Academic Journal
The association between attempted suicide and ADHD in adolescents: A large-scale population-based study.
| Τίτλος: | The association between attempted suicide and ADHD in adolescents: A large-scale population-based study. |
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| Συγγραφείς: | Rotariu Z; Gray Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel. Electronic address: ziv.rotario@mail.huji.ac.il., Shkalim Zemer V; Gray Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel; Dan-Petach-Tikva District, Clalit Health Services, Israel., Medvejer S; Gray Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel., Hoshen M; Bioinformatics Department, Jerusalem College of Technology, Jerusalem, Israel., Soloveichik Jarus Y; Technion Israel Institute of Technology, Israel., Menkes-Caspi N; Geha Mental Health Center, Petah Tikva, Israel., Weizman A; Gray Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel; Geha Mental Health Center, Petah Tikva, Israel; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel., Manor I; Gray Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel; Dan-Petach-Tikva District, Clalit Health Services, Israel; Geha Mental Health Center, Petah Tikva, Israel. |
| Πηγή: | Journal of affective disorders [J Affect Disord] 2026 Aug 01; Vol. 406, pp. 121686. Date of Electronic Publication: 2026 Mar 25. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| Ιατρικοί όροι (MeSH): | Attention Deficit Disorder with Hyperactivity*/epidemiology , Attention Deficit Disorder with Hyperactivity*/psychology , Suicide, Attempted*/statistics & numerical data , Suicide, Attempted*/psychology, Major Depressive Disorder/epidemiology ; Major Depressive Disorder/psychology ; Personality Disorders/epidemiology ; Personality Disorders/psychology ; Anxiety Disorders/epidemiology ; Humans ; Female ; Adolescent ; Male ; Retrospective Studies ; Comorbidity ; Case-Control Studies ; Risk Factors ; Child |
| Περίληψη: | Background: Suicide is the second leading cause of death among adolescents. Although suicide attempts are most frequently associated with mood, sleep, and personality disorders, attention-deficit/hyperactivity disorder (ADHD) may also confer risk. We hypothesized that ADHD is independently associated with suicide attempts beyond the effects of psychiatric comorbidities. Methods: We conducted a retrospective, population-based case-control study using electronic medical records from Clalit Health Services (N = 1,652,752) among adolescents aged 12-18 years. The study group comprised 1763 adolescents who presented to emergency departments for attempted suicide between 2010 and 2022. Diagnoses were based on ICD-10 and DSM-5 criteria. Logistic regression analyses assessed associations between ADHD and attempted suicide while adjusting for comorbid psychiatric disorders. Results: Adolescents who attempted suicide exhibited a markedly higher female-to-male ratio (80%:20%) than the general population (51%:49%). Higher socioeconomic status among adolescents with ADHD was significantly associated with increased attempted suicide risk. Comorbidities, including major depressive disorder, anxiety, and personality disorders, were also linked to suicide attempts. Importantly, ADHD remained an independent risk factor for attempted suicide even after excluding significant psychiatric comorbidities (e.g., without depression: OR 2.12, 95% CI 1.91-2.35; without borderline personality disorder: OR 2.39, 95% CI 2.15-2.65). Conclusions: ADHD significantly increases the risk of suicide attempts in adolescents, independent of common psychiatric comorbidities. These findings underscore the need for targeted screening and prevention strategies in this high-risk population. (Copyright © 2026 The Authors. Published by Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The other authors have no conflicts or competing interests relevant to this article to disclose. |
| Contributed Indexing: | Keywords: Adolescents; Attempted suicide; Attention-deficit/hyperactivity disorder (ADHD); Population-based study; Psychiatric comorbidities; Suicide prevention |
| Entry Date(s): | Date Created: 20260327 Date Completed: 20260714 Latest Revision: 20260714 |
| Update Code: | 20260714 |
| DOI: | 10.1016/j.jad.2026.121686 |
| PMID: | 41895612 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1573-2517 |
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| DOI: | 10.1016/j.jad.2026.121686 |