Academic Journal
Brain natriuretic peptide protects against acute pulmonary embolism-induced pulmonary vasoconstriction through natriuretic peptide receptor C.
| Τίτλος: | Brain natriuretic peptide protects against acute pulmonary embolism-induced pulmonary vasoconstriction through natriuretic peptide receptor C. |
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| Συγγραφείς: | Gao Y; Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang, China., Liu S; Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang, China., Gu Z; Department of Pharmacy, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Wei X; Department of Public Health Sciences, Queen's University, Kingston, ON, Canada., Han X; Department of Medical Basic Experimental Teaching Center, China Medical University, Shenyang, China., Wei S; Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, China., Yang J; Department of Endocrinology, The Fourth Affiliated Hospital of China Medical University, Shenyang, China., Liu Y; Department of Hernia and Abdominal Wall Surgery, Beijing Chaoyang Hospital, Capital Medical University, Chaoyang, Beijing, China., Jia D; Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang, China. djia@cmu.edu.cn. |
| Πηγή: | Basic research in cardiology [Basic Res Cardiol] 2026 Jun; Vol. 121 (3), pp. 555-572. Date of Electronic Publication: 2026 Mar 05. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Steinkopff Country of Publication: Germany NLM ID: 0360342 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-1803 (Electronic) Linking ISSN: 03008428 NLM ISO Abbreviation: Basic Res Cardiol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Darmstadt, Steinkopff. |
| Ιατρικοί όροι (MeSH): | Vasoconstriction*/drug effects , Pulmonary Embolism*/physiopathology , Pulmonary Embolism*/drug therapy , Pulmonary Embolism*/metabolism , Natriuretic Peptide, Brain*/pharmacology , Natriuretic Peptide, Brain*/administration & dosage , Pulmonary Artery*/drug effects , Pulmonary Artery*/metabolism , Pulmonary Artery*/physiopathology , Receptors, Atrial Natriuretic Factor*/metabolism, Oxidative Stress/drug effects ; Animals ; Male ; Disease Models, Animal ; Humans ; Rats ; Rats, Sprague-Dawley ; Acute Disease |
| Περίληψη: | Acute pulmonary embolism (PE) remains a leading cause of cardiovascular mortality, driven primarily by a sudden increase in pulmonary artery (PA) resistance. Brain Natriuretic Peptide (BNP) may hold promise for reducing PA resistance. However, its role and mechanism in acute PE are not yet fully understood. This study aims to determine whether BNP alleviates PE-induced pulmonary vasoconstriction by targeting Natriuretic Peptide Receptor C (NPRC) and evaluate its therapeutic potential. Here, we established an acute PE rat model using autologous thrombi, and right ventricle (RV) pressure was monitored to approximate PA resistance. A small group of intermediate-high-risk acute PE patients were observed, who received BNP in addition to anticoagulation, and their clinical outcomes were compared to matched patients receiving anticoagulation alone. BNP at varying doses was administered to optimize therapeutic efficacy in the acute PE rat model. Mechanistic studies assessed BNP's impact on oxidative stress in PA endothelium. In the rats, BNP infusion significantly reduced RV pressure overload and improved survival. Clinically, patients receiving adjunctive BNP experienced more rapid improvement in heart rate, oxygen saturation, and blood pressure stability than anticoagulation alone. BNP decreased NADPH oxidase 2-dependent ROS levels in rats' PA endothelium, thereby reducing myosin light chain phosphorylation in smooth muscle. NPRC, as the central receptor, antagonizes the protective effect of BNP. Collectively, BNP offers a novel choice to mitigate PE-induced pulmonary vasoconstriction via NPRC-mediated mechanisms, which support BNP's therapeutic potential for intermediate-high-risk PE. (© 2026. Springer-Verlag GmbH Germany, part of Springer Nature.) |
| Competing Interests: | Declarations. Competing interests: The authors have no conflicts to declare. |
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| Grant Information: | 2023JH2/10600025 Applied Basic Research Plan Project of Liaoning Province; PG2023007 Beijing Municipal Administration of Hospitals Incubating Program; 2024-N012-04 Medical Education Research Project in Liaoning Province |
| Contributed Indexing: | Keywords: Brain natriuretic peptide; NADPH oxidase 2; Natriuretic peptide receptor C; Pulmonary embolism; Pulmonary vasoconstriction |
| Substance Nomenclature: | 114471-18-0 (Natriuretic Peptide, Brain) EC 4.6.1.2 (Receptors, Atrial Natriuretic Factor) EC 4.6.1.2 (atrial natriuretic factor receptor C) |
| Entry Date(s): | Date Created: 20260304 Date Completed: 20260710 Latest Revision: 20260710 |
| Update Code: | 20260711 |
| DOI: | 10.1007/s00395-026-01166-9 |
| PMID: | 41781760 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1435-1803 |
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| DOI: | 10.1007/s00395-026-01166-9 |