Academic Journal
Duration-Dependent Efficacy and Clinical Safety of Repeated Low-Level Red-Light Therapy for Paediatric Myopia: A Systematic Review and Meta-Analysis.
| Τίτλος: | Duration-Dependent Efficacy and Clinical Safety of Repeated Low-Level Red-Light Therapy for Paediatric Myopia: A Systematic Review and Meta-Analysis. |
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| Συγγραφείς: | Lin LY; School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan., Hsu CH; School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Su H; School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Sun JW; School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Wu JS; School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Jeng WJ; School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Tsai CH; Department of Ophthalmology, Taipei Medical University Hospital, Taipei, Taiwan., Yuliani FS; Department of Pharmacology and Therapy, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia., Lin SH; School of Nutrition, College of Nutrition, Taipei Medical University, Taipei, Taiwan.; School of Food Safety, College of Nutrition, Taipei Medical University, Taipei, Taiwan. |
| Πηγή: | Clinical & experimental ophthalmology [Clin Exp Ophthalmol] 2026 Jul; Vol. 54 (5), pp. 630-652. Date of Electronic Publication: 2026 Mar 18. |
| Τύπος έκδοσης: | Journal Article; Systematic Review; Meta-Analysis |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Wiley-Blackwell Pub. Asia Country of Publication: Australia NLM ID: 100896531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1442-9071 (Electronic) Linking ISSN: 14426404 NLM ISO Abbreviation: Clin Exp Ophthalmol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Carlton, Vic. : Wiley-Blackwell Pub. Asia Original Publication: Carlton, Vic. : Blackwell Science Asia, c2000- |
| Ιατρικοί όροι (MeSH): | Low-Level Light Therapy*/methods , Myopia*/physiopathology , Myopia*/therapy , Refraction, Ocular*/physiology , Red Light*, Visual Acuity/physiology ; Child ; Humans ; Axial Length, Eye ; Randomized Controlled Trials as Topic ; Treatment Outcome |
| Περίληψη: | Background: Repeated low-level red-light (RLRL) therapy is a novel, non-invasive intervention for controlling paediatric myopia progression. Despite increasing clinical use, questions remain regarding the magnitude, durability, and safety of treatment effects. This study evaluated its efficacy and safety based on randomised controlled trial (RCT) evidence. Methods: PubMed, Embase, and the Cochrane Library were searched through August 2025 for RCTs comparing RLRL with control in children (< 18 years). The primary outcome was spherical equivalent refraction (SER); secondary outcomes included axial length (AL), choroidal thickness (ChT), anterior chamber depth (ACD), central corneal thickness (CCT), lens thickness (LT), and uncorrected visual acuity (UCVA). Evidence certainty was assessed using the GRADE framework. Results: Twenty-eight RCTs (3573 participants) were included. RLRL therapy achieved duration-dependent myopia control (p < 0.05), with pooled improvements versus control at 12 months of +0.68 D in SER, -0.30 mm in AL, and +26.7 μm in ChT. Subgroup analysis showed greater efficacy in children with higher baseline myopia (p < 0.0001), with comparable effects between 5- and 7-day regimens. UCVA was higher with RLRL therapy. ACD, CCT, and LT were unchanged. Reported adverse events were mild and transient, with no consistent structural or functional abnormalities described. Conclusions: RLRL was associated with duration-dependent reductions in myopia progression up to 1 year. Reported structural parameters remained stable and adverse events were generally mild. Moderate-certainty evidence supports improvement in SER and ChT, whereas evidence for AL remains of lower certainty. Longer-term trials incorporating comprehensive retinal safety assessment are required. Trial Registration: PROSPERO CRD420251112677. (© 2026 The Author(s). Clinical & Experimental Ophthalmology published by John Wiley & Sons Australia, Ltd on behalf of Royal Australian and New Zealand College of Ophthalmologists.) |
| References: | JAMA Pediatr. 2024 Jun 1;178(6):533-539. (PMID: 38587852) Eye (Lond). 2023 Nov;37(16):3461-3469. (PMID: 37106147) Int Ophthalmol. 2023 Oct;43(10):3549-3558. (PMID: 37318667) Eur J Ophthalmol. 2025 Jul;35(4):1432-1444. (PMID: 39981627) Asia Pac J Ophthalmol (Phila). 2025 Mar-Apr;14(2):100115. (PMID: 39626798) J Clin Med. 2025 Feb 28;14(5):. (PMID: 40095679) Cochrane Database Syst Rev. 2025 Feb 13;2:CD014758. (PMID: 39945354) Ophthalmic Physiol Opt. 2025 Jan;45(1):160-176. (PMID: 39530399) Ophthalmic Physiol Opt. 2022 Mar;42(2):335-344. (PMID: 34981548) Biomed Res Int. 2021 Jan 27;2021:8915867. (PMID: 33575355) Invest Ophthalmol Vis Sci. 2019 Feb 28;60(3):M106-M131. (PMID: 30817829) PLoS Med. 2009 Jul 21;6(7):e1000097. (PMID: 19621072) J Clin Med. 2022 Oct 11;11(20):. (PMID: 36294321) Asia Pac J Ophthalmol (Phila). 2024 Nov-Dec;13(6):100124. (PMID: 39672511) JAMA Ophthalmol. 2017 Jun 1;135(6):624-630. (PMID: 28494063) Semin Ophthalmol. 2025 Jul;40(5):358-363. (PMID: 39826095) Transl Vis Sci Technol. 2024 Jun 3;13(6):23. (PMID: 38940757) Photodiagnosis Photodyn Ther. 2025 Aug;54:104651. (PMID: 40449858) Int J Ophthalmol. 2021 Apr 18;14(4):606-615. (PMID: 33875955) BMJ. 2008 Apr 26;336(7650):924-6. (PMID: 18436948) Clin Exp Ophthalmol. 2022 Dec;50(9):1013-1024. (PMID: 36054314) Ophthalmology. 2024 Nov;131(11):1304-1313. (PMID: 38763303) Eye Contact Lens. 2016 Jan;42(1):35-42. (PMID: 26704136) Ophthalmol Ther. 2022 Dec;11(6):2259-2270. (PMID: 36208391) Ophthalmol Ther. 2024 Mar;13(3):739-759. (PMID: 38198054) Indian J Ophthalmol. 2024 Feb 1;72(Suppl 2):S203-S210. (PMID: 38099371) Acta Ophthalmol. 2025 Dec;103(8):939-965. (PMID: 40219611) Asia Pac J Ophthalmol (Phila). 2023 Jul-Aug 01;12(4):377-383. (PMID: 37523429) J Clin Med. 2021 Nov 22;10(22):. (PMID: 34830743) JAMA Ophthalmol. 2025 Jun 01;143(6):480-488. (PMID: 40272813) Optom Vis Sci. 2023 Dec 1;100(12):812-822. (PMID: 37890098) Invest Ophthalmol Vis Sci. 2019 Feb 28;60(3):M20-M30. (PMID: 30817826) Transl Vis Sci Technol. 2022 Oct 3;11(10):33. (PMID: 36269184) Am J Ophthalmol. 2025 Feb;270:203-215. (PMID: 39424029) Br J Ophthalmol. 2024 Aug 22;108(9):1299-1305. (PMID: 38631861) JAMA Ophthalmol. 2015 Jun;133(6):683-9. (PMID: 25837970) Sci Rep. 2025 Aug 21;15(1):30794. (PMID: 40841455) Front Med (Lausanne). 2025 Aug 13;12:1640403. (PMID: 40880774) Ophthalmology. 2023 Mar;130(3):286-296. (PMID: 36240954) Br J Ophthalmol. 2025 Oct 23;109(11):1215-1220. (PMID: 40610049) Photodiagnosis Photodyn Ther. 2025 Aug;54:104584. (PMID: 40252784) BMC Ophthalmol. 2024 Feb 20;24(1):78. (PMID: 38378527) Ophthalmology. 2022 May;129(5):509-519. (PMID: 34863776) JAMA Ophthalmol. 2026 Mar 01;144(3):255-258. (PMID: 41642586) Curr Eye Res. 2025 Nov;50(11):1085-1093. (PMID: 40528385) Photomed Laser Surg. 2012 Mar;30(3):167-71. (PMID: 22235969) Ophthalmic Res. 2023;66(1):664-671. (PMID: 36858031) Ophthalmology. 2016 May;123(5):1036-42. (PMID: 26875007) Cochrane Database Syst Rev. 2023 Feb 16;2:CD014758. (PMID: 36809645) Ophthalmology. 2024 Nov;131(11):1314-1323. (PMID: 38849054) Transl Vis Sci Technol. 2025 Apr 1;14(4):22. (PMID: 40266603) Front Med (Lausanne). 2025 Mar 25;12:1542620. (PMID: 40201319) Ophthalmol Ther. 2023 Apr;12(2):1223-1237. (PMID: 36790672) Ophthalmic Epidemiol. 2026 Jun;33(3):266-274. (PMID: 40388203) JAMA Ophthalmol. 2024 Jun 1;142(6):560-567. (PMID: 38662345) J Clin Med. 2022 Dec 17;11(24):. (PMID: 36556114) Clinics (Sao Paulo). 2024 May 8;79:100375. (PMID: 38723579) JAMA Netw Open. 2023 Apr 3;6(4):e239612. (PMID: 37099298) J Clin Med. 2024 Dec 27;14(1):. (PMID: 39797167) Am J Ophthalmol. 2023 Aug;252:153-163. (PMID: 37030495) Photodiagnosis Photodyn Ther. 2024 Jun;47:104198. (PMID: 38729232) Ophthalmology. 2023 Feb;130(2):198-204. (PMID: 36049646) BMJ Open Ophthalmol. 2025 Mar 23;10(1):. (PMID: 40122571) Clin Exp Ophthalmol. 2025 Mar;53(2):119-132. (PMID: 39501548) Eye Contact Lens. 2023 Oct 1;49(10):438-446. (PMID: 37565498) Photodiagnosis Photodyn Ther. 2025 Apr;52:104499. (PMID: 39889976) Lasers Med Sci. 2025 Feb 15;40(1):95. (PMID: 39954097) Ophthalmology. 2024 Jan;131(1):48-57. (PMID: 37634757) Invest Ophthalmol Vis Sci. 2020 Apr 9;61(4):49. (PMID: 32347918) Sci Rep. 2023 Feb 27;13(1):3321. (PMID: 36849626) Photodiagnosis Photodyn Ther. 2024 Oct;49:104267. (PMID: 39009205) Graefes Arch Clin Exp Ophthalmol. 2023 Feb;261(2):575-584. (PMID: 35976467) |
| Contributed Indexing: | Keywords: anterior chamber depth; meta‐analysis; myopia; paediatric ophthalmology; repeated low‐level red‐light therapy |
| Entry Date(s): | Date Created: 20260318 Date Completed: 20260707 Latest Revision: 20260813 |
| Update Code: | 20260813 |
| PubMed Central ID: | PMC13340503 |
| DOI: | 10.1111/ceo.70105 |
| PMID: | 41846466 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1442-9071 |
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| DOI: | 10.1111/ceo.70105 |