Academic Journal
Προβολή σε EDS

Bioactive potential of the tube anemone Ceriantheomorphe brasiliensis: anticancer and antiviral properties from its crude extract.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Bioactive potential of the tube anemone Ceriantheomorphe brasiliensis: anticancer and antiviral properties from its crude extract.
Συγγραφείς: Pereira GHF; Universidade Estadual Paulista, Assis, SP, Brasil., Cruz D; Universidade Estadual Paulista, Faculdade de Ciências, Departamento de Ciências Biológicas, Laboratório de Evolução e Diversidade Aquática, Bauru, SP, Brasil.; Universidade Estadual Paulista, Instituto de Biociências, Pós-graduação em Ciências Biológicas (Zoologia), Botucatu, SP, Brasil., Silva Júnior R; Universidade Estadual Paulista, Assis, SP, Brasil.; Universidade Estadual Paulista, Instituto de Biociências, Letras e Ciências Exatas, Pós-graduação em Microbiologia, São José do Rio Preto, SP, Brasil., Pinto LS; Universidade Estadual Paulista, Assis, SP, Brasil., Stampar SN; Universidade Estadual Paulista, Faculdade de Ciências, Departamento de Ciências Biológicas, Laboratório de Evolução e Diversidade Aquática, Bauru, SP, Brasil.; Universidade Estadual Paulista, Instituto de Biociências, Pós-graduação em Ciências Biológicas (Zoologia), Botucatu, SP, Brasil., Toledo KA; Universidade Estadual Paulista, Assis, SP, Brasil.; Universidade Estadual Paulista, Instituto de Biociências, Letras e Ciências Exatas, Pós-graduação em Microbiologia, São José do Rio Preto, SP, Brasil.
Πηγή: Brazilian journal of biology = Revista brasleira de biologia [Braz J Biol] 2026 Mar 02; Vol. 85, pp. e297214. Date of Electronic Publication: 2026 Mar 02 (Print Publication: 2026).
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: International Institute of Ecology Country of Publication: Brazil NLM ID: 101129542 Publication Model: eCollection Cited Medium: Internet ISSN: 1678-4375 (Electronic) Linking ISSN: 15196984 NLM ISO Abbreviation: Braz J Biol Subsets: MEDLINE
Imprint Name(s): Original Publication: São Carlos, SP [Brazil] : International Institute of Ecology, [2000]-
Ιατρικοί όροι (MeSH): Antiviral Agents*/pharmacology , Antiviral Agents*/isolation & purification , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/isolation & purification , Anemone*/chemistry , Complex Mixtures*/pharmacology, Cell Survival/drug effects ; Animals ; Humans ; Chlorocebus aethiops ; Cell Line, Tumor
Περίληψη: The marine ecosystem is vast and houses an immense diversity of niches and species. In this context, the phylum Cnidaria is one of the main marine phyla and is present in every ocean on Earth. Cnidarians have cells called cnidoblasts, which may inoculate many toxic compounds. Currently, the search for compounds with pharmacological relevance in the aquatic environment has intensified, and further studies are necessary. In this study, the crude extract from the cnidarian Ceriantheomorphe brasiliensis (CB) tentacles was evaluated for its antitumoral and antiviral activity. For this purpose, the cell viability of different tumor cells and virus-infected cells, after treatment with CB crude extract, was measured by using the MTT assay. The electrophoretic profile of CB crude extract showed proteins in the ranges of 15, 25-50, and 100-250 kDa. Considering that 34.38-53.98 µg of CB was able to kill non-tumorigenic (Vero) cells, antitumoral activity was observed against MCF-7, HEp-G2, and HEp-2 cells since lower concentrations were toxic for these tumors. These promising effects were not observed when Caco-2 and A549 were analyzed. In addition, HEp-2 cells were protected from viral infection when respiratory syncytial virus (RSV) was previously treated with CB extract (5.57 µg/ml). Pre-treatment and post-treatment were not effective. Altogether, we expanded the description of antitumoral activities of crude extract from Cnidaria and demonstrated for the first-time the virucidal effect from this phylum.
Substance Nomenclature: 0 (Antiviral Agents)
0 (Antineoplastic Agents)
0 (Complex Mixtures)
Entry Date(s): Date Created: 20260304 Date Completed: 20260710 Latest Revision: 20260710
Update Code: 20260711
DOI: 10.1590/1519-6984.297214
PMID: 41779461
Βάση Δεδομένων: MEDLINE
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://resolver.ebsco.com/c/fiv2js/result?sid=EBSCO:cmedm&genre=article&issn=16784375&ISBN=&volume=85&issue=&date=20260302&spage=e297214&pages=e297214&title=Brazilian journal of biology = Revista brasleira de biologia&atitle=Bioactive%20potential%20of%20the%20tube%20anemone%20Ceriantheomorphe%20brasiliensis%3A%20anticancer%20and%20antiviral%20properties%20from%20its%20crude%20extract.&aulast=Pereira%20GHF&id=DOI:10.1590/1519-6984.297214
    Name: Full Text Finder (for New FTF UI) (ns324271)
    Category: fullText
    Text: Full Text Finder
    MouseOverText: Full Text Finder
Header DbId: cmedm
DbLabel: MEDLINE
An: 41779461
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Bioactive potential of the tube anemone Ceriantheomorphe brasiliensis: anticancer and antiviral properties from its crude extract.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Pereira+GHF%22">Pereira GHF</searchLink>; Universidade Estadual Paulista, Assis, SP, Brasil.<br /><searchLink fieldCode="AU" term="%22Cruz+D%22">Cruz D</searchLink>; Universidade Estadual Paulista, Faculdade de Ciências, Departamento de Ciências Biológicas, Laboratório de Evolução e Diversidade Aquática, Bauru, SP, Brasil.; Universidade Estadual Paulista, Instituto de Biociências, Pós-graduação em Ciências Biológicas (Zoologia), Botucatu, SP, Brasil.<br /><searchLink fieldCode="AU" term="%22Silva+Júnior+R%22">Silva Júnior R</searchLink>; Universidade Estadual Paulista, Assis, SP, Brasil.; Universidade Estadual Paulista, Instituto de Biociências, Letras e Ciências Exatas, Pós-graduação em Microbiologia, São José do Rio Preto, SP, Brasil.<br /><searchLink fieldCode="AU" term="%22Pinto+LS%22">Pinto LS</searchLink>; Universidade Estadual Paulista, Assis, SP, Brasil.<br /><searchLink fieldCode="AU" term="%22Stampar+SN%22">Stampar SN</searchLink>; Universidade Estadual Paulista, Faculdade de Ciências, Departamento de Ciências Biológicas, Laboratório de Evolução e Diversidade Aquática, Bauru, SP, Brasil.; Universidade Estadual Paulista, Instituto de Biociências, Pós-graduação em Ciências Biológicas (Zoologia), Botucatu, SP, Brasil.<br /><searchLink fieldCode="AU" term="%22Toledo+KA%22">Toledo KA</searchLink>; Universidade Estadual Paulista, Assis, SP, Brasil.; Universidade Estadual Paulista, Instituto de Biociências, Letras e Ciências Exatas, Pós-graduação em Microbiologia, São José do Rio Preto, SP, Brasil.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101129542%22">Brazilian journal of biology = Revista brasleira de biologia</searchLink> [Braz J Biol] 2026 Mar 02; Vol. 85, pp. e297214. <i>Date of Electronic Publication: </i>2026 Mar 02 (<i>Print Publication: </i>2026).
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22International+Institute+of+Ecology%22">International Institute of Ecology </searchLink><i>Country of Publication: </i>Brazil <i>NLM ID: </i>101129542 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1678-4375 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215196984%22">15196984 </searchLink><i>NLM ISO Abbreviation: </i>Braz J Biol <i>Subsets: </i>MEDLINE
– Name: PublisherInfo
  Label: Imprint Name(s)
  Group: PubInfo
  Data: <i>Original Publication</i>: São Carlos, SP [Brazil] : International Institute of Ecology, [2000]-
– Name: SubjectMESH
  Label: MeSH Terms
  Group: Su
  Data: <searchLink fieldCode="MM" term="%22Antiviral+Agents%22">Antiviral Agents*</searchLink>/<searchLink fieldCode="MM" term="%22Antiviral+Agents+pharmacology%22">pharmacology</searchLink> <br /><searchLink fieldCode="MM" term="%22Antiviral+Agents%22">Antiviral Agents*</searchLink>/<searchLink fieldCode="MM" term="%22Antiviral+Agents+isolation+%26+purification%22">isolation & purification</searchLink> <br /><searchLink fieldCode="MM" term="%22Antineoplastic+Agents%22">Antineoplastic Agents*</searchLink>/<searchLink fieldCode="MM" term="%22Antineoplastic+Agents+pharmacology%22">pharmacology</searchLink> <br /><searchLink fieldCode="MM" term="%22Antineoplastic+Agents%22">Antineoplastic Agents*</searchLink>/<searchLink fieldCode="MM" term="%22Antineoplastic+Agents+isolation+%26+purification%22">isolation & purification</searchLink> <br /><searchLink fieldCode="MM" term="%22Anemone%22">Anemone*</searchLink>/<searchLink fieldCode="MM" term="%22Anemone+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Complex+Mixtures%22">Complex Mixtures*</searchLink>/<searchLink fieldCode="MM" term="%22Complex+Mixtures+pharmacology%22">pharmacology</searchLink><br /><searchLink fieldCode="MH" term="%22Cell+Survival%22">Cell Survival</searchLink>/<searchLink fieldCode="MH" term="%22Cell+Survival+drug+effects%22">drug effects</searchLink> ; <searchLink fieldCode="MH" term="%22Animals%22">Animals</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Chlorocebus+aethiops%22">Chlorocebus aethiops</searchLink> ; <searchLink fieldCode="MH" term="%22Cell+Line%2C+Tumor%22">Cell Line, Tumor</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The marine ecosystem is vast and houses an immense diversity of niches and species. In this context, the phylum Cnidaria is one of the main marine phyla and is present in every ocean on Earth. Cnidarians have cells called cnidoblasts, which may inoculate many toxic compounds. Currently, the search for compounds with pharmacological relevance in the aquatic environment has intensified, and further studies are necessary. In this study, the crude extract from the cnidarian Ceriantheomorphe brasiliensis (CB) tentacles was evaluated for its antitumoral and antiviral activity. For this purpose, the cell viability of different tumor cells and virus-infected cells, after treatment with CB crude extract, was measured by using the MTT assay. The electrophoretic profile of CB crude extract showed proteins in the ranges of 15, 25-50, and 100-250 kDa. Considering that 34.38-53.98 µg of CB was able to kill non-tumorigenic (Vero) cells, antitumoral activity was observed against MCF-7, HEp-G2, and HEp-2 cells since lower concentrations were toxic for these tumors. These promising effects were not observed when Caco-2 and A549 were analyzed. In addition, HEp-2 cells were protected from viral infection when respiratory syncytial virus (RSV) was previously treated with CB extract (5.57 µg/ml). Pre-treatment and post-treatment were not effective. Altogether, we expanded the description of antitumoral activities of crude extract from Cnidaria and demonstrated for the first-time the virucidal effect from this phylum.
– Name: NumberCAS
  Label: Substance Nomenclature
  Group: ID
  Data: 0 (Antiviral Agents)<br />0 (Antineoplastic Agents)<br />0 (Complex Mixtures)
– Name: DateEntry
  Label: Entry Date(s)
  Group: Date
  Data: <i>Date Created: </i>20260304 <i>Date Completed: </i>20260710 <i>Latest Revision: </i>20260710
– Name: DateUpdate
  Label: Update Code
  Group: Date
  Data: 20260711
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1590/1519-6984.297214
– Name: AN
  Label: PMID
  Group: ID
  Data: 41779461
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=41779461
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1590/1519-6984.297214
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: e297214
    Subjects:
      – SubjectFull: Cell Survival drug effects
        Type: general
      – SubjectFull: Animals
        Type: general
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Chlorocebus aethiops
        Type: general
      – SubjectFull: Cell Line, Tumor
        Type: general
      – SubjectFull: Antiviral Agents pharmacology
        Type: general
      – SubjectFull: Antiviral Agents isolation & purification
        Type: general
      – SubjectFull: Antineoplastic Agents pharmacology
        Type: general
      – SubjectFull: Antineoplastic Agents isolation & purification
        Type: general
      – SubjectFull: Anemone chemistry
        Type: general
      – SubjectFull: Complex Mixtures pharmacology
        Type: general
    Titles:
      – TitleFull: Bioactive potential of the tube anemone Ceriantheomorphe brasiliensis: anticancer and antiviral properties from its crude extract.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Pereira GHF
      – PersonEntity:
          Name:
            NameFull: Cruz D
      – PersonEntity:
          Name:
            NameFull: Silva Júnior R
      – PersonEntity:
          Name:
            NameFull: Pinto LS
      – PersonEntity:
          Name:
            NameFull: Stampar SN
      – PersonEntity:
          Name:
            NameFull: Toledo KA
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 02
              M: 03
              Text: 2026 Mar 02
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1678-4375
          Numbering:
            – Type: volume
              Value: 85
          Titles:
            – TitleFull: Brazilian journal of biology = Revista brasleira de biologia
              Type: main
ResultId 1