Academic Journal
Crude extract of cyanobacterium (Radiocystis fernandoi) triggers primary osmoregulatory impairment in the gills of nile tilapia (Oreochromis niloticus).
| Τίτλος: | Crude extract of cyanobacterium (Radiocystis fernandoi) triggers primary osmoregulatory impairment in the gills of nile tilapia (Oreochromis niloticus). |
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| Συγγραφείς: | M A M S; Laboratory of Zoophysiology and Comparative Biochemistry, Department of Physiological Sciences, Federal University of São Carlos, São Carlos, São Paulo, Brazil., P G P; Laboratory of Zoophysiology and Comparative Biochemistry, Department of Physiological Sciences, Federal University of São Carlos, São Carlos, São Paulo, Brazil., J P S C; Laboratory of Comparative Animal Morphophysiology, Center of Integrated Sciences, Federal University of Northern Tocantins, Araguaína, Tocantins, Brazil., A G; Department of Botany, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., M N F; Laboratory of Zoophysiology and Comparative Biochemistry, Department of Physiological Sciences, Federal University of São Carlos, São Carlos, São Paulo, Brazil., M G P; Laboratory of Comparative Animal Morphophysiology, Center of Integrated Sciences, Federal University of Northern Tocantins, Araguaína, Tocantins, Brazil. marcelo.paulino@ufnt.edu.br. |
| Πηγή: | Ecotoxicology (London, England) [Ecotoxicology] 2026 Feb 28; Vol. 35 (4). Date of Electronic Publication: 2026 Feb 28. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Kluwer Academic Publishers Country of Publication: United States NLM ID: 9885956 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-3017 (Electronic) Linking ISSN: 09639292 NLM ISO Abbreviation: Ecotoxicology Subsets: MEDLINE |
| Imprint Name(s): | Publication: 1999- : Boston : Kluwer Academic Publishers Original Publication: London : Chapman & Hall |
| Ιατρικοί όροι (MeSH): | Gills*/drug effects , Gills*/physiology , Microcystins*/toxicity , Cichlids*/physiology , Osmoregulation*/drug effects , Cyanobacteria*/chemistry , Water Pollutants, Chemical*/toxicity , Complex Mixtures*/toxicity, Marine Toxins/toxicity ; Animals ; Brazil |
| Περίληψη: | Eutrophication, driven by microalgae proliferation, promotes the production of microcystins (MC), posing global risks to the environment and public health. In Brazil, the species Radiocystis fernandoi commonly produces variants such as MC-RR and MC-YR. However, most toxicological studies still emphasize the isolated hepatoxicity of the MC-LR variant, with limited data on the toxicity of other variants or water exposure of the entire cellular contents released during cyanobacterial lysis. This study assessed acute (12 h and 96 h) effects of waterborne exposure to a crude extract (CE) of R. fernandoi R28 containing MC-RR and YR mostly (10 µg MC-LReq L⁻¹) on juvenile Oreochromis niloticus, focusing on gill osmoregulation and gill and liver tissue integrity. Gill alterations included mucous cell proliferation (12 h) and epithelial disruption with pillar cell changes (96 h), increasing the organ index at 96 h. Plasma chloride decreased at both times, accompanied by a transient rise in branchial carbonic anhydrase activity and lamellar ionocyte abundance at 12 h. Hepatic phosphatase PP1/PP2A, plasmatic acid phosphatase, plasmatic alkaline phosphatase and liver histology remained unaffected. These results show that aqueous exposure to R. fernandoi CE induces acute osmoregulatory impairment, potential disturbances in acid–base regulation, and structural damage in the gills of O. niloticus, even without evident hepatotoxicity. This highlights the gills as a relevant target for less-studied MC congeners and emphasizes the toxicological risks associated with waterborne exposure in eutrophic environments. |
| Competing Interests: | Declarations. Ethics approval: This study was approved by University Federal of São Carlos Animal Ethics Committee (process 039/2014). Conflict of interests: The authors declare no competing interests.. |
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| Contributed Indexing: | Keywords: Aquatic toxicology; Carbonic anhydrase; Crude extract; Cyanobacterium; Eutrophication; Gill ionocytes |
| Substance Nomenclature: | 0 (Microcystins) 0 (Marine Toxins) 0 (Water Pollutants, Chemical) 0 (Complex Mixtures) |
| Entry Date(s): | Date Created: 20260228 Date Completed: 20260627 Latest Revision: 20260920 |
| Update Code: | 20260920 |
| PubMed Central ID: | PMC12950070 |
| DOI: | 10.1007/s10646-026-03049-0 |
| PMID: | 41762321 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1573-3017 |
|---|---|
| DOI: | 10.1007/s10646-026-03049-0 |