Academic Journal
A Narrative Review of the Regional Prospective Observational Research in Tuberculosis International Consortium: Sharing Diverse Data and Specimens in the Fight Against Tuberculosis.
| Τίτλος: | A Narrative Review of the Regional Prospective Observational Research in Tuberculosis International Consortium: Sharing Diverse Data and Specimens in the Fight Against Tuberculosis. |
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| Συγγραφείς: | Bhavaraju R; Department of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA., Andrade B; Fundação Oswaldo Cruz, Salvador, Brazil.; Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA., Siminski S; Frontier Science Foundation, Amherst, NewYork, USA., Kim S; Frontier Science Foundation, Amherst, NewYork, USA., Hatherill M; University of Cape Town, Cape Town, South Africa., Sterling T; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Gupta A; Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA., Martin D; Department of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA., Sarkar S; Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India., Alejandria M; University of the Philippines, Manila, Philippines., Ellner JJ; Department of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA. |
| Πηγή: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2026 Apr 13; Vol. 82 (Suppl 2), pp. S53-S59. |
| Τύπος έκδοσης: | Journal Article; Review; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE |
| Imprint Name(s): | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: Chicago, IL : The University of Chicago Press, c1992- |
| Ιατρικοί όροι (MeSH): | Tuberculosis*/diagnosis , Tuberculosis*/drug therapy , Tuberculosis*/epidemiology , Tuberculosis*/prevention & control, Humans ; Prospective Studies ; Observational Studies as Topic ; International Cooperation ; Mycobacterium tuberculosis ; Biomedical Research ; United States ; National Institute of Allergy and Infectious Diseases (U.S.) ; India |
| Περίληψη: | Background: Clinical tuberculosis (TB) research has been hampered by a lack of reliable predictors of Mycobacterium tuberculosis infection progression and active TB treatment's cure, relapse, and failure. Given host and bacterial variability, large sample sizes from harmonized datasets are needed to study infrequent endpoints. Therefore, global observational research consortia, such as Regional Prospective Observational Research in Tuberculosis (RePORT) International (RI), can help make meaningful inroads into successful TB prevention, diagnosis, and treatment. Methods: RePORT International was created in 2012 by the US National Institute of Allergy and Infectious Diseases (NIAID) with bilateral country funding. The Consortium's country networks (Brazil, India, Indonesia, Korea, Philippines, South Africa, and Uganda) use a common protocol to recruit for 2 participant cohorts (active TB and close contacts). A coordinating center, led by a multinational executive committee, provides early-stage investigator research and mentorship opportunities, guidance on quality-assured data and specimen collection, and scientific direction while allowing networks to pursue geographically relevant research and implementation. Results: Consortium biorepositories house 632 000+ specimens with associated epidemiological data from ∼11 900 participants. There have been 67 country- and consortium-wide projects via multiple funding sources, resulting in about 200 publications covering epidemiology, drug resistance, biomarkers, comorbidities, transcriptomics, diagnostics, and immunology. Capacity building is conducted through research fellowships and collaborations with other consortia including with a public resource database and data/specimen dashboard. Conclusions: Public health research has had funding limitations on ideal patient enrollment and follow-up, as well as the maintenance of research infrastructure and personnel. However, RI is well prepared to meet these challenges while supporting better point-of-care diagnostics, screening for asymptomatic TB, post-TB care, and successful treatment outcomes. (© The Author(s) 2026. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.) |
| Competing Interests: | Potential conflicts of interest. The authors receive partial salary support from the National Institutes of Health award number U01AI174268. |
| References: | Am J Public Health. 2009 Apr;99 Suppl 1:S5-7. (PMID: 19246666) J Healthc Leadersh. 2017 Jul 28;9:59-67. (PMID: 29355238) Prev Chronic Dis. 2011 May;8(3):A70. (PMID: 21477510) Am J Public Health. 2001 Dec;91(12):1938-43. (PMID: 11726369) Clin Infect Dis. 2015 Oct 15;61Suppl 3:S155-9. (PMID: 26409277) Contemp Clin Trials. 2022 May;116:106572. (PMID: 34583056) PLoS Negl Trop Dis. 2009;3(3):e345. (PMID: 19333368) Invest Ophthalmol Vis Sci. 2014 May 27;55(5):3219-22. (PMID: 24867910) Clin Infect Dis. 2023 Apr 17;76(8):1483-1491. (PMID: 36424864) Acad Med. 2011 Nov;86(11):1360-6. (PMID: 21952064) Virchows Arch. 2016 Jan;468(1):93-9. (PMID: 26271995) Res Nurs Health. 2017 Feb;40(1):63-69. (PMID: 27686332) Front Immunol. 2023 Aug 29;14:1234785. (PMID: 37795102) Lancet Microbe. 2026 Feb;7(2):101279. (PMID: 41448216) |
| Grant Information: | U01 AI174268 United States AI NIAID NIH HHS; United States NH NIH HHS; Regional Prospective Observational Research for Tuberculosis (RePORT); International Coordinating Center (RICC) |
| Contributed Indexing: | Keywords: biomarker; observational research; tuberculosis |
| Entry Date(s): | Date Created: 20260413 Date Completed: 20260714 Latest Revision: 20260821 |
| Update Code: | 20260821 |
| PubMed Central ID: | PMC13075813 |
| DOI: | 10.1093/cid/ciag151 |
| PMID: | 41974034 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1537-6591 |
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| DOI: | 10.1093/cid/ciag151 |