A novel solid-phase extraction approach based on π-conjugated polymer-functionalized mesoporous silica nanoparticles for isoquinoline alkaloid purification from Cinnamomum camphora seed kernels.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	A novel solid-phase extraction approach based on π-conjugated polymer-functionalized mesoporous silica nanoparticles for isoquinoline alkaloid purification from Cinnamomum camphora seed kernels.
Συγγραφείς:	Yang Y; School of Chemistry and Chemical Engineering, Nanchang University, Nanchang 330031, China; State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China. Electronic address: 17698319443@163.com., Yu P; School of Chemistry and Chemical Engineering, Nanchang University, Nanchang 330031, China; State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China. Electronic address: cpu_yuping@126.com., Zeng Z; State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China; School of Food Science and Technology, Nanchang University, Nanchang 330031, China. Electronic address: zlzengjx@163.com., Gao X; School of Chemistry and Chemical Engineering, Nanchang University, Nanchang 330031, China; State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China. Electronic address: 352800230033@email.ncu.edu.cn., Gao Y; School of Chemistry and Chemical Engineering, Nanchang University, Nanchang 330031, China; State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China. Electronic address: gyf10107329@163.com., Cheng D; School of Chemistry and Chemical Engineering, Nanchang University, Nanchang 330031, China; State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China. Electronic address: dingchenghn@163.com., Zeng C; Institute for Transformative Molecular Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA. Electronic address: cxz593@case.edu., Wen X; Institute of Applied Chemistry, Jiangxi Academy of Science, Nanchang, 330096, China. Electronic address: xuefang@live.cn., Gong D; School of Chemistry and Chemical Engineering, Nanchang University, Nanchang 330031, China; State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China; New Zealand Institute of Natural Medicine Research, 8 Ha Crescent, Auckland 2104, New Zealand. Electronic address: dgong01@gmail.com., Yan X; State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China; School of Food Science and Technology, Nanchang University, Nanchang 330031, China. Electronic address: xianghui_y@163.com.
Πηγή:	Journal of chromatography. A [J Chromatogr A] 2026 Jun 21; Vol. 1777, pp. 466988. Date of Electronic Publication: 2026 Apr 09.
Τύπος έκδοσης:	Journal Article
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9318488 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3778 (Electronic) Linking ISSN: 00219673 NLM ISO Abbreviation: J Chromatogr A Subsets: MEDLINE
Imprint Name(s):	Original Publication: Amsterdam ; New York : Elsevier, 1993-
Ιατρικοί όροι (MeSH):	Silicon Dioxide/chemistry , Alkaloids/isolation & purification , Alkaloids/chemistry , Alkaloids/analysis , Seeds/chemistry , Solid Phase Extraction/methods , Solid Phase Extraction/instrumentation , Cinnamomum camphora/chemistry , Isoquinolines/isolation & purification , Isoquinolines/chemistry , Nanoparticles*/chemistry, Polymers/chemistry ; Adsorption ; Porosity
Περίληψη:	A new class of π-conjugated polymer-functionalized porous silica adsorbents, including a non-carbonized material (SiO2@π-CP) and its carbonized derivative (SiO2@C-π-CP), was developed through a simple, low-cost synthetic strategy. For the first time, these materials were applied as solid-phase extraction (SPE) sorbents for selective purification of four isoquinoline alkaloids, magnoflorine, laurifoline, lindoldhamine and N-methyldomesticinium, from Cinnamomum camphora seed kernels (CCSK). The integration of π-conjugated polymers with porous silica created abundant adsorption sites, enabling synergistic π-π, electrostatic and hydrogen-bonding interactions, and thus significantly enhancing CCSK alkaloid affinity. Comprehensive characterization confirmed successful functionalization and structural stability. Under optimized static conditions, SiO2@π-CP and SiO2@C-π-CP exhibited high adsorption capacities of 68.57 and 97.83 mg g⁻¹, respectively, for total CCSK alkaloids, with adsorption behavior well described by pseudo-second-order kinetic and the Freundlich isotherm. Notably, carbonization significantly improved adsorption performance, chemical robustness, and reusability, with both materials maintaining high efficiency after eight adsorption-desorption cycles. Furthermore, SiO2@C-π-CP was successfully implemented as a dynamic SPE sorbent, with column adsorption behavior accurately predicted by Adams-Bohart, Thomas, Yoon-Nelson, and BDST models, providing a practical basis for scale-up. Following SPE purification, the purity of CCSK alkaloid increased from 32.97% to 61.59%, with a yield of 73.54%. This work introduces a novel π-conjugated polymer-based SPE platform that combines high selectivity, robustness and scalability, offering a promising strategy for efficient plant alkaloids purification. (Copyright © 2026 Elsevier B.V. All rights reserved.)
Competing Interests:	Declaration of competing interest All authors declare that there is no conflict of interest related to this paper.
Contributed Indexing:	Keywords: Adsorbent; Cinnamomum camphora seed kernel; Isoquinoline alkaloid; Purification; Solid phase extraction
Substance Nomenclature:	7631-86-9 (Silicon Dioxide) 0 (Alkaloids) 0 (Isoquinolines) 0 (Polymers)
Entry Date(s):	Date Created: 20260414 Date Completed: 20260715 Latest Revision: 20260715
Update Code:	20260715
DOI:	10.1016/j.chroma.2026.466988
PMID:	41980485
Βάση Δεδομένων:	MEDLINE

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Περιγραφή
ISSN:	1873-3778
DOI:	10.1016/j.chroma.2026.466988