Academic Journal
A Rare Case of Conjunctival Pseudoglandular Hyperplasia Identified During Mohs Micrographic Surgery of an Infraorbital Basal Cell Carcinoma.
| Τίτλος: | A Rare Case of Conjunctival Pseudoglandular Hyperplasia Identified During Mohs Micrographic Surgery of an Infraorbital Basal Cell Carcinoma. |
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| Συγγραφείς: | Spence S; Saint Louis University School of Medicine, St. Louis, Missouri, USA., Isaq N; Department of Dermatology, Micrographic Dermatologic Surgery, Sisters of Saint Mary (SSM) Saint Louis University Hospital, St. Louis, Missouri, USA., Behshad R; Department of Dermatology, Micrographic Dermatologic Surgery, Sisters of Saint Mary (SSM) Saint Louis University Hospital, St. Louis, Missouri, USA., Smith K; Department of Dermatology, Sisters of Saint Mary (SSM) Saint Louis University Hospital, St. Louis, Missouri, USA. |
| Πηγή: | Journal of cutaneous pathology [J Cutan Pathol] 2026 Aug; Vol. 53 (8), pp. 705-708. Date of Electronic Publication: 2026 Apr 01. |
| Τύπος έκδοσης: | Case Reports; Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Wiley Country of Publication: United States NLM ID: 0425124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0560 (Electronic) Linking ISSN: 03036987 NLM ISO Abbreviation: J Cutan Pathol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Malden, MA : Wiley Original Publication: Copenhagen, Blackwell Munksgaard. |
| Ιατρικοί όροι (MeSH): | Basal Cell Carcinoma*/pathology , Basal Cell Carcinoma*/surgery , Mohs Surgery*/methods , Skin Neoplasms*/pathology , Skin Neoplasms*/surgery , Conjunctiva*/pathology, Hyperplasia/pathology ; Humans ; Male ; Adult |
| Περίληψη: | A 38-year-old white male presented for Mohs Micrographic Surgery (MMS) consultation with a biopsy proven basal cell carcinoma (BCC) on the right infraorbital cheek encroaching upon the lower eyelid. During MMS, glandular proliferation and goblet cell hyperplasia were visualized on histologic sections, raising concern for an adnexal or mucinous carcinoma. Following referral for expert dermatopathological consultation, a final diagnosis of pseudoglandular hyperplasia of the conjunctiva (PHC) in the setting of chronic conjunctivitis was made, likely having developed in response to longstanding irritation from the nearby BCC. This case represents only the sixth reported case of PHC in the literature and the first identified incidentally during MMS of an adjacent cutaneous neoplasm. PHC is an uncommon, benign reactive proliferation characterized by invagination of the conjunctival epithelium into the stroma, forming gland-like structures. Due to its histological resemblance to invasive neoplasms, such as mucoepidermoid carcinoma, PHC poses a significant diagnostic and clinical conundrum. Only a handful of cases of PHC have been described and a diagnostic framework has yet to be sufficiently established. This report highlights the importance of increasing the awareness of this benign phenomenon and defining its histologic features to distinguish it from resemblant malignancies and avoid unnecessary surgery. (© 2026 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.) |
| References: | T. Milman, “Pathology of Conjunctiva,” Ento Key (2016), accessed September 1, 2025, https://entokey.com/pathology‐of‐conjunctiva/. C. L. Shumway, “Anatomy, Head and Neck, Eye Conjunctiva,” StatPearls [Internet] (2023), accessed September 1, 2025, https://www.ncbi.nlm.nih.gov/books/NBK519502/. S. Kawabata, Y. Yoshikawa, and Y. Kurisu, “Conjunctival Epithelial Hyperplasia in a Patient With a Nodular Lesion in the Palpebral Conjunctiva: A Case Report,” Jurnal Ekonomi Indonesia 10, no. 3 (2022): 24, https://doi.org/10.52813/jei.v10i3. S. Ben Tekaya, S. Graja, M. Rekik, et al., “Pseudoglandular Hyperplasia of the Conjunctiva: A Rare Entity,” Journal Français D'ophtalmologie 48, no. 1 (2025): 104347, https://doi.org/10.1016/j.jfo.2024.104347. C. E. Margo and H. E. Grossniklaus, “Pseudoadenomatous Hyperplasia of the Conjunctiva,” Ophthalmology 108, no. 1 (2001): 135–138, https://doi.org/10.1016/s0161‐6420(00)00501‐7. H. E. Grossniklaus, C. G. Eberhart, and T. T. Kivela, WHO Classification of Tumours of the Eye (World Health Organization, 2019). N. C. Charles and R. N. Palu, “Orbital Extension of Conjunctival Pseudoadenomatous Hyperplasia,” Ophthalmic Plastic and Reconstructive Surgery 34, no. 5 (2018): e153–e154, https://doi.org/10.1097/iop.0000000000001171. |
| Contributed Indexing: | Keywords: Mohs Micrographic Surgery; basal cell carcinoma; pseudoglands of henle; pseudoglandular hyperplasia of the conjunctiva; reactive conjunctival hyperplasia |
| Entry Date(s): | Date Created: 20260402 Date Completed: 20260708 Latest Revision: 20260708 |
| Update Code: | 20260708 |
| DOI: | 10.1111/cup.70102 |
| PMID: | 41923368 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1600-0560 |
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| DOI: | 10.1111/cup.70102 |