Academic Journal
Mitigation of antibiotics and antibiotic resistance genes in livestock manure anaerobic digestion: a quantitative review and integrated control framework.
| Title: | Mitigation of antibiotics and antibiotic resistance genes in livestock manure anaerobic digestion: a quantitative review and integrated control framework. |
|---|---|
| Authors: | Wei B; College of Animal Science and Technology, Chongqing Key Laboratory of Herbivore Science, Southwest University, Chongqing, China., Zhang X; College of Animal Science and Technology, Chongqing Key Laboratory of Herbivore Science, Southwest University, Chongqing, China., Zhang X; College of Animal Science and Technology, Chongqing Key Laboratory of Herbivore Science, Southwest University, Chongqing, China., Shu L; College of Animal Science and Technology, Chongqing Key Laboratory of Herbivore Science, Southwest University, Chongqing, China., Han S; College of Animal Science and Technology, Chongqing Key Laboratory of Herbivore Science, Southwest University, Chongqing, China., Zhao A; College of Animal Science and Technology, Chongqing Key Laboratory of Herbivore Science, Southwest University, Chongqing, China., Zhao Z; College of Animal Science and Technology, Chongqing Key Laboratory of Herbivore Science, Southwest University, Chongqing, China., Zhao Y; College of Animal Science and Technology, Chongqing Key Laboratory of Herbivore Science, Southwest University, Chongqing, China., Chen J; College of Animal Science and Technology, Chongqing Key Laboratory of Herbivore Science, Southwest University, Chongqing, China. Electronic address: juncaichen@swu.edu.cn. |
| Source: | Bioresource technology [Bioresour Technol] 2026 Jul; Vol. 452, pp. 134610. Date of Electronic Publication: 2026 Apr 12. |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: Elsevier Applied Science Country of Publication: England NLM ID: 9889523 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2976 (Electronic) Linking ISSN: 09608524 NLM ISO Abbreviation: Bioresour Technol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Barking, Essex, England : New York, N.Y. : Elsevier Applied Science ; Elsevier Science Pub. Co., 1991- |
| MeSH Terms: | Manure*/microbiology , Drug Resistance, Microbial*/genetics , Anti-Bacterial Agents* , Livestock*, Animals ; Anaerobiosis |
| Abstract: | Livestock manure is a primary reservoir of antibiotics and antibiotic resistance genes (ARGs). While anaerobic digestion (AD) is the standard technology for waste stabilization, its capacity to contain biological contaminants remains limited. This review provides a quantitative assessment of validated manure management strategies based on a dataset of 189 observations from peer-reviewed studies. The analysis confirms that AD functions as a semi-permeable barrier. It effectively degrades antibiotic residues, but the attenuation of ARGs is variable and often inefficient. This leads to their enrichment in the solid digestate. We further identify a technological gap between laboratory-scale efficiency and industrial feasibility, particularly regarding nanomaterial additives. To address these limitations, an integrated multi-barrier framework is proposed. This comprises upstream source control, process intensification, and downstream sanitization. We critically evaluate the efficacy of specific engineering interventions, including thermal and chemical pretreatments, functional additives such as zero-valent iron and biochar, and post-treatment technologies like autothermal bio-drying. The review suggests that ensuring ecological biosafety requires integrating these unit operations rather than optimizing them in isolation. Finally, future research needs are identified, focusing on precise host-tracking to distinguish ecological risks and the necessity for quantitative life-cycle assessments to validate the economic viability of full-scale implementation. (Copyright © 2026 Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Anaerobic digestion; Animal manure; Antibiotic resistance genes; Functional additives; Process optimization |
| Substance Nomenclature: | 0 (Manure) 0 (Anti-Bacterial Agents) |
| Entry Date(s): | Date Created: 20260414 Date Completed: 20260715 Latest Revision: 20260715 |
| Update Code: | 20260715 |
| DOI: | 10.1016/j.biortech.2026.134610 |
| PMID: | 41980644 |
| Database: | MEDLINE |
| ISSN: | 1873-2976 |
|---|---|
| DOI: | 10.1016/j.biortech.2026.134610 |