Academic Journal
Epigenetic dynamics of cellular senescence: From mechanistic insights to precision senotherapy.
| Τίτλος: | Epigenetic dynamics of cellular senescence: From mechanistic insights to precision senotherapy. |
|---|---|
| Συγγραφείς: | Hu X; Department of Nephrology, Institute of Kidney Diseases, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.; West China School of Medicine, Sichuan University, Chengdu, Sichuan 610041, China., Lai W; Department of Nephrology, The Key Laboratory for the Prevention and Treatment of Kidney Disease of Chongqing, Chongqing Clinical Research Center of Kidney and Urology Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing 400037, China., Liu M; Department of Anesthesiology, Air Force Hospital of Western Theater Command, PLA, Chengdu, Sichuan 610011, China., Wang B; Department of Nephrology, Institute of Kidney Diseases, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.; West China School of Medicine, Sichuan University, Chengdu, Sichuan 610041, China. |
| Πηγή: | Chinese medical journal [Chin Med J (Engl)] 2026 Jul 05; Vol. 139 (13), pp. 1913-1942. Date of Electronic Publication: 2026 Mar 17. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Chinese Medical Association ; produced by Wolters Kluwer Country of Publication: China NLM ID: 7513795 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2542-5641 (Electronic) Linking ISSN: 03666999 NLM ISO Abbreviation: Chin Med J (Engl) Subsets: MEDLINE |
| Imprint Name(s): | Publication: <2015- > : Beijing : Chinese Medical Association ; produced by Wolters Kluwer Original Publication: Peking, Chinese Medical Assn. |
| Ιατρικοί όροι (MeSH): | Cellular Senescence*/genetics , Cellular Senescence*/physiology , Epigenesis, Genetic*/genetics , Senotherapeutics*, DNA Methylation/genetics ; Humans ; Animals |
| Περίληψη: | Abstract: Cellular senescence functions as a pivotal stress response with dual roles; it serves as a barrier against early tumorigenesis while paradoxically driving late-stage tumor progression and the pathogenesis of many other age-related diseases, including cardiovascular, neurodegenerative, metabolic, and fibrotic disorders. This review comprehensively elucidates how the senescent phenotype is orchestrated by a dynamic epigenetic landscape. We detail how dysregulation in chromatin remodeling (e.g., heterochromatin loss), histone modifications, DNA methylation, and the epitranscriptome rewrites genome architecture to govern the initiation and maintenance of the senescent phenotype within these specific disease contexts. Crucially, we highlight the profound heterogeneity of senescence across different pathologies, contrasting its detrimental role in driving tissue degeneration in organs like the lung and kidney against its context-dependent beneficial effects, such as limiting fibrosis in the liver. Furthermore, we evaluate the translational potential of epigenetic drugs-categorized by targets such as DNA methyltransferases (DNMTs), histone methyltransferases (HMTs), and histone deacetylases (HDACs)-as dual-purpose therapeutics. Unlike genetic mutations, epigenetic alterations are reversible. We discuss strategies to either enforce senescence barriers for cancer suppression (pro-senescence) or reverse epigenetic aging signatures for tissue rejuvenation (anti-senescence). This review proposes a roadmap for leveraging epigenetic plasticity, offering a precision medicine approach to target specific senescent cell populations and extend health span. (Copyright © 2026 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.) |
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| Contributed Indexing: | Keywords: Age-related diseases; Cellular senescence; Epigenomics; Senolytics; Senomorphics |
| Substance Nomenclature: | 0 (Senotherapeutics) |
| Entry Date(s): | Date Created: 20260318 Date Completed: 20260705 Latest Revision: 20260726 |
| Update Code: | 20260726 |
| PubMed Central ID: | PMC13331420 |
| DOI: | 10.1097/CM9.0000000000004042 |
| PMID: | 41850873 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2542-5641 |
|---|---|
| DOI: | 10.1097/CM9.0000000000004042 |