Academic Journal
When viruses meet cystic fibrosis: Insights into host-pathogen dynamics.
| Τίτλος: | When viruses meet cystic fibrosis: Insights into host-pathogen dynamics. |
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| Συγγραφείς: | Lotti V; Microbiology Section, Department of Diagnostics and Public Health, University of Verona, Verona, Italy., Lagni A; Microbiology Section, Department of Diagnostics and Public Health, University of Verona, Verona, Italy., Diani E; Microbiology Section, Department of Diagnostics and Public Health, University of Verona, Verona, Italy., Palmisano A; Microbiology Section, Department of Diagnostics and Public Health, University of Verona, Verona, Italy., Cecchetto R; Microbiology Section, Department of Diagnostics and Public Health, University of Verona, Verona, Italy. Electronic address: riccardo.cecchetto@univr.it., Tonon E; UOC Microbiology and Virology, AOUI Verona, Verona, Italy., Sorio C; General Pathology Section, Department of Medicine, University of Verona, Verona, Italy., Gibellini D; Microbiology Section, Department of Diagnostics and Public Health, University of Verona, Verona, Italy; UOC Microbiology and Virology, AOUI Verona, Verona, Italy. |
| Πηγή: | Microbiological research [Microbiol Res] 2026 Jul; Vol. 308, pp. 128508. Date of Electronic Publication: 2026 Mar 29. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: G. Fischer Country of Publication: Germany NLM ID: 9437794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-0623 (Electronic) Linking ISSN: 09445013 NLM ISO Abbreviation: Microbiol Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Jena : G. Fischer, c1994- |
| Ιατρικοί όροι (MeSH): | Cystic Fibrosis*/virology , Cystic Fibrosis*/complications , Virus Diseases*/virology , Virus Diseases*/complications , Virus Diseases*/epidemiology , Respiratory Tract Infections*/virology , Host-Pathogen Interactions*, Viruses/pathogenicity ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Humans |
| Περίληψη: | Cystic fibrosis (CF), an autosomal-recessive genetic disorder, is caused by mutations in the CFTR gene, which encodes for a membrane anion channel expressed on multiple organs, with major impact on the airways. The impaired ion transport leads to thickened mucus secretions, which in turn can cause pancreatic insufficiency, sinusitis, infertility and, particularly, chronic pulmonary infections. While bacterial colonization of the airways has been extensively studied, increasing evidence highlights the significant, yet underappreciated, role of respiratory viruses in exacerbating lung disease in people with CF (pwCF). This review provides a comprehensive overview of the pathogenesis, epidemiology, and clinical impact of key respiratory viruses, including respiratory syncytial virus (RSV), human rhinovirus (HRV), influenza viruses, parainfluenza viruses, coronaviruses, and emerging pathogens such as human bocavirus, as well as relevant non-respiratory viruses, such as Cytomegalovirus (CMV), Epstein-Barr virus (EBV) and hepatitis viruses. Viral infections in pwCF are associated, particularly in pediatric patients, with increased respiratory symptoms, higher hospitalization rate and long-term decline in lung function. Despite a similar incidence of viral infections to non-CF individuals, pwCF often exhibit more severe clinical outcomes, except for SARS-CoV-2 infection, which shows an incidence and severity unexpectedly attenuated in this cohort. Moreover, while CFTR modulators have dramatically improved clinical outcomes in pwCF, their effects on antiviral immunity remain poorly understood and are an area of active investigation. Elucidating virus-host interactions and the impact of CFTR restoration in this context is essential for optimizing preventive and therapeutic strategies against viral infections in CF. (Copyright © 2026 The Authors. Published by Elsevier GmbH.. All rights reserved.) |
| Competing Interests: | Declaration of Competing Interest The authors declare no conflict of interest. |
| Contributed Indexing: | Keywords: Airway; Bacteria; CFTR; Cystic fibrosis; Respiratory infections; Viral infections |
| Substance Nomenclature: | 126880-72-6 (Cystic Fibrosis Transmembrane Conductance Regulator) |
| Entry Date(s): | Date Created: 20260403 Date Completed: 20260714 Latest Revision: 20260714 |
| Update Code: | 20260714 |
| DOI: | 10.1016/j.micres.2026.128508 |
| PMID: | 41930828 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1618-0623 |
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| DOI: | 10.1016/j.micres.2026.128508 |