Academic Journal
Multi-dimensional recovery trajectories in cannabis-induced psychosis: A systematic review examining symptomatic, functional, cognitive, and subjective outcomes.
| Τίτλος: | Multi-dimensional recovery trajectories in cannabis-induced psychosis: A systematic review examining symptomatic, functional, cognitive, and subjective outcomes. |
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| Συγγραφείς: | Ricci V; University of Turin, San Luigi Gonzaga Hospital, Regione Gonzole, 10, Orbassano 10043, Italy. Electronic address: valerio.ricci@unito.it., Sarni A; University of Turin, San Luigi Gonzaga Hospital, Regione Gonzole, 10, Orbassano 10043, Italy; Department of Neurosciences 'Rita Levi Montalcini', University of Turin, Via Cherasco 15, 10126, Italy., Barresi M; University of Turin, San Luigi Gonzaga Hospital, Regione Gonzole, 10, Orbassano 10043, Italy; Department of Neurosciences 'Rita Levi Montalcini', University of Turin, Via Cherasco 15, 10126, Italy., Remondino L; University of Turin, San Luigi Gonzaga Hospital, Regione Gonzole, 10, Orbassano 10043, Italy; Department of Neurosciences 'Rita Levi Montalcini', University of Turin, Via Cherasco 15, 10126, Italy., Maina G; University of Turin, San Luigi Gonzaga Hospital, Regione Gonzole, 10, Orbassano 10043, Italy; Department of Neurosciences 'Rita Levi Montalcini', University of Turin, Via Cherasco 15, 10126, Italy. |
| Πηγή: | Asian journal of psychiatry [Asian J Psychiatr] 2026 Jun; Vol. 120, pp. 104975. Date of Electronic Publication: 2026 Apr 10. |
| Τύπος έκδοσης: | Systematic Review; Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101517820 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-2026 (Electronic) Linking ISSN: 18762018 NLM ISO Abbreviation: Asian J Psychiatr Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Amsterdam] : Elsevier |
| Ιατρικοί όροι (MeSH): | Psychoses, Substance-Induced*/physiopathology , Psychoses, Substance-Induced*/therapy , Outcome Assessment, Health Care*, Humans |
| Περίληψη: | Background: Cannabis-induced psychotic disorders represent 12-35% of first-episode psychosis presentations globally. Traditional clinical wisdom holds these conditions carry favorable prognosis based on rapid symptomatic improvement, yet this narrative rests almost exclusively on symptomatic outcomes, overlooking functional, cognitive, and subjective recovery dimensions. Objective: To systematically review multi-dimensional recovery trajectories following cannabis-induced or cannabis-associated first-episode psychosis, characterizing patterns of concordance and discordance across outcome domains and identifying predictors of recovery profiles. Methods: We searched five databases (PubMed/MEDLINE, PsycINFO, Embase, Web of Science, Cochrane Library) from inception to December 2024. Inclusion Criteria: longitudinal studies (≥6 months follow-up) assessing ≥ 2 outcome domains among symptomatic, functional, cognitive, and subjective recovery in cannabis-induced first-episode psychosis. Two independent reviewers screened studies and assessed quality using Newcastle-Ottawa Scale. Data were synthesized narratively. Results: Thirty-three studies encompassing 18,117 participants were included (mean follow-up 24 months, range 6 months-10 years). While 50-70% achieved symptomatic remission within 6 months, functional recovery revealed substantial heterogeneity and frequent symptom-function dissociation. Continued cannabis use emerged as strongest predictor of poor outcomes across domains (persistence rates 35-65%), though cessation demonstrated significant benefits (functional recovery effect size 1.26). Cognitive findings were heterogeneous, and subjective outcomes remained poorly characterized (assessed in only 38% of studies). Only 15% of studies employed person-centered trajectory modeling, revealing five distinct recovery profiles. Conclusions: Symptomatic improvement frequently fails to translate into functional recovery following cannabis-induced psychosis. The field's understanding of "favorable prognosis" inadequately captures comprehensive multi-dimensional recovery, necessitating interventions targeting functional, cognitive, and subjective domains beyond symptomatic remission. (Copyright © 2026 The Authors. Published by Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of Competing Interest All authors declare no conflicts of interest related to this work. No financial support or other benefits from commercial sources were received for the work reported in the manuscript. The authors have no financial interests that could create a potential conflict of interest or the appearance of a conflict of interest with regard to the work. |
| Contributed Indexing: | Keywords: Cannabis-induced psychosis; Cognitive function; First-episode psychosis; Functional outcomes; Recovery trajectories; Subjective recovery |
| Entry Date(s): | Date Created: 20260414 Date Completed: 20260526 Latest Revision: 20260528 |
| Update Code: | 20260529 |
| DOI: | 10.1016/j.ajp.2026.104975 |
| PMID: | 41980405 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1876-2026 |
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| DOI: | 10.1016/j.ajp.2026.104975 |