Academic Journal
Click chemistry charts covalent drug landscapes in vivo.
| Τίτλος: | Click chemistry charts covalent drug landscapes in vivo. |
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| Συγγραφείς: | Wang W; Laboratory of Cellular Metabolism and Precision Therapeutics, School of Life Sciences and Technology, Northwestern Polytechnical University, Xi'an 710129, China; Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518057, China., Liu Y; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: y.liu@syphu.edu.cn., Wei G; Laboratory of Cellular Metabolism and Precision Therapeutics, School of Life Sciences and Technology, Northwestern Polytechnical University, Xi'an 710129, China; Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518057, China. Electronic address: weigf0605@163.com. |
| Πηγή: | Trends in pharmacological sciences [Trends Pharmacol Sci] 2026 Jun; Vol. 47 (6), pp. 584-586. Date of Electronic Publication: 2026 Apr 11. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Published By Elsevier In Association With The International Union Of Pharmacology Country of Publication: England NLM ID: 7906158 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3735 (Electronic) Linking ISSN: 01656147 NLM ISO Abbreviation: Trends Pharmacol Sci Subsets: MEDLINE |
| Imprint Name(s): | Publication: Barking : Published By Elsevier In Association With The International Union Of Pharmacology Original Publication: Amsterdam, Published by Elsevier in association with the International Union of Pharmacology. |
| Ιατρικοί όροι (MeSH): | Click Chemistry*/methods, Pharmaceutical Preparations/chemistry ; Pharmaceutical Preparations/metabolism ; Animals ; Humans |
| Περίληψη: | Covalent drugs display rich in vivo reactivity landscapes that remain largely unmapped. A recent Cell study by Pang et al. introduces vCATCH (volumetric clearing-assisted tissue click chemistry), a chemistry-driven platform combining clickable probes, bioorthogonal ligation, and whole-body imaging to chart covalent drug-target interactions across intact organisms. (Copyright © 2026 Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of interests The authors declare no competing interests. |
| Contributed Indexing: | Keywords: bioorthogonal ligation; click chemistry; covalent inhibitors; vCATCH; whole-body imaging |
| Substance Nomenclature: | 0 (Pharmaceutical Preparations) |
| Entry Date(s): | Date Created: 20260412 Date Completed: 20260610 Latest Revision: 20260610 |
| Update Code: | 20260611 |
| DOI: | 10.1016/j.tips.2026.03.005 |
| PMID: | 41968008 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1873-3735 |
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| DOI: | 10.1016/j.tips.2026.03.005 |