Academic Journal
Bioactive potential of the tube anemone Ceriantheomorphe brasiliensis: anticancer and antiviral properties from its crude extract.
| Τίτλος: | Bioactive potential of the tube anemone Ceriantheomorphe brasiliensis: anticancer and antiviral properties from its crude extract. |
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| Συγγραφείς: | Pereira GHF; Universidade Estadual Paulista, Assis, SP, Brasil., Cruz D; Universidade Estadual Paulista, Faculdade de Ciências, Departamento de Ciências Biológicas, Laboratório de Evolução e Diversidade Aquática, Bauru, SP, Brasil.; Universidade Estadual Paulista, Instituto de Biociências, Pós-graduação em Ciências Biológicas (Zoologia), Botucatu, SP, Brasil., Silva Júnior R; Universidade Estadual Paulista, Assis, SP, Brasil.; Universidade Estadual Paulista, Instituto de Biociências, Letras e Ciências Exatas, Pós-graduação em Microbiologia, São José do Rio Preto, SP, Brasil., Pinto LS; Universidade Estadual Paulista, Assis, SP, Brasil., Stampar SN; Universidade Estadual Paulista, Faculdade de Ciências, Departamento de Ciências Biológicas, Laboratório de Evolução e Diversidade Aquática, Bauru, SP, Brasil.; Universidade Estadual Paulista, Instituto de Biociências, Pós-graduação em Ciências Biológicas (Zoologia), Botucatu, SP, Brasil., Toledo KA; Universidade Estadual Paulista, Assis, SP, Brasil.; Universidade Estadual Paulista, Instituto de Biociências, Letras e Ciências Exatas, Pós-graduação em Microbiologia, São José do Rio Preto, SP, Brasil. |
| Πηγή: | Brazilian journal of biology = Revista brasleira de biologia [Braz J Biol] 2026 Mar 02; Vol. 85, pp. e297214. Date of Electronic Publication: 2026 Mar 02 (Print Publication: 2026). |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: International Institute of Ecology Country of Publication: Brazil NLM ID: 101129542 Publication Model: eCollection Cited Medium: Internet ISSN: 1678-4375 (Electronic) Linking ISSN: 15196984 NLM ISO Abbreviation: Braz J Biol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: São Carlos, SP [Brazil] : International Institute of Ecology, [2000]- |
| Ιατρικοί όροι (MeSH): | Antiviral Agents*/pharmacology , Antiviral Agents*/isolation & purification , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/isolation & purification , Anemone*/chemistry , Complex Mixtures*/pharmacology, Cell Survival/drug effects ; Animals ; Humans ; Chlorocebus aethiops ; Cell Line, Tumor |
| Περίληψη: | The marine ecosystem is vast and houses an immense diversity of niches and species. In this context, the phylum Cnidaria is one of the main marine phyla and is present in every ocean on Earth. Cnidarians have cells called cnidoblasts, which may inoculate many toxic compounds. Currently, the search for compounds with pharmacological relevance in the aquatic environment has intensified, and further studies are necessary. In this study, the crude extract from the cnidarian Ceriantheomorphe brasiliensis (CB) tentacles was evaluated for its antitumoral and antiviral activity. For this purpose, the cell viability of different tumor cells and virus-infected cells, after treatment with CB crude extract, was measured by using the MTT assay. The electrophoretic profile of CB crude extract showed proteins in the ranges of 15, 25-50, and 100-250 kDa. Considering that 34.38-53.98 µg of CB was able to kill non-tumorigenic (Vero) cells, antitumoral activity was observed against MCF-7, HEp-G2, and HEp-2 cells since lower concentrations were toxic for these tumors. These promising effects were not observed when Caco-2 and A549 were analyzed. In addition, HEp-2 cells were protected from viral infection when respiratory syncytial virus (RSV) was previously treated with CB extract (5.57 µg/ml). Pre-treatment and post-treatment were not effective. Altogether, we expanded the description of antitumoral activities of crude extract from Cnidaria and demonstrated for the first-time the virucidal effect from this phylum. |
| Substance Nomenclature: | 0 (Antiviral Agents) 0 (Antineoplastic Agents) 0 (Complex Mixtures) |
| Entry Date(s): | Date Created: 20260304 Date Completed: 20260710 Latest Revision: 20260710 |
| Update Code: | 20260711 |
| DOI: | 10.1590/1519-6984.297214 |
| PMID: | 41779461 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1678-4375 |
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| DOI: | 10.1590/1519-6984.297214 |