Academic Journal
Molecular architecture of Influenza A virions.
| Τίτλος: | Molecular architecture of Influenza A virions. |
|---|---|
| Συγγραφείς: | Vijayakrishnan S; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Hirst JC; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Cole S; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Hester SS; Discovery Proteomics Facility, Nuffield Department of Medicine, University of Oxford, UK., Sreenu VB; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Loney C; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Kamel W; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Fischer R; Discovery Proteomics Facility, Nuffield Department of Medicine, University of Oxford, UK., Smith TK; Biomedical Science Research Centre, School of Biology, University of St Andrews, St Andrews, UK., Autin L; Scripps Research Institute, Torrey Pines Rd, La Jolla, CA, USA., Bhella D; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Hutchinson E; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK. |
| Πηγή: | BioRxiv : the preprint server for biology [bioRxiv] 2026 Apr 02. Date of Electronic Publication: 2026 Apr 02. |
| Τύπος έκδοσης: | Journal Article; Preprint |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| Περίληψη: | Influenza A viruses (IAV) are clinically important pathogens that cause seasonal epidemics and pandemics in humans. IAV produce pleomorphic, enveloped virions, which can range from a spherical or bacilliform morphology, the predominant form in the most commonly studied laboratory strains, to long filamentous virions which are characteristic of clinical and veterinary isolates. Understanding the structure and function of filamentous virions is crucial for clarifying their role in viral persistence and immune evasion, and for informing the development of therapeutics that target their entry and/or egress pathways. Structural characterisation of influenza virions is challenging however owing to their fragility, heterogeneity and compared to most virus particles, unusually large size. Here, we combined structural and compositional approaches with integrative modelling to define the complete molecular architecture of influenza virions. In doing so we provide the first description of distinctive structural features of IAV filaments, including the selective incorporation of lipids, specific enrichment of viral and host proteins, and a viral cytoskeleton including a secondary helical layer within the viral capsid and extended fibrils of cofilactin. Collectively our findings suggest an important regulatory role for cofilactin in driving filament morphogenesis and provide important insights into the organisation and composition of IAV filamentous virions. |
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| Grant Information: | R01 GM120604 United States GM NIGMS NIH HHS; U54 AI170855 United States AI NIAID NIH HHS |
| Entry Date(s): | Date Created: 20260410 Date Completed: 20260427 Latest Revision: 20260922 |
| Update Code: | 20260922 |
| PubMed Central ID: | PMC13060464 |
| DOI: | 10.64898/2026.04.02.715802 |
| PMID: | 41959045 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2692-8205 |
|---|---|
| DOI: | 10.64898/2026.04.02.715802 |