Academic Journal
In vitro platforms for reconstructing skin-microbiome interactions.
| Τίτλος: | In vitro platforms for reconstructing skin-microbiome interactions. |
|---|---|
| Συγγραφείς: | Park J; Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea., Kim J; Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea., Cho S; Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea., Shin W; Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea; Graduate School of Engineering Biology, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea; Graduate School of Stem Cells and Regenerative Biology, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea. Electronic address: woojungshin@kaist.ac.kr. |
| Πηγή: | Trends in biotechnology [Trends Biotechnol] 2026 Oct; Vol. 44 (10), pp. 2926-2940. Date of Electronic Publication: 2026 Mar 25. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Publishers Country of Publication: England NLM ID: 8310903 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3096 (Electronic) Linking ISSN: 01677799 NLM ISO Abbreviation: Trends Biotechnol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Barking : Elsevier Science Publishers Original Publication: [Amsterdam, Netherlands : Elsevier Science Publishers B.V. (Biomedical Division), c1983- |
| Ιατρικοί όροι (MeSH): | Skin*/microbiology , Skin Microbiome*, Humans ; Animals ; Microphysiological Systems ; Coculture Techniques |
| Περίληψη: | The growing recognition of the skin microbiome in regulating the host's metabolic and immune functions has spurred the development of in vitro platforms designed to recapitulate their intricate interactions, aiding research into both skin-microbiome and microbe-microbe interactions within their distinct niches. Despite these efforts, challenges remain in dissecting skin-microbiome interactions, especially due to the absence of a standardized platform for the long-term coculture of bacterial and mammalian cells. In this review, we highlight the key components in modeling an in vitro skin ecosystem and discuss the therapeutic potential of skin commensals, including recent advances and applications for engineered live biotherapeutics targeting skin diseases, to underscore the translational value of in vitro skin-microbiome interaction studies. (Copyright © 2026 Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of interests The authors declare no competing interests. |
| Contributed Indexing: | Keywords: host–microbiome interactions; in vitro platforms; live biotherapeutics; skin microbiome; skin-on-a-chip; synthetic biology |
| Entry Date(s): | Date Created: 20260325 Date Completed: 20261007 Latest Revision: 20261007 |
| Update Code: | 20261008 |
| DOI: | 10.1016/j.tibtech.2026.02.006 |
| PMID: | 41881738 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1879-3096 |
|---|---|
| DOI: | 10.1016/j.tibtech.2026.02.006 |