Academic Journal
Synthesis and biological evaluation of novel Kojic acid-cinnamic acid hybrids as tyrosinase inhibitors.
| Τίτλος: | Synthesis and biological evaluation of novel Kojic acid-cinnamic acid hybrids as tyrosinase inhibitors. |
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| Συγγραφείς: | Wen Y; School of Pharmacy and Food Engineering & Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine & International Healthcare Innovation Institute (Jiangmen), Wuyi University, Jiangmen, 529020, China., Yu Q; School of Pharmacy and Food Engineering & Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine & International Healthcare Innovation Institute (Jiangmen), Wuyi University, Jiangmen, 529020, China., Yang F; Jiangmen Customs Technology Center, Jiangmen, 529020, China., Li J; School of Pharmacy and Food Engineering & Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine & International Healthcare Innovation Institute (Jiangmen), Wuyi University, Jiangmen, 529020, China., Lang M; School of Pharmacy and Food Engineering & Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine & International Healthcare Innovation Institute (Jiangmen), Wuyi University, Jiangmen, 529020, China. langm2019@163.com., Yan JL; School of Pharmacy and Food Engineering & Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine & International Healthcare Innovation Institute (Jiangmen), Wuyi University, Jiangmen, 529020, China. yanjialei@wyu.edu.cn., Xu X; School of Pharmacy and Food Engineering & Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine & International Healthcare Innovation Institute (Jiangmen), Wuyi University, Jiangmen, 529020, China. wyuchemxxt@126.com. |
| Πηγή: | Molecular diversity [Mol Divers] 2026 Oct; Vol. 30 (5), pp. 7235-7246. Date of Electronic Publication: 2026 Mar 01. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Leiden, The Netherlands : ESCOM Science Publishers, c1995- |
| Ιατρικοί όροι (MeSH): | Pyrones*/chemistry , Pyrones*/pharmacology , Pyrones*/chemical synthesis , Monophenol Monooxygenase*/antagonists & inhibitors , Monophenol Monooxygenase*/chemistry , Monophenol Monooxygenase*/metabolism , Cinnamates*/chemistry , Cinnamates*/pharmacology , Cinnamates*/chemical synthesis , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemical synthesis , Enzyme Inhibitors*/chemistry, Melanins/biosynthesis ; Molecular Docking Simulation ; Animals ; Mice |
| Περίληψη: | Tyrosinase is the key rate limiting enzyme that controls melanin production. A series of novel kojic acid-cinnamic acid hybrids (JP1~26) were synthesized as tyrosinase inhibitors. All compounds displayed potential anti-tyrosinase activity with IC (© 2026. The Author(s), under exclusive licence to Springer Nature Switzerland AG.) |
| Competing Interests: | Declarations. Conflict of interest: The authors declare no competing interests. |
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| Grant Information: | 2021B1212040016 Science and Technology Planning Project of Guangdong Province |
| Contributed Indexing: | Keywords: Cinnamic acid; Kojic acid; Tyrosinase inhibitors |
| Substance Nomenclature: | 0 (Pyrones) 6K23F1TT52 (kojic acid) EC 1.14.18.1 (Monophenol Monooxygenase) 0 (Cinnamates) 0 (Enzyme Inhibitors) 140-10-3 (cinnamic acid) 0 (Melanins) |
| Entry Date(s): | Date Created: 20260301 Date Completed: 20261006 Latest Revision: 20261008 |
| Update Code: | 20261008 |
| DOI: | 10.1007/s11030-026-11487-5 |
| PMID: | 41764693 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1573-501X |
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| DOI: | 10.1007/s11030-026-11487-5 |