Academic Journal
A guide to using embedded ethics in human stem-cell-based embryo model research.
| Τίτλος: | A guide to using embedded ethics in human stem-cell-based embryo model research. |
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| Συγγραφείς: | Bentzen HB; Centre for Medical Ethics, Faculty of Medicine, University of Oslo, Oslo, Norway. h.b.bentzen@medisin.uio.no.; Cancer Registry of Norway, Norwegian Institute of Public Health, Oslo, Norway. h.b.bentzen@medisin.uio.no., Gaillard M; Centre for Medical Ethics, Faculty of Medicine, University of Oslo, Oslo, Norway.; Institut Supérieur de Philosophie, UCLouvain, Louvain-la-Neuve, Belgium., Nachman I; School of Neurobiology, Biochemistry and Biophysics, Tel Aviv University, Tel Aviv, Israel., Reumann D; Kavli Institute for Nanoscience Discovery, Department of Physiology, Anatomy & Genetics (DPAG), University of Oxford, Oxford, UK., Gadegaard N; James Watt School of Engineering, University of Glasgow, Glasgow, UK., David L; Nantes Université, CHU Nantes, Inserm, CR2TI, Nantes, France.; Nantes Université, CHU Nantes, CNRS, Inserm, BioCore, Nantes, France.; CHU Nantes, Service de Médecine et Biologie de la Reproduction, Nantes, France., Lanner F; Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.; Division of Obstetrics and Gynecology, Karolinska Universitetssjukhuset, Stockholm, Sweden., Moris N; The Francis Crick Institute, London, UK., Pasque V; Department of Development and Regeneration, Leuven Institute for Single-cell Omics (LISCO), KU Leuven-University of Leuven, Leuven, Belgium., Rivron N; Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna Biocenter, Vienna, Austria., Sozen B; Department of Genetics, Yale School of Medicine, Yale University, New Haven, CT, USA., Isasi R; Institute for Bioethics and Health Policy and Dr. John T. Macdonald Foundation Department of Human Genetics, Miami, FL, USA., Krauss S; Hybrid Technology Hub-Centre of Excellence, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway. s.j.k.krauss@medisin.uio.no.; Department of Immunology and Transfusion Medicine, Oslo University Hospital, Oslo, Norway. s.j.k.krauss@medisin.uio.no., Veenvliet JV; Stembryogenesis Lab, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany. veenvliet@mpi-cbg.de.; Center for Systems Biology Dresden, Dresden, Germany. veenvliet@mpi-cbg.de.; Cluster of Excellence Physics of Life, Technische Universität Dresden, Dresden, Germany. veenvliet@mpi-cbg.de. |
| Πηγή: | Nature cell biology [Nat Cell Biol] 2026 Apr; Vol. 28 (4), pp. 665-673. Date of Electronic Publication: 2026 Apr 08. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : Macmillan Magazines Ltd., [1999- |
| Ιατρικοί όροι (MeSH): | Embryo Research*/ethics , Stem Cell Research*/ethics , Models, Biological* , Human Embryonic Stem Cells*, Humans |
| Περίληψη: | Human stem-cell-based embryo models (hSCBEMs) offer unprecedented opportunities for basic and translational research. However, the rapid pace of scientific developments in the field challenges the slower, traditional modes of ethics evaluation. To facilitate responsible research and governance, and ensure public trust, we propose using 'embedded ethics' as a purpose-anchored, dynamic, iterative and integrative approach where ethicists and scientists engage in continuous dialogue to ethically assess ongoing research. We outline a nested benchmarking strategy to periodically evaluate the scientific and ethical status of hSCBEMs within a project, using the human embryo as a reference and weighting criteria along a hierarchy of features that chart embryo-likeness, completeness and the developmental stage modelled. Embedded ethics guides the definition of decision points and ethical boundaries through an iterative assessment of project purpose and ethical and regulatory frameworks, and enables early identification of emerging issues and the co-construction of responsible paths forward. (© 2026. Springer Nature Limited.) |
| Competing Interests: | Competing interests: The KU Leuven, Belgium has filed a patent application (PCT/EP2023/073949). V.P. is one of the inventors on this patent. N.M. is an inventor on patents PCT/GB2019/052670 and PCT/GB2019/052668 owned by Cambridge Enterprise. N.R. is an inventor on the patents ‘Blastoid, cell line based artificial blastocyst’ (EP2986711) and ‘Blastocyst-like cell aggregate and methods’ (EP21151455.9). The remaining authors declare no competing interests. |
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| Grant Information: | n/a Max-Planck-Gesellschaft (Max Planck Society); BB/Y00311X/1 RCUK | Biotechnology and Biological Sciences Research Council (BBSRC); 101002317 EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) |
| Entry Date(s): | Date Created: 20260408 Date Completed: 20260714 Latest Revision: 20261010 |
| Update Code: | 20261010 |
| DOI: | 10.1038/s41556-026-01909-9 |
| PMID: | 41951755 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1476-4679 |
|---|---|
| DOI: | 10.1038/s41556-026-01909-9 |