Academic Journal
Histone lactylation: A sensor of epigenetic reprogramming mediated by cellular metabolism.
| Τίτλος: | Histone lactylation: A sensor of epigenetic reprogramming mediated by cellular metabolism. |
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| Συγγραφείς: | Wang L; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China., Song S; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China., Yao S; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China., Wang Z; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China., Li Q; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China., Ma Z; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China., Li J; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China., Li Y; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China., Yang M; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China., Zhang K; Chongqing Animal Husbandry Technology Extension Station, Chongqing 401121, China., Han Y; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China. Electronic address: hyg2015@swu.edu.cn., Xu D; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China. Electronic address: xdj2020@swu.edu.cn., Zhao Z; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China. Electronic address: zhaozhongquan@swu.edu.cn. |
| Πηγή: | Cellular signalling [Cell Signal] 2026 Jul; Vol. 143, pp. 112483. Date of Electronic Publication: 2026 Mar 13. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8904683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3913 (Electronic) Linking ISSN: 08986568 NLM ISO Abbreviation: Cell Signal Subsets: MEDLINE |
| Imprint Name(s): | Publication: Oxford : Elsevier Science Ltd Original Publication: Oxford ; New York : Pergamon Press, 1988- |
| Ιατρικοί όροι (MeSH): | Histones*/metabolism , Epigenesis, Genetic* , Cellular Reprogramming*, Humans ; Animals ; Acetylation ; Protein Processing, Post-Translational ; Transcription, Genetic |
| Περίληψη: | Epigenetic reprogramming plays a critical role in connecting genotype to phenotype, providing the flexibility that allows organisms to adapt to developmental needs, environmental shifts, and disease challenges through the flexible regulation of gene expression. Histone lactylation, a recent modification in the field of epigenetic regulation, directly associates metabolic products-lactate-with chromatin modifications, revealing how cellular metabolism regulates the epigenetic landscape. In this review, we discuss the effects of histone lactylation on transcription and its metabolic regulatory mechanisms, explore the interplay between subnuclear metabolic microdomains and histone acetylation, and highlight the specific 'writing,' 'erasing,' and 'reading' enzymes involved in histone lactylation. Additionally, we discuss the physiological functions and recent advancements in the understanding of histone lactylation in disease progression, emphasizing its scientific significance for future research. (Copyright © 2026 Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Cellular metabolism; Disease progression; Epigenetics; Histone lactylation; Transcription |
| Substance Nomenclature: | 0 (Histones) |
| Entry Date(s): | Date Created: 20260316 Date Completed: 20260711 Latest Revision: 20260711 |
| Update Code: | 20260711 |
| DOI: | 10.1016/j.cellsig.2026.112483 |
| PMID: | 41833774 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1873-3913 |
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| DOI: | 10.1016/j.cellsig.2026.112483 |