Academic Journal
Demographic Reporting and Representation Among Neurosurgical Clinical Trials in the United States.
| Τίτλος: | Demographic Reporting and Representation Among Neurosurgical Clinical Trials in the United States. |
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| Συγγραφείς: | Daulat SR; Department of Neurosurgery, University of Arizona College of Medicine-Tucson, Tucson, Arizona, USA., Dholaria N; Department of Neurosurgery, University of Arizona College of Medicine-Phoenix, Phoenix, Arizona, USA., Patil S; Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA., Wakelin S; Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA., Zeeshan Q; Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA. Electronic address: drzeeshanqazi@gmail.com., Pilitsis JG; Department of Neurosurgery, University of Arizona College of Medicine-Tucson, Tucson, Arizona, USA. |
| Πηγή: | World neurosurgery [World Neurosurg] 2026 Jun; Vol. 210, pp. 124973. Date of Electronic Publication: 2026 Apr 04. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: United States NLM ID: 101528275 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-8769 (Electronic) Linking ISSN: 18788750 NLM ISO Abbreviation: World Neurosurg Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: New York : Elsevier |
| Ιατρικοί όροι (MeSH): | Clinical Trials as Topic*/statistics & numerical data , Demography* , Neurosurgical Procedures* , Neurosurgery*, Ethnicity/statistics & numerical data ; Racial Groups/statistics & numerical data ; Humans ; United States ; Female ; Male ; Middle Aged ; Adult ; White ; Workforce Diversity |
| Περίληψη: | Objective: The purpose of this study is to evaluate trends in the reporting and representation of sex, race, and ethnicity across neurosurgical clinical trials. Methods: A comprehensive analysis of U.S. neurosurgical clinical trials registered on ClinicalTrials.gov was conducted in August 1, 2025. A total of 317 completed neurosurgical clinical trials with posted results were included. Trials were categorized by neurosurgical subspecialty, sponsorship, phase, sample size, study period, and age eligibility. The primary outcomes were reporting and representation of sex, race, and ethnicity. Wilcoxon signed-rank tests and paired t-tests were conducted to assess representation compared to the annual state census demographic data. Linear and multivariate regressions were conducted to assess temporal trends and trial characteristics' influence over representation and reporting. Results: Among 317 neurosurgical clinical trials, the mean participant age was 50 years. Sex, race, and ethnicity were reported in 99%, 38%, and 26%, respectively. White and non-Hispanic participants were consistently overrepresented compared with the state-level census, while minority races and ethnicities tended to be underrepresented across nearly all neurosurgical subspecialties. Reporting of race and ethnicity increased significantly over time, but overall reporting rates remained low. Conclusions: Despite improvements in reporting over time, neurosurgical clinical trials demonstrate persistently low reporting of race/ethnicity and tend to have underrepresentation of racial and ethnic minority populations over all clinical trials and certain subspecialties. These findings highlight ongoing gaps in demographic transparency and inclusivity, supporting efforts toward more standardized reporting and broader participant representation in neurosurgical research. (Copyright © 2026 The Author(s). Published by Elsevier Inc. All rights reserved.) |
| Contributed Indexing: | Keywords: Clinical trials; Disparities; Neurosurgery |
| Entry Date(s): | Date Created: 20260406 Date Completed: 20260610 Latest Revision: 20260610 |
| Update Code: | 20260611 |
| DOI: | 10.1016/j.wneu.2026.124973 |
| PMID: | 41941958 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1878-8769 |
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| DOI: | 10.1016/j.wneu.2026.124973 |