epileptic focus. During intracortical recordings, the proconvulsive effects of SD were associated with a wave of pre-SD neuronal excitation reaching the epileptic focus. The epileptic focus per se also demonstrated resistance to the SD invasion. Significance: The interactions between SDs and an epileptic focus are not limited to postictal depression, and SDs may also promote epileptic activity in the hyperexcitable cortex. (© 2026 The Author(s). Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.) |
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| Grant Information: | 22-15-00236-P Russian Science Foundation |
| Contributed Indexing: | Keywords: EEG; electrocorticography; epilepsy; postictal depression; seizure initiation; spreading depolarization |
| Substance Nomenclature: | BH3B64OKL9 (4-Aminopyridine) 0 (Potassium Channel Blockers) |
| Entry Date(s): | Date Created: 20260415 Date Completed: 20260713 Latest Revision: 20260813 |
| Update Code: | 20260813 |
| PubMed Central ID: | PMC13360997 |
| DOI: | 10.1002/epi.70252 |
| PMID: | 41984509 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1528-1167 |
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| DOI: | 10.1002/epi.70252 |