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Reorganization of Directed Corticomuscular Network via Median Nerve Stimulation in Cervical Dystonia.

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Τίτλος: Reorganization of Directed Corticomuscular Network via Median Nerve Stimulation in Cervical Dystonia.
Συγγραφείς: Chen RK; Department of Neurology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; Department of Neurology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China., Shi WX; Department of Fujian Provincial Key Laboratory of Medical Instrument and Pharmaceutical Technology, Fuzhou University, Fuzhou, China.; College of Electrical Engineering and Automation, Fuzhou University, Fuzhou, China., He YF; Department of Neurology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; Department of Neurology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China., Lin J; Department of Neurology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; Department of Neurology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China., Wang JM; Department of Neurology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; Department of Neurology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China., Shi YY; Department of Neurology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; Department of Neurology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China., Li YR; Department of Fujian Provincial Key Laboratory of Medical Instrument and Pharmaceutical Technology, Fuzhou University, Fuzhou, China.; College of Electrical Engineering and Automation, Fuzhou University, Fuzhou, China., Cai NQ; Department of Neurology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; Department of Neurology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
Πηγή: Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2026 Jun; Vol. 41 (6), pp. 1391-1401. Date of Electronic Publication: 2026 Mar 05.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8610688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-8257 (Electronic) Linking ISSN: 08853185 NLM ISO Abbreviation: Mov Disord Subsets: MEDLINE
Imprint Name(s): Publication: <2001->: New York, NY : Wiley-Liss
Original Publication: [New York, N.Y.] : Raven Press, [c1986-
Ιατρικοί όροι (MeSH): Median Nerve*/physiology , Median Nerve*/physiopathology , Torticollis*/therapy , Torticollis*/physiopathology , Muscle, Skeletal*/physiopathology , Motor Cortex*/physiopathology , Electric Stimulation Therapy*/methods, Electric Stimulation/methods ; Humans ; Female ; Male ; Middle Aged ; Electromyography ; Electroencephalography ; Adult ; Aged
Περίληψη: Background: Cervical dystonia (CD) originates in dysfunctional sensorimotor integration, creating an urgent need for neuromodulatory interventions that recalibrate pathological corticomuscular circuits.
Objective: The aim of this study was to investigate whether median nerve electrical stimulation (MNES) can serve as a novel, noninvasive therapy that specifically targets the abnormal corticomuscular network.
Methods: We investigated high-density electroencephalography combined with synchronized electromyography (EMG) recordings from 17 patients and 17 healthy control subjects during MNES and sensory trick (ST) tasks. Source-localized cortical activity and muscle signals were integrated into a directional corticomuscular network, with connectivity quantified by phase transfer entropy.
Results: MNES selectively suppressed pathological 4 to 8 Hz intermuscular coupling in patients, reorganized aberrant muscle synergy, and drove frequency-specific network reorganization: reduced beta-band outflow, decreased clustering coefficients, and prolonged the shortest path lengths across multiple frequency bands. Crucially, MNES enhanced hemispheric asymmetry in primary sensory cortex, supplementary motor area, and cerebellum. Operating predominantly in theta/alpha bands, MNES contrasted sharply with ST's gamma-band modulation.
Conclusions: These findings demonstrate that MNES restores corticomuscular network dynamics through multilever reconfiguration, attenuating pathological synchrony while facilitating adaptive circuit plasticity, thereby validating directed network analysis as a framework for circuit-targeted neuromodulation in movement disorders. © 2026 International Parkinson and Movement Disorder Society.
(© 2026 International Parkinson and Movement Disorder Society.)
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Grant Information: 2024Y9147 the Joint Funds for the Innovation of Science and Technology; 62373108 National Natural Science Foundation of China
Contributed Indexing: Keywords: EEG; cervical dystonia; directed corticomuscular network; median nerve electrical stimulation; sensory trick
Entry Date(s): Date Created: 20260305 Date Completed: 20260626 Latest Revision: 20260626
Update Code: 20260627
DOI: 10.1002/mds.70260
PMID: 41786661
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1531-8257
DOI:10.1002/mds.70260