Academic Journal
Two decades of induced pluripotent stem cell research: From discovery to diverse applications.
| Τίτλος: | Two decades of induced pluripotent stem cell research: From discovery to diverse applications. |
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| Συγγραφείς: | Yamanaka S; Gladstone Institute of Cardiovascular Diseases, San Francisco, CA, USA; Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan; CiRA Foundation, Kyoto, Japan. Electronic address: yamanaka@cira.kyoto-u.ac.jp. |
| Πηγή: | Cell stem cell [Cell Stem Cell] 2026 Mar 05; Vol. 33 (3), pp. 372-381. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Cell Press Country of Publication: United States NLM ID: 101311472 Publication Model: Print Cited Medium: Internet ISSN: 1875-9777 (Electronic) Linking ISSN: 18759777 NLM ISO Abbreviation: Cell Stem Cell Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Cambridge, MA : Cell Press |
| Ιατρικοί όροι (MeSH): | Induced Pluripotent Stem Cells*/cytology , Stem Cell Research*, Animals ; Humans ; Cellular Reprogramming ; Regenerative Medicine |
| Περίληψη: | Twenty years have passed since the first demonstration of mouse induced pluripotent stem cells (iPSCs). What began as an unexpected observation in Kyoto quickly transformed stem cell biology and regenerative medicine worldwide. Over the past two decades, we have gained profound insights into the molecular mechanisms underlying cellular reprogramming and pluripotency. The technology has continued to evolve-becoming safer, more efficient, and more versatile. Today, iPSCs serve as a foundation for wide-ranging applications, from disease modeling and drug discovery to regenerative therapies and rejuvenation research. In this review, I reflect on the scientific journey of iPSCs, highlight key milestones in our understanding of reprogramming, and discuss the expanding clinical and societal impact of iPSCs. (Copyright © 2026 The Author. Published by Elsevier Inc. All rights reserved.) |
| Contributed Indexing: | Keywords: iPS cells; medical application; reprogramming |
| Entry Date(s): | Date Created: 20260308 Date Completed: 20260710 Latest Revision: 20260710 |
| Update Code: | 20260711 |
| DOI: | 10.1016/j.stem.2026.02.003 |
| PMID: | 41795426 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1875-9777 |
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| DOI: | 10.1016/j.stem.2026.02.003 |