Academic Journal
Epigenetic remodeling induced by fatty acids: Chromatin modifications and cellular senescence during lipid overload.
| Τίτλος: | Epigenetic remodeling induced by fatty acids: Chromatin modifications and cellular senescence during lipid overload. |
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| Συγγραφείς: | Ávila-Galicia KE; Posgrado en Biología Experimental, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana Unidad-Iztapalapa (UAM-I), Ciudad de México, Mexico; Laboratorio de Bioenergética y Envejecimiento Celular, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana Unidad-Iztapalapa (UAM-I), Ciudad de México, Mexico., Alarcón-Aguilar A; Laboratorio de Bioenergética y Envejecimiento Celular, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana Unidad-Iztapalapa (UAM-I), Ciudad de México, Mexico., Soto-Reyes E; Departamento de Ciencias Naturales, Universidad Autónoma Metropolitana-Cuajimalpa (UAM-C), Ciudad de México, Mexico., Königsberg M; Laboratorio de Bioenergética y Envejecimiento Celular, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana Unidad-Iztapalapa (UAM-I), Ciudad de México, Mexico. Electronic address: mkf@xanum.uam.mx. |
| Πηγή: | Ageing research reviews [Ageing Res Rev] 2026 Jun; Vol. 118, pp. 103115. Date of Electronic Publication: 2026 Mar 27. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Country of Publication: England NLM ID: 101128963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9649 (Electronic) Linking ISSN: 15681637 NLM ISO Abbreviation: Ageing Res Rev Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Oxford, UK : Elsevier Science, c2002- |
| Ιατρικοί όροι (MeSH): | Cellular Senescence*/physiology , Cellular Senescence*/genetics , Epigenesis, Genetic*/physiology , Fatty Acids*/metabolism , Chromatin Assembly and Disassembly*/physiology , Aging*/genetics , Aging*/metabolism , Chromatin*/metabolism, Obesity/metabolism ; Obesity/genetics ; Humans ; Animals |
| Περίληψη: | Cellular senescence is a stable cell state sustained by specific gene expression programs that are established and maintained through dynamic changes in chromatin organization. Importantly, these programs are highly dependent on the nature of the senescence-inducing stimulus. In recent years, lipid overload has emerged as a relevant metabolic stress capable of inducing senescence across multiple cell types and tissues, particularly in the context of obesity and high-fat diets. Accumulating evidence indicates that this process is tightly linked to metabolic rewiring, which directly impacts chromatin-modifying enzymes and chromatin remodelers through fluctuations in key metabolites such as acetyl-CoA, NAD⁺, and α-ketoglutarate. In this review, we integrate current evidence on how fatty acid-driven metabolic alterations reshape chromatin dynamics to promote and stabilize cellular senescence. (Copyright © 2026 The Authors. Published by Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper |
| Contributed Indexing: | Keywords: Aging; Cellular senescence; Chromatin; Diet; Epigenomics; Fatty acids; High-fat; Obesity |
| Substance Nomenclature: | 0 (Fatty Acids) 0 (Chromatin) |
| Entry Date(s): | Date Created: 20260329 Date Completed: 20260714 Latest Revision: 20260714 |
| Update Code: | 20260714 |
| DOI: | 10.1016/j.arr.2026.103115 |
| PMID: | 41905425 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1872-9649 |
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| DOI: | 10.1016/j.arr.2026.103115 |