Academic Journal
Atherosclerosis burden across subtypes of steatotic liver disease: a European cohort analysis.
| Τίτλος: | Atherosclerosis burden across subtypes of steatotic liver disease: a European cohort analysis. |
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| Συγγραφείς: | Bauer J; First Department of Internal Medicine, University Hospital Salzburg, Paracelsus Medical University, Müllner Hauptstraße 48, Salzburg, 5020, Austria. Electronic address: jo.bauer@salk.at., Gensluckner S; First Department of Internal Medicine, University Hospital Salzburg, Paracelsus Medical University, Müllner Hauptstraße 48, Salzburg, 5020, Austria. Electronic address: s.gensluckner@salk.at., Eberhardt J; First Department of Internal Medicine, University Hospital Salzburg, Paracelsus Medical University, Müllner Hauptstraße 48, Salzburg, 5020, Austria. Electronic address: ju.eberhardt@salk.at., Akhgar A; First Department of Internal Medicine, University Hospital Salzburg, Paracelsus Medical University, Müllner Hauptstraße 48, Salzburg, 5020, Austria. Electronic address: a.akhgar@salk.at., Datz C; Department of Internal Medicine, General Hospital Oberndorf, Teaching hospital of the Paracelsus Medical University, Paracelsusstraße 37, Oberndorf bei Salzburg, 5110, Austria. Electronic address: C.Datz@kh-oberndorf.at., Iglseder B; Department of Geriatrics, Christian Doppler University Hospital, Paracelsus Medical University Salzburg, Ignaz-Harrer-Straße 79, Salzburg, 5020, Austria. Electronic address: b.iglseder@salk.at., Langthaler P; Department of Neurology, Neurocritical Care and Neurorehabilitation, Christian Doppler University Hospital, Paracelsus Medical University, Ignaz-Harrer-Straße 79, Salzburg, 5020, Austria. Electronic address: p.langthaler@salk.at., Trinka E; Department of Neurology, Neurocritical Care and Neurorehabilitation, Christian Doppler University Hospital, Paracelsus Medical University, Ignaz-Harrer-Straße 79, Salzburg, 5020, Austria; Neuroscience Institute, Christian Doppler University Hospital, Paracelsus Medical University, Ignaz-Harrer-Straße 79, Salzburg, 5020, Austria; Karl Landsteiner Institute for Clinical Neurosciences, Ignaz-Harrer-Straße 79, Salzburg, 5020, Austria. Electronic address: e.trinka@salk.at., Ausserwinkler M; Elisabethinen Hospital Klagenfurt, Viktringer Ring 28, Klagenfurt am Wörthersee, 9020, Austria. Electronic address: mathias.ausserwinkler@ekh.at., Semmler G; Third Department of Internal Medicine, Medical University of Vienna, Währinger Gürtel 18-20, Vienna, 1090, Austria. Electronic address: georg.semmler@meduniwien.ac.at., Paulweber B; First Department of Internal Medicine, University Hospital Salzburg, Paracelsus Medical University, Müllner Hauptstraße 48, Salzburg, 5020, Austria. Electronic address: b.paulweber@gmail.com., Aigner E; First Department of Internal Medicine, University Hospital Salzburg, Paracelsus Medical University, Müllner Hauptstraße 48, Salzburg, 5020, Austria. Electronic address: e.aigner@salk.at., Wernly B; First Department of Internal Medicine, University Hospital Salzburg, Paracelsus Medical University, Müllner Hauptstraße 48, Salzburg, 5020, Austria. Electronic address: b.wernly@salk.at. |
| Πηγή: | Nutrition, metabolism, and cardiovascular diseases : NMCD [Nutr Metab Cardiovasc Dis] 2026 Jun; Vol. 36 (6), pp. 104618. Date of Electronic Publication: 2026 Feb 11. |
| Τύπος έκδοσης: | Journal Article; Comparative Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9111474 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1590-3729 (Electronic) Linking ISSN: 09394753 NLM ISO Abbreviation: Nutr Metab Cardiovasc Dis Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2005- : Amsterdam : Elsevier Original Publication: [Heidelberg] : Springer International, c1991- |
| Ιατρικοί όροι (MeSH): | Carotid Artery Diseases*/epidemiology , Carotid Artery Diseases*/diagnostic imaging , Coronary Artery Disease*/epidemiology , Coronary Artery Disease*/diagnostic imaging , Coronary Artery Disease*/genetics , Vascular Calcification*/epidemiology , Vascular Calcification*/diagnostic imaging , Fatty Liver, Alcoholic*/epidemiology , Fatty Liver, Alcoholic*/diagnosis , Fatty Liver*/epidemiology , Fatty Liver*/diagnosis , Non-alcoholic Fatty Liver Disease*/epidemiology , Non-alcoholic Fatty Liver Disease*/diagnosis, Europe/epidemiology ; Coronary Angiography/methods ; Humans ; Cross-Sectional Studies ; Female ; Risk Factors ; Male ; Prevalence ; Plaque, Atherosclerotic ; Middle Aged ; Ultrasonography, Carotid Arteries ; Aged ; Risk Assessment ; Genetic Risk Score ; Computed Tomography Angiography ; Adult |
| Περίληψη: | Background and Aim: Steatotic liver disease (SLD) affects over 30% of adults and is classified into metabolic dysfunction-associated (MASLD), alcohol-related (ALD), and metabolic dysfunction and alcohol-associated (MetALD) subtypes. Cardiovascular disease is the leading cause of death in SLD, yet the differential atherosclerotic risk across subtypes remains uncertain. Methods and Results: We conducted a cross-sectional analysis of 7820 participants from the population-based Paracelsus 10,000 cohort. SLD was defined by the Fatty Liver Index according to international consensus criteria. Atherosclerosis was assessed by carotid ultrasonography (n = 7820), coronary artery calcium (CAC) scoring by computed tomography (n = 1434), and polygenic risk scores (PGS, n = 1652). Primary outcomes were carotid plaque presence and CAC burden (Agatston score). Multivariable logistic regression adjusted for age, sex, and SCORE2 cardiovascular risk. We identified 5448 controls (69.7%), 2098 MASLD (26.8%), 201 ALD (2.6%), and 73 MetALD (0.9%). Carotid plaque prevalence increased stepwise: 30% in controls, 47% in MASLD, 53% in MetALD, and 62% in ALD (p<0.001). High-risk CAC (Agatston >300) was present in 4% of controls, 7% of MASLD, and 18% of both MetALD and ALD (p<0.001). Unadjusted odds ratios for plaque were 2.10 (95% CI, 1.89-2.33) for MASLD, 2.69 (1.69-4.28) for MetALD, and 3.86 (2.89-5.16) for ALD. After SCORE2 adjustment, associations attenuated and lost statistical significance. CAD-PGS differed modestly across subtypes (p=0.019) and inclusion further attenuated associations. Conclusions: All SLD subtypes were associated with increased atherosclerotic burden, with ALD showing the highest risk. Associations were attenuated after adjustment for established cardiovascular risk factors, indicating shared cardiometabolic rather than liver-specific pathways. (Copyright © 2026 The Authors. Published by Elsevier B.V. All rights reserved.) |
| Contributed Indexing: | Keywords: Alcohol-related liver disease; Atherosclerosis; Cardiovascular risk; Metabolic dysfunction and alcohol-associated liver disease; Metabolic dysfunction-associated steatotic liver disease; Steatotic liver disease |
| Entry Date(s): | Date Created: 20260319 Date Completed: 20260711 Latest Revision: 20260711 |
| Update Code: | 20260711 |
| DOI: | 10.1016/j.numecd.2026.104618 |
| PMID: | 41856834 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1590-3729 |
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| DOI: | 10.1016/j.numecd.2026.104618 |