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Clinical and radiographic outcomes and associated factors of iRoot BP plus apical barrier treatment in permanent teeth with open apices and periapical lesions: a retrospective study.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Clinical and radiographic outcomes and associated factors of iRoot BP plus apical barrier treatment in permanent teeth with open apices and periapical lesions: a retrospective study.
Συγγραφείς: Wang J; College & Hospital of Stomatology, Anhui Medical University, Anhui Provincial Key Laboratory of Oral Diseases Research, 230032, Hefei, China., Xiang K; Teaching Management Office, College of Stomatology, Anhui Medical University, Hefei, China., Sun C; College & Hospital of Stomatology, Anhui Medical University, Anhui Provincial Key Laboratory of Oral Diseases Research, 230032, Hefei, China., Ren T; College & Hospital of Stomatology, Anhui Medical University, Anhui Provincial Key Laboratory of Oral Diseases Research, 230032, Hefei, China., Zhang H; College & Hospital of Stomatology, Anhui Medical University, Anhui Provincial Key Laboratory of Oral Diseases Research, 230032, Hefei, China. toothyan@126.com.
Πηγή: Clinical oral investigations [Clin Oral Investig] 2026 Feb 28; Vol. 30 (3). Date of Electronic Publication: 2026 Feb 28.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 9707115 Publication Model: Electronic Cited Medium: Internet ISSN: 1436-3771 (Electronic) Linking ISSN: 14326981 NLM ISO Abbreviation: Clin Oral Investig Subsets: MEDLINE
Imprint Name(s): Publication: Berlin : Springer-Verlag
Original Publication: Berlin : Springer, c1997-
Ιατρικοί όροι (MeSH): Silicates*/therapeutic use , Tooth Apex*/diagnostic imaging , Periapical Diseases*/diagnostic imaging , Periapical Diseases*/therapy , Apexification*/methods , Root Canal Filling Materials*/therapeutic use , Dentition, Permanent*, Dental Pulp Necrosis/diagnostic imaging ; Dental Pulp Necrosis/therapy ; Retrospective Studies ; Humans ; Male ; Child ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Radiography, Dental ; Female
Περίληψη: OBJECTIVE: To evaluate clinical and radiographic outcomes of iRoot BP Plus apical barrier treatment in permanent teeth with open apices and periapical lesions and to explore associated factors. METHODS: Permanent teeth exhibiting pulp necrosis and open apices treated with iRoot BP Plus apical barrier were retrospectively included with follow-up ≥ 12 months. Treatment outcomes were determined through clinical examinations and radiographic assessments, with results classified as healed, healing, or failure. Quantitative changes in root length, root width, and apical diameter were measured on paired radiographs. Associations between baseline variables and outcomes were examined using chi-square or Fisher’s exact tests. RESULTS: A total of 54 teeth were included in the final evaluation, with a median follow-up period of 18.5 months (minimum 12 months, maximum 60 months). At final follow-up, 23 teeth (42.6%) were classified as healed, 29 (53.7%) as healing, and 2 (3.7%) as failure. Favorable outcomes (healed and healing) were observed in 52 teeth (96.3%); most teeth (52/54) were asymptomatic. Radiographs showed substantial reduction or resolution of periapical lesions. Periapical index (PAI) was significantly associated with treatment outcome (P < 0.05). Quantitative radiographic measurements indicated increased root length and root width with a reduction in apical diameter during follow-up. CONCLUSION: In this retrospective cohort, iRoot BP Plus apical barrier treatment showed favorable clinical and radiographic outcomes in permanent teeth with open apices and periapical lesions. CLINICAL RELEVANCE: In this study, PAI was associated with treatment outcomes, which may help clinicians in case assessment and follow-up planning.
Competing Interests: Declarations. Ethics approval and consent to participate: All procedures described in this manuscript have been reviewed and approved by the Ethical Committee of the Anhui Stomatological Hospital (approval: NoT2024039). Informed consent was received in writing from all participants. Competing interests: The authors declare no competing interests.
References: J Endod. 2017 Jan;43(1):1-6. (PMID: 27986096)
Aust Endod J. 2024 Apr;50(1):115-122. (PMID: 37994232)
Aust Endod J. 2021 Aug;47(2):178-187. (PMID: 33094527)
J Formos Med Assoc. 2016 Jul;115(7):523-30. (PMID: 26911724)
Eur Endod J. 2021 Apr;6(1):44-49. (PMID: 33609017)
J Endod. 2020 Mar;46(3):352-357. (PMID: 32035640)
Int Endod J. 2015 Jun;48(6):602-10. (PMID: 25080240)
J Endod. 2005 Feb;31(2):97-100. (PMID: 15671817)
Indian J Dent Res. 2017 May-Jun;28(3):341-343. (PMID: 28722003)
J Endod. 2006 May;32(5):389-98. (PMID: 16631834)
J Endod. 2012 Jan;38(1):37-40. (PMID: 22152617)
J Transl Med. 2023 Nov 25;21(1):853. (PMID: 38007432)
Int Endod J. 2018 Mar;51(3):284-317. (PMID: 28846134)
J Endod. 2012 Oct;38(10):1330-6. (PMID: 22980172)
Int Endod J. 2022 May;55 Suppl 3:588-612. (PMID: 35338652)
Clin Oral Investig. 2013 Dec;17(9):2099-104. (PMID: 23385425)
J Formos Med Assoc. 2019 Jan;118(1 Pt 2):362-370. (PMID: 29937322)
Front Bioeng Biotechnol. 2020 Oct 29;8:580954. (PMID: 33195142)
Clin Oral Investig. 2015 Jul;19(6):1381-8. (PMID: 25467231)
J Endod. 2015 Feb;41(2):146-54. (PMID: 25301351)
J Endod. 2016 Aug;42(8):1268-72. (PMID: 27339632)
Dent Traumatol. 2025 Feb;41 Suppl 1:53-63. (PMID: 39665223)
J Clin Exp Dent. 2017 Nov 01;9(11):e1329-e1339. (PMID: 29302286)
J Endod. 2010 Mar;36(3):400-13. (PMID: 20171353)
Braz Dent J. 2013;24(4):362-6. (PMID: 24173257)
J Pharm Bioallied Sci. 2021 Jun;13(Suppl 1):S97-S100. (PMID: 34447052)
J Int Soc Prev Community Dent. 2019 Nov 13;9(6):542-552. (PMID: 32039073)
J Endod. 2016 May;42(5):730-4. (PMID: 26994597)
J Endod. 2017 Feb;43(2):238-245. (PMID: 28132710)
Clin Oral Investig. 2022 Jan;26(1):651-658. (PMID: 34213664)
Dent Mater J. 2014;33(4):453-7. (PMID: 24598240)
J Endod. 2017 Nov;43(11):1806-1820. (PMID: 28822564)
J Endod. 2009 Oct;35(10):1343-9. (PMID: 19801227)
Dent Traumatol. 2023 Apr;39(2):165-172. (PMID: 36409268)
Niger J Clin Pract. 2016 Jan-Feb;19(1):52-7. (PMID: 26755219)
Grant Information: KJ2020A0165 Natural Science Foundation of Universities of Anhui province; No.2023xkfyts04, 2022xkfyts10 Research improvement program in Stomatologic Hospital and College of Anhui Medical University; No. 2024Ab019 Anhui Provincial Health and Health Research Project
Contributed Indexing: Keywords: Apical barrier; IRoot BP plus; Open apex; Periapical lesions
Substance Nomenclature: 0 (iRoot BP Plus)
0 (Silicates)
0 (Root Canal Filling Materials)
Entry Date(s): Date Created: 20260227 Date Completed: 20260921 Latest Revision: 20261009
Update Code: 20261009
DOI: 10.1007/s00784-026-06764-4
PMID: 41760844
Βάση Δεδομένων: MEDLINE
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  – Url: https://dx.doi.org/doi:10.1007/s00784-026-06764-4
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  Data: Clinical and radiographic outcomes and associated factors of iRoot BP plus apical barrier treatment in permanent teeth with open apices and periapical lesions: a retrospective study.
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  Data: &lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Wang+J%22&quot;&gt;Wang J&lt;/searchLink&gt;; College &amp; Hospital of Stomatology, Anhui Medical University, Anhui Provincial Key Laboratory of Oral Diseases Research, 230032, Hefei, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Xiang+K%22&quot;&gt;Xiang K&lt;/searchLink&gt;; Teaching Management Office, College of Stomatology, Anhui Medical University, Hefei, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Sun+C%22&quot;&gt;Sun C&lt;/searchLink&gt;; College &amp; Hospital of Stomatology, Anhui Medical University, Anhui Provincial Key Laboratory of Oral Diseases Research, 230032, Hefei, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Ren+T%22&quot;&gt;Ren T&lt;/searchLink&gt;; College &amp; Hospital of Stomatology, Anhui Medical University, Anhui Provincial Key Laboratory of Oral Diseases Research, 230032, Hefei, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Zhang+H%22&quot;&gt;Zhang H&lt;/searchLink&gt;; College &amp; Hospital of Stomatology, Anhui Medical University, Anhui Provincial Key Laboratory of Oral Diseases Research, 230032, Hefei, China. toothyan@126.com.
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%229707115%22&quot;&gt;Clinical oral investigations&lt;/searchLink&gt; [Clin Oral Investig] 2026 Feb 28; Vol. 30 (3). &lt;i&gt;Date of Electronic Publication: &lt;/i&gt;2026 Feb 28.
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: OBJECTIVE: To evaluate clinical and radiographic outcomes of iRoot BP Plus apical barrier treatment in permanent teeth with open apices and periapical lesions and to explore associated factors. METHODS: Permanent teeth exhibiting pulp necrosis and open apices treated with iRoot BP Plus apical barrier were retrospectively included with follow-up ≥ 12 months. Treatment outcomes were determined through clinical examinations and radiographic assessments, with results classified as healed, healing, or failure. Quantitative changes in root length, root width, and apical diameter were measured on paired radiographs. Associations between baseline variables and outcomes were examined using chi-square or Fisher’s exact tests. RESULTS: A total of 54 teeth were included in the final evaluation, with a median follow-up period of 18.5 months (minimum 12 months, maximum 60 months). At final follow-up, 23 teeth (42.6%) were classified as healed, 29 (53.7%) as healing, and 2 (3.7%) as failure. Favorable outcomes (healed and healing) were observed in 52 teeth (96.3%); most teeth (52/54) were asymptomatic. Radiographs showed substantial reduction or resolution of periapical lesions. Periapical index (PAI) was significantly associated with treatment outcome (P &amp;lt; 0.05). Quantitative radiographic measurements indicated increased root length and root width with a reduction in apical diameter during follow-up. CONCLUSION: In this retrospective cohort, iRoot BP Plus apical barrier treatment showed favorable clinical and radiographic outcomes in permanent teeth with open apices and periapical lesions. CLINICAL RELEVANCE: In this study, PAI was associated with treatment outcomes, which may help clinicians in case assessment and follow-up planning.
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Declarations. Ethics approval and consent to participate: All procedures described in this manuscript have been reviewed and approved by the Ethical Committee of the Anhui Stomatological Hospital (approval: NoT2024039). Informed consent was received in writing from all participants. Competing interests: The authors declare no competing interests.
– Name: Ref
  Label: References
  Group: RefInfo
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– Name: GrantInfo
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  Data: KJ2020A0165 Natural Science Foundation of Universities of Anhui province; No.2023xkfyts04, 2022xkfyts10 Research improvement program in Stomatologic Hospital and College of Anhui Medical University; No. 2024Ab019 Anhui Provincial Health and Health Research Project
– Name: SubjectMinor
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  Data: &lt;i&gt;Keywords: &lt;/i&gt;Apical barrier; IRoot BP plus; Open apex; Periapical lesions
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  Data: 20261009
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  Data: 10.1007/s00784-026-06764-4
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s00784-026-06764-4
    Languages:
      – Code: eng
        Text: English
    Subjects:
      – SubjectFull: Dental Pulp Necrosis diagnostic imaging
        Type: general
      – SubjectFull: Dental Pulp Necrosis therapy
        Type: general
      – SubjectFull: Retrospective Studies
        Type: general
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Male
        Type: general
      – SubjectFull: Child
        Type: general
      – SubjectFull: Adolescent
        Type: general
      – SubjectFull: Young Adult
        Type: general
      – SubjectFull: Adult
        Type: general
      – SubjectFull: Middle Aged
        Type: general
      – SubjectFull: Radiography, Dental
        Type: general
      – SubjectFull: Female
        Type: general
      – SubjectFull: Silicates therapeutic use
        Type: general
      – SubjectFull: Tooth Apex diagnostic imaging
        Type: general
      – SubjectFull: Periapical Diseases diagnostic imaging
        Type: general
      – SubjectFull: Periapical Diseases therapy
        Type: general
      – SubjectFull: Apexification methods
        Type: general
      – SubjectFull: Root Canal Filling Materials therapeutic use
        Type: general
      – SubjectFull: Dentition, Permanent
        Type: general
    Titles:
      – TitleFull: Clinical and radiographic outcomes and associated factors of iRoot BP plus apical barrier treatment in permanent teeth with open apices and periapical lesions: a retrospective study.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Wang J
      – PersonEntity:
          Name:
            NameFull: Xiang K
      – PersonEntity:
          Name:
            NameFull: Sun C
      – PersonEntity:
          Name:
            NameFull: Ren T
      – PersonEntity:
          Name:
            NameFull: Zhang H
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 28
              M: 02
              Text: 2026 Feb 28
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1436-3771
          Numbering:
            – Type: volume
              Value: 30
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: Clinical oral investigations
              Type: main
ResultId 1