Academic Journal
E-selectin-targeted microbubbles combined with ultrasound improves renoprotective effects of methylprednisolone on cisplatin-induced acute kidney injury in rats.
| Τίτλος: | E-selectin-targeted microbubbles combined with ultrasound improves renoprotective effects of methylprednisolone on cisplatin-induced acute kidney injury in rats. |
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| Συγγραφείς: | Si R; Department of Ophthalmology, Second Affiliated Hospital, Xi'an Jiaotong University Health Science Center, Xi'an, 710004, People's Republic of China., Mo L; Department of Pathology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, People's Republic of China., Zhao C; Department of Pathology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, People's Republic of China., Xu Z; Department of Pathology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, People's Republic of China., Zhao W; Department of Pathology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, People's Republic of China., Wu J; Department of Pathology, School of Basic Medicine and Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, People's Republic of China., Fu R; Department of Nephrology, Second Affiliated Hospital, Xi'an Jiaotong University Health Science Center, Xi'an, 710004, People's Republic of China. pipifu@126.com.; Nephrology & Critical Care Medicine of Xi'an International Science and Technology Cooperation Base, Xi'an, 710004, People's Republic of China. pipifu@126.com., Ren S; Department of Pathology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, People's Republic of China. rst@mail.xjtu.edu.cn.; Department of Nephrology, Second Affiliated Hospital, Xi'an Jiaotong University Health Science Center, Xi'an, 710004, People's Republic of China. rst@mail.xjtu.edu.cn. |
| Πηγή: | Scientific reports [Sci Rep] 2026 Apr 11; Vol. 16 (1). Date of Electronic Publication: 2026 Apr 11. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : Nature Publishing Group, copyright 2011- |
| Ιατρικοί όροι (MeSH): | Microbubbles*/therapeutic use , E-Selectin*/metabolism , Acute Kidney Injury*/chemically induced , Acute Kidney Injury*/metabolism , Acute Kidney Injury*/drug therapy , Acute Kidney Injury*/pathology , Acute Kidney Injury*/therapy , Cisplatin*/adverse effects , Methylprednisolone*/pharmacology , Methylprednisolone*/administration & dosage, Kidney/drug effects ; Kidney/metabolism ; Kidney/pathology ; Drug Delivery Systems/methods ; Anti-Inflammatory Agents/pharmacology ; Animals ; Rats ; Male ; Rats, Sprague-Dawley ; Disease Models, Animal |
| Περίληψη: | Our previous study showed that the functionalized E-selectin targeted MBs (TMB-E−selectin) may become a novel drug delivery vector for inflammatory diseases. Therefore, the purpose of this study was to investigate the effect of TMB-E−selectin and methylprednisolone (MP) co-administration combined with ultrasound (US) on cisplatin-induced acute kidney injury (AKI) in rats. After modeling with a single intraperitoneal injection of 10 mg/kg of cisplatin, the rats were intravenously administered with MP or TMB-E−selectin alone, or their mixtures. US was immediately applied for 10 min on bilateral kidneys in rats with TMB-E−selectin treatment. Results showed that 50 mg/kg MP alone and the mixture of 20 mg/kg MP and 500 µL/kg TMB-E−selectin combined with US significantly reduced the levels of BUN and Scr, renal injuries, and the expressions of E-selectin, IL-1α, TNF-α, and NF-κB in renal tissues, but these therapy effects were not significantly observed by 20 mg/kg MP alone. In conclusion, TMB-E−selectin combined with US can enhance the anti-inflammatory and renoprotective effects of the MP in rats with AKI then decrease systemic required dosage and improve the bioavailability of glucocorticoids, which mechanism mainly associates with local drug delivery mediated by US targeted microbubbles cavitation. |
| Competing Interests: | Declarations. Competing interests: The authors declare no competing interests. |
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| Grant Information: | 82070792 the National Natural Science Foundation of China |
| Contributed Indexing: | Keywords: Acute kidney injury; Drug delivery; E-selectin-targeted lipid microbubbles; Glucocorticoids; Ultrasound targeted microbubbles cavitation |
| Substance Nomenclature: | 0 (E-Selectin) Q20Q21Q62J (Cisplatin) X4W7ZR7023 (Methylprednisolone) 0 (Anti-Inflammatory Agents) |
| Entry Date(s): | Date Created: 20260411 Date Completed: 20260628 Latest Revision: 20260813 |
| Update Code: | 20260813 |
| PubMed Central ID: | PMC13230692 |
| DOI: | 10.1038/s41598-026-47547-x |
| PMID: | 41965449 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2045-2322 |
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| DOI: | 10.1038/s41598-026-47547-x |