Academic Journal
Comparative Clinical Trajectories Across Cannabis-Related and Nonsubstance-Related Psychoses.
| Τίτλος: | Comparative Clinical Trajectories Across Cannabis-Related and Nonsubstance-Related Psychoses. |
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| Συγγραφείς: | Mustonen A; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Department of Psychiatry, Seinäjoki Central Hospital, Seinäjoki, Finland., Niemelä S; Department of Psychiatry, Faculty of Medicine, University of Turku, Turku, Finland.; Mental Health and Addiction Services, Wellbeing County of South-West Finland, Turku, Finland., Denissoff A; Department of Psychiatry, Faculty of Medicine, University of Turku, Turku, Finland.; Mental Health and Addiction Services, Wellbeing County of South-West Finland, Turku, Finland., Tanskanen A; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Eastern Finland, Kuopio, Finland., Mittendorfer-Rutz E; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden., Lähteenvuo M; Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Eastern Finland, Kuopio, Finland., Tiihonen J; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Eastern Finland, Kuopio, Finland.; Neuroscience Center, University of Helsinki, Helsinki, Finland.; Center for Psychiatry Research, Stockholm Region, Stockholm, Sweden., Taipale H; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Eastern Finland, Kuopio, Finland.; School of Pharmacy, University of Eastern Finland, Kuopio, Finland. |
| Πηγή: | Acta psychiatrica Scandinavica [Acta Psychiatr Scand] 2026 Aug; Vol. 154 (2), pp. 142-152. Date of Electronic Publication: 2026 Apr 08. |
| Τύπος έκδοσης: | Journal Article; Comparative Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 0370364 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0447 (Electronic) Linking ISSN: 0001690X NLM ISO Abbreviation: Acta Psychiatr Scand Subsets: MEDLINE |
| Imprint Name(s): | Publication: Malden, MA : Wiley-Blackwell Original Publication: Copenhagen : Munksgaard International Publishers |
| Ιατρικοί όροι (MeSH): | Marijuana Abuse*/epidemiology , Psychoses, Substance-Induced*/epidemiology , Psychotic Disorders*/epidemiology , Substance-Related Disorders*/epidemiology, Sweden/epidemiology ; Hospitalization/statistics & numerical data ; Registries/statistics & numerical data ; Schizophrenia/epidemiology ; Humans ; Adult ; Male ; Female ; Young Adult ; Prevalence |
| Περίληψη: | Background: Research indicates that first-episode psychosis (FEP) with cannabis use disorder (CUD) carries a substantial disease burden, but more granular clinical trajectories of cannabis-related psychoses remain unclear. This study examines the clinical trajectories of first clinically diagnosed FEP&CUD and cannabis-induced psychosis (CIP) in comparison with FEP without substance use disorder (SUD). Methods: From the linkage of nationwide administrative and medical registers of Sweden (2006-2021), we identified 1772 individuals (84.1% men) with incident CIP, 1360 individuals (84.3% men) with FEP&CUD and matched individuals with FEP but without SUD and followed them up until 2023. We compared annual prevalence of psychiatric diagnoses before and after cohort entry, medication use, days in inpatient care, and the risks of hospitalization for psychosis and death. Results: Mean age at first diagnosis was 26.6 years (SD 8.3) for incident CIP and 26.9 years (SD 8.4) for FEP&CUD and FEP without SUD. Individuals in the FEP without SUD cohort were more likely to have a record of schizophrenia diagnosis compared to the FEP&CUD and CIP cohorts during the first (14.41%, 6.25%, 2.37%) and second year (10.88%, 7.13%, 3.27%) after cohort entry. However, FEP&CUD and CIP cohorts had a more pronounced burden of inpatient treatment as well as elevated risks of hospitalization for psychosis (aHR = 1.66; 95% CI 1.49-1.86 and aHR = 1.47; 1.32-1.64) and death (aHR = 2.02; 1.44-2.82 and aHR = 1.80; 1.30-2.50) compared to individuals with FEP without SUD. Conclusions: Cannabis-related psychoses, that is, FEP&CUD and CIP, were associated with poor outcomes, including high risk of hospitalization for psychosis and increased mortality, underscoring the need for targeted interventions. Moreover, the overlapping clinical trajectories suggest that cannabis-related psychoses may not represent clinically distinct entities but instead lie on a continuum. (© 2026 The Author(s). Acta Psychiatrica Scandinavica published by John Wiley & Sons Ltd.) |
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| Grant Information: | 2021-00154 Vetenskapsrådet; 2024-03340 Vetenskapsrådet; Juho Vainion Säätiö; Alkoholitutkimussäätiö; State funding for university- level health research, Tampere University Hospital |
| Contributed Indexing: | Keywords: cannabis‐induced psychosis; first‐episode psychosis; hospitalization; mortality; outcome; register study; trajectory |
| Entry Date(s): | Date Created: 20260409 Date Completed: 20260702 Latest Revision: 20260813 |
| Update Code: | 20260813 |
| PubMed Central ID: | PMC13327216 |
| DOI: | 10.1111/acps.70097 |
| PMID: | 41952346 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1600-0447 |
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| DOI: | 10.1111/acps.70097 |