Academic Journal
Genome-wide association study reveals genetic loci associated with body shape related traits in Takifugu bimaculatus.
| Title: | Genome-wide association study reveals genetic loci associated with body shape related traits in Takifugu bimaculatus. |
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| Authors: | Zhao H; Tianjin Key Laboratory of Aqua-ecology and Aquaculture, College of Fisheries, Tianjin Agricultural University, Tianjin, 300384, China., Wang L; Tianjin Key Laboratory of Aqua-ecology and Aquaculture, College of Fisheries, Tianjin Agricultural University, Tianjin, 300384, China., Chang Y; Tianjin Key Laboratory of Aqua-ecology and Aquaculture, College of Fisheries, Tianjin Agricultural University, Tianjin, 300384, China; Key Laboratory of Smart Breeding (Co-construction by Ministry and Province, Ministry of Agriculture and Rural Affairs), Tianjin Agricultural University, Tianjin, 300384, China., Liang S; Tianjin Key Laboratory of Aqua-ecology and Aquaculture, College of Fisheries, Tianjin Agricultural University, Tianjin, 300384, China; Key Laboratory of Smart Breeding (Co-construction by Ministry and Province, Ministry of Agriculture and Rural Affairs), Tianjin Agricultural University, Tianjin, 300384, China., Liang J; Tianjin Key Laboratory of Aqua-ecology and Aquaculture, College of Fisheries, Tianjin Agricultural University, Tianjin, 300384, China; Key Laboratory of Smart Breeding (Co-construction by Ministry and Province, Ministry of Agriculture and Rural Affairs), Tianjin Agricultural University, Tianjin, 300384, China., Liu H; Tianjin Key Laboratory of Aqua-ecology and Aquaculture, College of Fisheries, Tianjin Agricultural University, Tianjin, 300384, China; Key Laboratory of Smart Breeding (Co-construction by Ministry and Province, Ministry of Agriculture and Rural Affairs), Tianjin Agricultural University, Tianjin, 300384, China., Song A; Tianjin Key Laboratory of Aqua-ecology and Aquaculture, College of Fisheries, Tianjin Agricultural University, Tianjin, 300384, China; Key Laboratory of Smart Breeding (Co-construction by Ministry and Province, Ministry of Agriculture and Rural Affairs), Tianjin Agricultural University, Tianjin, 300384, China., Li L; Fisheries Research Institute of Fujian, Xiamen, 361000, China., Guo Y; Tianjin Key Laboratory of Aqua-ecology and Aquaculture, College of Fisheries, Tianjin Agricultural University, Tianjin, 300384, China; Key Laboratory of Smart Breeding (Co-construction by Ministry and Province, Ministry of Agriculture and Rural Affairs), Tianjin Agricultural University, Tianjin, 300384, China. Electronic address: guoyongjun@tjau.edu.cn., Zhou Z; Tianjin Key Laboratory of Aqua-ecology and Aquaculture, College of Fisheries, Tianjin Agricultural University, Tianjin, 300384, China; Key Laboratory of Smart Breeding (Co-construction by Ministry and Province, Ministry of Agriculture and Rural Affairs), Tianjin Agricultural University, Tianjin, 300384, China. Electronic address: zhouzhix@tjau.edu.cn. |
| Source: | Comparative biochemistry and physiology. Part D, Genomics & proteomics [Comp Biochem Physiol Part D Genomics Proteomics] 2026 Sep; Vol. 59, pp. 101823. Date of Electronic Publication: 2026 Apr 01. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101270611 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-0407 (Electronic) Linking ISSN: 1744117X NLM ISO Abbreviation: Comp Biochem Physiol Part D Genomics Proteomics Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam : Elsevier, 2006- |
| MeSH Terms: | Takifugu*/genetics , Takifugu*/anatomy & histology , Takifugu*/growth & development , Body Size*/genetics , Genome-Wide Association Study* , Quantitative Trait Loci* , Genetic Loci*, Animals ; Polymorphism, Single Nucleotide |
| Abstract: | The twospot puffer (Takifugu bimaculatus) is a species of significant aquacultural value in East Asia, yet its production is constrained by slow growth rates and suboptimal body morphology. To advance genetic enhancement via marker-assisted selection, we conducted a genome-wide association study (GWAS) focusing on traits related to body shape. Utilizing a full-sib family comprising 167 individuals to reduce genetic variability, we employed whole-genome resequencing to identify 122,553 high-quality (SNPs) for association analysis. Our study identified 17 significant and suggestive SNP loci correlated with torso length (TL), body depth (BD), body width (BWI), head length (HL) and tail length (TAL). Functional annotation of surrounding genomic regions revealed 26 candidate genes associated with these traits, including lrp8, kank4 for TL; tfrc, dab1 for BD; pgm1, cp, rala, and cdh7 for BWI; gli3, sox17a, and zip12 for HL; myl9, smurf2 for TAL. These genes were implicated in skeletal development, cell migration, metabolism, and BMP/TGF-β signaling pathways. Our findings offered the first genetic insights into body shape in T. bimaculatus and provided valuable SNP markers for future genetic mapping of body shape related traits in multi-line famlies and marker-assisted selection breeding programs. (Copyright © 2026 Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: GWAS; Takifugu bimaculatus; body shape; whole-genome resequence |
| Entry Date(s): | Date Created: 20260404 Date Completed: 20260607 Latest Revision: 20260609 |
| Update Code: | 20260609 |
| DOI: | 10.1016/j.cbd.2026.101823 |
| PMID: | 41934866 |
| Database: | MEDLINE |
| ISSN: | 1878-0407 |
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| DOI: | 10.1016/j.cbd.2026.101823 |