Academic Journal
Communication breakdown: senescent cells in interorgan communication of aging.
| Τίτλος: | Communication breakdown: senescent cells in interorgan communication of aging. |
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| Συγγραφείς: | Ghosh R; Columbia Center for Translational Immunology and Burch-Lodge Center for Human Longevity, Department of Medicine, Columbia University Medical Center, New York, NY, USA., Dipali SS; Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, NY, USA., Desdín-Míco G; Department of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland. Electronic address: gabriela.desdin@unil.ch., Yousefzadeh MJ; Columbia Center for Translational Immunology and Burch-Lodge Center for Human Longevity, Department of Medicine, Columbia University Medical Center, New York, NY, USA. Electronic address: mjy2118@cumc.columbia.edu. |
| Πηγή: | Trends in endocrinology and metabolism: TEM [Trends Endocrinol Metab] 2026 Oct; Vol. 37 (10), pp. 918-926. Date of Electronic Publication: 2026 Mar 11. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Pub. Co Country of Publication: United States NLM ID: 9001516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3061 (Electronic) Linking ISSN: 10432760 NLM ISO Abbreviation: Trends Endocrinol Metab Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: New York : Elsevier Science Pub. Co., [c1989- |
| Ιατρικοί όροι (MeSH): | Cellular Senescence*/physiology , Cellular Senescence*/genetics , Aging*/physiology , Cell Communication*/physiology, Inflammation/metabolism ; Humans ; Animals |
| Περίληψη: | Cellular senescence is a complex cell fate characterized by stable cell cycle arrest and other heterogeneous changes. Senescent cells play a causal role in aging, although the underlying mechanisms remain under active investigation. In this opinion article, we propose that senescent cells can act as key mediators of interorgan communication of aging. Recent work defines multifaceted mechanisms, including the production of senescence-associated secretory phenotype factors that act to propagate senescence signals to nearby and distant cells, as well as age-related alterations in immune function that drive chronic inflammation, known as 'inflammaging'. Further investigation of these mechanisms could yield improved strategies to target senescent cells and mitigate their effects on systemic aging via interorgan communication of aging. (Copyright © 2026 Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of interests No interests are declared. |
| Grant Information: | R21 AG087361 United States AG NIA NIH HHS |
| Contributed Indexing: | Keywords: cellular senescence; immunosenescence; inflammaging; inflammation; interorgan aging |
| Entry Date(s): | Date Created: 20260311 Date Completed: 20261005 Latest Revision: 20261007 |
| Update Code: | 20261007 |
| PubMed Central ID: | PMC12991428 |
| DOI: | 10.1016/j.tem.2026.02.002 |
| PMID: | 41813553 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1879-3061 |
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| DOI: | 10.1016/j.tem.2026.02.002 |