Academic Journal
Natural Course of Neuropsychological Functions in Chronic Non-Surgical Hypoparathyroidism on Conventional Therapy: 12 Years of Follow-Up.
| Τίτλος: | Natural Course of Neuropsychological Functions in Chronic Non-Surgical Hypoparathyroidism on Conventional Therapy: 12 Years of Follow-Up. |
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| Συγγραφείς: | Namjoshi P; Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India., Seetharaman S; Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, India., Saha S; Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India., Kalaivani M; Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India., Tripathi M; Department of Neurology, All India Institute of Medical Sciences, New Delhi, India., Kandasamy D; Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India., Aggarwal S; Dr Sameer Aggarwal's Endocrine Centre, Rohtak, Haryana, India., Sagar R; Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, India., Goswami R; Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India. gosravinder@aiims.edu. |
| Πηγή: | Calcified tissue international [Calcif Tissue Int] 2026 Mar 24; Vol. 117 (1). Date of Electronic Publication: 2026 Mar 24. |
| Τύπος έκδοσης: | Journal Article; Observational Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer Verlag Country of Publication: United States NLM ID: 7905481 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0827 (Electronic) Linking ISSN: 0171967X NLM ISO Abbreviation: Calcif Tissue Int Subsets: MEDLINE |
| Imprint Name(s): | Publication: New York Ny : Springer Verlag Original Publication: Berlin, New York, Springer International. |
| Ιατρικοί όροι (MeSH): | Hypoparathyroidism*/psychology , Hypoparathyroidism*/complications, Cognition/physiology ; Humans ; Male ; Female ; Follow-Up Studies ; Middle Aged ; Adult ; Neuropsychological Tests ; Quality of Life ; Chronic Disease ; Cohort Studies |
| Περίληψη: | Purpose: Neuropsychological manifestations are common in chronic hypoparathyroidism (cHypoPT). Here, we report the change in cognitive and neuropsychiatric functions in cHypoPT during long-term follow-up. Design: Observational-cohort study. Methods: Fifty-four patients with non-surgical idiopathic cHypoPT (M: F = 24:30, age = 47.8 ± 14.0 years, duration of hypoparathyroidism = 24.5 ± 7.7 years), who were evaluated for cognitive, neuropsychiatric function, and quality of life in 2011-12, were re-evaluated in 2023-24 using the same battery of tests. Change in intracranial calcification was compared with previous computed tomography scans. Multivariable regression was used to assess association of change in cognitive and neuropsychiatric function with sex, age, body mass index (BMI), sites of intracranial calcification, and time weighted estimated glomerular filtration rate (eGFR), serum total calcium, phosphate, their product, and ratio. Results: The mean global cognitive dysfunction score increased during follow-up (4.04 ± 2.56 to 5.69 ± 2.10, p < 0.001). Motor speed and fine control, memory, trail-making test, Bender-Gestalt test, and quality of life showed significant deterioration. Deterioration in cognition was associated with increased age (p < 0.001). Neuropsychiatric assessment showed significant improvement in somatic concerns, anxiety, tension, and hostility. Male patient, increasing age, and higher BMI showed significant association with improvement in neuropsychiatric function. However, duration of illness and lower eGFR were associated with neuropsychiatric deterioration (p = 0.003 and 0.035). Changes in intracranial-calcification and biochemical control showed no significant association with cognitive and neuropsychiatric functions. Conclusions: Hypoparathyroid patients showed a significant decline in cognitive function during follow-up. However, neuropsychiatric function improved during follow-up, more so in males, in older individuals and in those with a higher BMI. Deteriorating cognition could affect the earning and compliance with treatment. Further studies assessing the role of behavioral/drug therapy would be helpful in cHypoPT. (© 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
| Competing Interests: | Declarations. Conflict of interest: On behalf of all authors, the corresponding authors state that there is no conflict of interest. |
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| Grant Information: | R.11012/22/2023-GIA/HR Department of Health Research, Indian council of medical Sciences, India (IN) |
| Contributed Indexing: | Keywords: Chronic hypoparathyroidism; Intracranial calcification; Long-term outcome; Neuropsychiatric and cognitive function |
| Entry Date(s): | Date Created: 20260324 Date Completed: 20260713 Latest Revision: 20260807 |
| Update Code: | 20260807 |
| DOI: | 10.1007/s00223-026-01507-9 |
| PMID: | 41874653 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1432-0827 |
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| DOI: | 10.1007/s00223-026-01507-9 |