Academic Journal
Multi-target bioactive M(II) pyridine-diamine complexes: synthesis, characterization, in vitro and in silico evaluation.
| Τίτλος: | Multi-target bioactive M(II) pyridine-diamine complexes: synthesis, characterization, in vitro and in silico evaluation. |
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| Συγγραφείς: | Nayab S; Department of Chemistry, Shaheed Benazir Bhutto University (SBBU), Sheringal Upper Dir 18050, Khyber Pakhtunkhwa, Islamic Republic of Pakistan., Subhan A; Department of Chemistry, Shaheed Benazir Bhutto University (SBBU), Sheringal Upper Dir 18050, Khyber Pakhtunkhwa, Islamic Republic of Pakistan., Khan SW; Department of Chemistry, Rawalpindi Women University, 6th Road, Satellite Town, Rawalpindi, Punjab, Islamic Republic of Pakistan., Kim D; KNU G-LAMP Research Center, KNU Institute of Basic Sciences, Kyungpook National University, 80 Daehakro, Bukgu, Daegu 41566, Republic of Korea., Yoon M; Department of Chemistry and Green-Nano Materials Research Center, Kyungpook National University, 80 Daehakro, Bukgu, Daegu 41566, Republic of Korea., Jeong SA; Department of Chemistry and Green-Nano Materials Research Center, Kyungpook National University, 80 Daehakro, Bukgu, Daegu 41566, Republic of Korea., Lee H; Department of Chemistry and Green-Nano Materials Research Center, Kyungpook National University, 80 Daehakro, Bukgu, Daegu 41566, Republic of Korea. Electronic address: hyosunlee@knu.ac.kr., Rashid HU; Center for Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, Pelotas, RS, Brazil; Department of Chemistry, Federal University of Juiz de Fora, Campus Universitário, Rua José Lourenço Kelmer - São Pedro, Juiz de Fora, MG, Brazil. Electronic address: haroongold@gmail.com. |
| Πηγή: | Bioorganic chemistry [Bioorg Chem] 2026 Jul 05; Vol. 175, pp. 109808. Date of Electronic Publication: 2026 Mar 30. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE |
| Imprint Name(s): | Publication: Amsterdam : Elsevier Original Publication: New York, London, Academic Press. |
| Ιατρικοί όροι (MeSH): | Urease*/antagonists & inhibitors , Urease*/metabolism , Pyridines*/chemistry , Pyridines*/pharmacology , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemical synthesis , Enzyme Inhibitors*/chemistry , Coordination Complexes*/pharmacology , Coordination Complexes*/chemistry , Coordination Complexes*/chemical synthesis , Antioxidants*/pharmacology , Antioxidants*/chemistry , Antioxidants*/chemical synthesis , Hypoglycemic Agents*/pharmacology , Hypoglycemic Agents*/chemical synthesis , Hypoglycemic Agents*/chemistry, Canavalia/enzymology ; Bacillus/enzymology ; Bacillus/drug effects ; Molecular Structure ; Structure-Activity Relationship ; Molecular Docking Simulation ; Dose-Response Relationship, Drug ; Humans ; Sporosarcina |
| Περίληψη: | In this study, we synthesized Co(II), Zn(II), and Cd(II) complexes based on a pyridine-derived ligand (N1,N1-diethyl-N2-(pyridin-2-ylmethyl)ethane-1,2-diamine, DEP-R). Single-crystal X-ray diffraction analysis confirmed that all complexes possessed distorted trigonal bipyramidal geometries. The complexes exhibited significant potential against both Jack bean (JB) and Bacillus pasteurii (BP) ureases. Notably, the [Cd(DEP-R)Br (Copyright © 2026 The Authors. Published by Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Antioxidant potential; Metallo-drug scaffold; Pyridine-derived ligand; Urease inhibition; X-ray structures; α-Amylase potential |
| Substance Nomenclature: | EC 3.5.1.5 (Urease) 0 (Pyridines) 0 (Enzyme Inhibitors) 0 (Coordination Complexes) 0 (Antioxidants) NH9L3PP67S (pyridine) 0 (Hypoglycemic Agents) |
| SCR Organism: | Sporosarcina pasteurii |
| Entry Date(s): | Date Created: 20260405 Date Completed: 20260714 Latest Revision: 20260714 |
| Update Code: | 20260715 |
| DOI: | 10.1016/j.bioorg.2026.109808 |
| PMID: | 41935403 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1090-2120 |
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| DOI: | 10.1016/j.bioorg.2026.109808 |