Academic Journal
Treatment of cartilage injury using a novel plug-type scaffold immersed in hyaluronic acid.
| Τίτλος: | Treatment of cartilage injury using a novel plug-type scaffold immersed in hyaluronic acid. |
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| Συγγραφείς: | Hirota C; Department of Orthopedic Surgery, Osaka Medical and Pharmaceutical University, Takatsuki City, Osaka, Japan., Ikeda K; Department of Orthopedic Surgery, Osaka Medical and Pharmaceutical University, Takatsuki City, Osaka, Japan., Ishitani T; Department of Orthopedic Surgery, Osaka Medical and Pharmaceutical University, Takatsuki City, Osaka, Japan., Iwata T; Department of Orthopedic Surgery, Osaka Medical and Pharmaceutical University, Takatsuki City, Osaka, Japan., Ito E; Department of Orthopedic Surgery, Osaka Medical and Pharmaceutical University, Takatsuki City, Osaka, Japan., Sezaki S; Department of Orthopedic Surgery, Osaka Medical and Pharmaceutical University, Takatsuki City, Osaka, Japan.; Product Development and Research Team, GUNZE Medical Limited, Osaka, Japan., Morita D; Product Development and Research Team, GUNZE Medical Limited, Osaka, Japan., Okamoto Y; Department of Orthopedic Surgery, Osaka Medical and Pharmaceutical University, Takatsuki City, Osaka, Japan., Wakama H; Department of Orthopedic Surgery, Osaka Medical and Pharmaceutical University, Takatsuki City, Osaka, Japan., Otsuki S; Department of Orthopedic Surgery, Osaka Medical and Pharmaceutical University, Takatsuki City, Osaka, Japan. |
| Πηγή: | Journal of biomaterials applications [J Biomater Appl] 2026 Oct; Vol. 41 (4), pp. 519-527. Date of Electronic Publication: 2026 Mar 31. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Sage Publications Country of Publication: England NLM ID: 8813912 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-8022 (Electronic) Linking ISSN: 08853282 NLM ISO Abbreviation: J Biomater Appl Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2002- : London : Sage Publications Original Publication: Lancaster, PA : Technomic Pub. Co., Inc., [c1986- |
| Ιατρικοί όροι (MeSH): | Hyaluronic Acid*/chemistry , Hyaluronic Acid*/administration & dosage , Hyaluronic Acid*/therapeutic use , Tissue Scaffolds*/chemistry , Cartilage, Articular*/injuries, Polyesters/chemistry ; Polyglycolic Acid/chemistry ; Animals ; Swine ; Chondrocytes ; Regeneration |
| Περίληψη: | The osteochondral autograft transfer system has demonstrated potential for hyaline cartilage restoration; however, donor-site morbidity remains a considerable challenge. Therefore, we aimed to develop an innovative plug-type cartilage scaffold using polyglycolic acid (PGA) and poly (L-lactide-co-ε-caprolactone) [P (LA/CL)], and evaluate its effectiveness in a cartilage injury model. We fabricated cartilage plugs by wrapping PGA felt with P (LA/CL) sutures combined with a P (LA/CL) sponge, and implanted the plugs into porcine knee cartilage defects to investigate their effectiveness with and without hyaluronic acid (HA). In addition to HA infiltration and release kinetics plug assessments, we performed a histological assessment of cartilage repair. The cartilage plug scaffold exhibited drug delivery capabilities, achieving 150% HA infiltration within 30 min and sustained HA release effects for over 24 h. The cartilage plugs immersed in HA exhibited a smooth surface and rich glycosaminoglycan cartilage regeneration, indicating that HA in the scaffold may enhance chondrocyte migration and the extracellular matrix. The PGA-based cartilage plug scaffold reinforced with P (LA/CL) and immersed in HA facilitated effective hyaline cartilage repair, providing a new therapeutic option for less invasive cartilage treatment. |
| Competing Interests: | Declaration of conflicting interestsThe authors declare no potential conflicts of interest with respect to the research, authorship, or publication of this article. |
| Contributed Indexing: | Keywords: cartilage regeneration; hyaluronic acid; polyglycolic acid; porcine defect model; scaffold |
| Substance Nomenclature: | 9004-61-9 (Hyaluronic Acid) 0 (Polyesters) 26009-03-0 (Polyglycolic Acid) 70524-20-8 (lactide-caprolactone copolymer) |
| Entry Date(s): | Date Created: 20260331 Date Completed: 20260910 Latest Revision: 20260910 |
| Update Code: | 20260910 |
| DOI: | 10.1177/08853282261440933 |
| PMID: | 41914207 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1530-8022 |
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| DOI: | 10.1177/08853282261440933 |