Academic Journal
Cornuside alleviates microglia-mediated neuroinflammation to ameliorate chronic neuropathic pain-induced cognitive impairment via the Nrf2/Sirt3 signaling pathway.
| Τίτλος: | Cornuside alleviates microglia-mediated neuroinflammation to ameliorate chronic neuropathic pain-induced cognitive impairment via the Nrf2/Sirt3 signaling pathway. |
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| Συγγραφείς: | Yin J; Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China., Chu L; Department of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China., Chen Y; Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China., Fan L; Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China., Wang X; Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China., Wen Y; Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China., He L; Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address: 2025TJ0059@hust.edu.cn. |
| Πηγή: | Free radical biology & medicine [Free Radic Biol Med] 2026 Jun; Vol. 249, pp. 292-307. Date of Electronic Publication: 2026 Mar 12. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE |
| Imprint Name(s): | Publication: Tarrytown, NY : Elsevier Science Original Publication: New York : Pergamon, c1987- |
| Ιατρικοί όροι (MeSH): | Microglia*/drug effects , Microglia*/pathology , Microglia*/metabolism , NF-E2-Related Factor 2*/metabolism , NF-E2-Related Factor 2*/genetics , Neuralgia*/drug therapy , Neuralgia*/complications , Neuralgia*/pathology , Cognitive Dysfunction*/drug therapy , Cognitive Dysfunction*/etiology , Cognitive Dysfunction*/pathology , Cognitive Dysfunction*/metabolism , Sirtuin 3*/metabolism , Sirtuin 3*/genetics , Glycosides*/pharmacology , Neuroinflammatory Diseases*/drug therapy , Neuroinflammatory Diseases*/pathology , Flavonoids*/pharmacology , Chronic Pain*/drug therapy , Chronic Pain*/complications, Signal Transduction/drug effects ; Cornus/chemistry ; Inflammation/drug therapy ; Animals ; Mice ; Male ; Humans ; Disease Models, Animal ; Glucosides ; Pyrans |
| Περίληψη: | Cognitive impairment induced by chronic neuropathic pain (CNP-CI) is a severe complication that markedly compromises patients' quality of life, functional independence, and overall disease burden. However, current pain management strategies demonstrate limited efficacy in preventing or reversing this cognitive decline. Cornuside, an active flavonoid glycoside isolated from the traditional Chinese herb Cornus officinalis, demonstrates potent anti-inflammatory and antioxidative stress properties, however, its therapeutic potential for the treatment of neuropathic pain remains to be elucidated. In this study, we demonstrated that cornuside effectively alleviated microglial inflammation and improved cognitive impairment induced by chronic neuropathic pain. Mechanistically, cornuside ameliorated microglia-mediated neuroinflammation through activation of the Nrf2/Sirt3 signaling pathway and enhancement of mitophagy. Notably, pharmacological inhibition of Sirt3 markedly counteracted the therapeutic effects of cornuside on microglial inflammation and CNP-CI. Our findings provide new insights into the pharmacological mechanisms of cornuside and suggest its potential as a viable therapeutic approach for CNP-CI. (Copyright © 2026 Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of interest The authors declare no competing interests. |
| Contributed Indexing: | Keywords: CNP-CI; Cornuside; Inflammation; Microglia; Nrf2; Sirt3 |
| Substance Nomenclature: | 0 (NF-E2-Related Factor 2) EC 3.5.1.- (Sirtuin 3) 131189-57-6 (cornuside) 0 (Nfe2l2 protein, mouse) 0 (Glycosides) 0 (Sirt3 protein, mouse) 0 (Flavonoids) 0 (Glucosides) 0 (Pyrans) |
| Entry Date(s): | Date Created: 20260314 Date Completed: 20260710 Latest Revision: 20260710 |
| Update Code: | 20260711 |
| DOI: | 10.1016/j.freeradbiomed.2026.03.038 |
| PMID: | 41831801 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1873-4596 |
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| DOI: | 10.1016/j.freeradbiomed.2026.03.038 |