Academic Journal
State-of-the-art on absorption mechanisms and factors affecting the bioavailability of preformed vitamin A.
| Τίτλος: | State-of-the-art on absorption mechanisms and factors affecting the bioavailability of preformed vitamin A. |
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| Συγγραφείς: | Borel P; C2VN, Aix Marseille Univ, INRAE, INSERM, Marseille, France. Electronic address: patrick.borel@univ-amu.fr., Le HD; Nestlé Product Technology Center for Nutrition, Konolfingen, Switzerland., Sabatier M; Nestlé Institute of Health Sciences, Nestlé Research, Société des Produits Nestlé S.A., Vers-Chez-Les-Blanc, Lausanne, Switzerland. |
| Πηγή: | Progress in lipid research [Prog Lipid Res] 2026 Jun; Vol. 101, pp. 101382. Date of Electronic Publication: 2026 Mar 17. |
| Τύπος έκδοσης: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Pergamon Country of Publication: England NLM ID: 7900832 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2194 (Electronic) Linking ISSN: 01637827 NLM ISO Abbreviation: Prog Lipid Res Subsets: MEDLINE |
| Imprint Name(s): | Publication: Oxford : Pergamon Original Publication: Oxford; Elmsford, N. Y., Pergamon Press. |
| Ιατρικοί όροι (MeSH): | Vitamin A*/metabolism , Vitamin A*/pharmacokinetics , Intestinal Absorption*, Vitamin A Deficiency/metabolism ; Humans ; Biological Availability ; Animals |
| Περίληψη: | Vitamin A deficiency remains a major health issue in many countries. Two types of vitamin A are naturally present in our diet, provitamin A carotenoids from plant sources and preformed vitamin A, mainly retinyl esters and retinol, found in animal products, fortified foods and supplements. The objective was to review current knowledge and gaps in understanding the mechanism and factors influencing preformed vitamin A bioavailability. The results show that the fate of retinyl esters in the intestine is well described, but that of retinol deserves further investigation. Preformed vitamin A present in liver, oil, sugar, and milk is well absorbed (70 to 99%), but data for other important matrices like eggs and fortified flours is lacking. The impact of the type and quantity of dietary lipids is unclear, especially whether low levels in a meal would be sufficient for optimal vitamin A absorption. Further research is needed to evaluate the effect of plant proteins and dietary fibers for which results are conflicting. The impact of host related factors like age is limited, and largely unknown for gender and genetic/epigenetic factors. It is well established that inflammation and other metabolic disorders affect vitamin A status, yet further study could help to distinguish absorption issues from other metabolic processes. An interesting avenue is the possible role of microbiota and probiotics on vitamin A absorption, as it could represent a complementary approach to food fortification. Further clinical research should prioritize the use of tracers to better quantify absorption under various nutritional conditions. (Copyright © 2024. Published by Elsevier Ltd.) |
| Competing Interests: | Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Magalie Sabatier and Le Hoang Du reports a relationship with Nestlé Research & Development that includes: employment. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Fortificants; Retinol; Retinyl acetate; Retinyl esters; Retinyl palmitate; Supplements |
| Substance Nomenclature: | 11103-57-4 (Vitamin A) |
| Entry Date(s): | Date Created: 20260318 Date Completed: 20260608 Latest Revision: 20260614 |
| Update Code: | 20260615 |
| DOI: | 10.1016/j.plipres.2026.101382 |
| PMID: | 41850408 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1873-2194 |
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| DOI: | 10.1016/j.plipres.2026.101382 |